How transmembrane proteins sense endoplasmic reticulum stress.

abstract：:Apoptosis is a highly regulated process essential for the development and homeostasis of multicellular organisms. Whereas caspases, a large family of intracellular cysteine proteases, play central roles in the execution of apoptosis, other proapoptotic and antiapoptotic regulators such as the members of the Bcl-2 fami...

journal_title：Antioxidants & redox signaling

authors： Takeda K,Naguro I,Nishitoh H,Matsuzawa A,Ichijo H

更新日期：2011-08-01 00:00:00

abstract：:The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of the damaged base creates a baseless (AP) site. AP endonuclease1 (Ape1) acts on this site to continue the BER-pathway repa...

journal_title：Antioxidants & redox signaling

authors： Luo M,Delaplane S,Jiang A,Reed A,He Y,Fishel M,Nyland RL 2nd,Borch RF,Qiao X,Georgiadis MM,Kelley MR

更新日期：2008-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and a progressive neurodegeneration that appears to result from multiple pathogenic mechanisms (including protein misfolding/aggregation, involved in both amyloid β-dependent senile plaques and tau-dependent neurofibrillary tangles), metabolic and mitochond...

journal_title：Antioxidants & redox signaling

authors： von Bernhardi R,Eugenín J

更新日期：2012-05-01 00:00:00

abstract：:The herbicide paraquat (PQ) has been implicated as a potential risk factor for the development of Parkinson's disease. In this study, PQ (0.5-1 microM) was shown to be selectively toxic to dopaminergic (DA) neurons through the activation of microglial NADPH oxidase and the generation of superoxide. Neuron-glia culture...

journal_title：Antioxidants & redox signaling

authors： Wu XF,Block ML,Zhang W,Qin L,Wilson B,Zhang WQ,Veronesi B,Hong JS

更新日期：2005-05-01 00:00:00

abstract：SIGNIFICANCE:Dysregulation of cortical and striatal neuronal processing plays a critical role in Huntington's disease (HD), a dominantly inherited condition that includes a progressive deterioration of cognitive and motor control. Growing evidence indicates that ascorbate (AA), an antioxidant vitamin, is released into ...

journal_title：Antioxidants & redox signaling

authors： Rebec GV

更新日期：2013-12-10 00:00:00

abstract：:It has been known that glutathione S-transferases (GSTs) can reduce lipid hydroperoxides through their Se-independent glutathione peroxidase activity and that these enzymes can also detoxify lipid peroxidation end products such as 4-hydroxynonenal (4-HNE). In this article, recent studies suggesting that the Alpha clas...

journal_title：Antioxidants & redox signaling

authors： Sharma R,Yang Y,Sharma A,Awasthi S,Awasthi YC

更新日期：2004-04-01 00:00:00

abstract：: Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays a significant role in the control of redox balance, which is crucial in cancer cells. NRF2 a...

journal_title：Antioxidants & redox signaling

authors： Smolková K,Mikó E,Kovács T,Leguina-Ruzzi A,Sipos A,Bai P

更新日期：2020-11-01 00:00:00

abstract：: Significance: Hydrogen sulfide (H2S), the "new entry" in the series of endogenous gasotransmitters, plays a fundamental role in regulating the biological functions of various organs and systems. Consequently, the lack of adequate levels of H2S may represent the etiopathoge...

journal_title：Antioxidants & redox signaling

authors： Martelli A,Citi V,Testai L,Brogi S,Calderone V

更新日期：2020-01-10 00:00:00

abstract：:Liver fibrosis is the consequence of chronic liver injury of any etiology. When advanced, fibrosis causes portal hypertension and liver insufficiency, and is a risk factor for developing hepatocellular carcinoma. In the last decade, there have been major advances in the knowledge of the pathogenesis of hepatic fibrosi...

journal_title：Antioxidants & redox signaling

authors： Bataller R,Sancho-Bru P,Ginès P,Brenner DA

更新日期：2005-09-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays a crucial role in tissue pathological changes such as brain injuries. Our previous studies have demonstrated that bradykinin (BK) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and COX-2, via mitogen-activated protein kinases and nuclear fact...

journal_title：Antioxidants & redox signaling

authors： Hsieh HL,Wang HH,Wu CY,Yang CM

更新日期：2010-12-15 00:00:00

abstract：SIGNIFICANCE:Stiffness of endothelial cells is closely linked to the function of the vasculature as it regulates the release of vasoactive substances such as nitric oxide (NO) and reactive oxygen species. The outer layer of endothelial cells, consisting of the glycocalyx above and the cortical zone beneath the plasma m...

journal_title：Antioxidants & redox signaling

authors： Fels J,Kusche-Vihrog K

更新日期：2019-03-01 00:00:00

abstract：AIMS:The potential receptor for hydrogen sulfide (H2S) remains unknown. RESULTS:H2S could directly activate vascular endothelial growth factor receptor 2 (VEGFR2) and that a small interfering RNA (siRNA)-mediated knockdown of VEGFR2 inhibited H2S-induced migration of human vascular endothelial cells. H2S promoted angi...

journal_title：Antioxidants & redox signaling

authors： Tao BB,Liu SY,Zhang CC,Fu W,Cai WJ,Wang Y,Shen Q,Wang MJ,Chen Y,Zhang LJ,Zhu YZ,Zhu YC

更新日期：2013-08-10 00:00:00

abstract：: Aims: Clinical use of cisplatin (Cisp), one of the most widely used, common, and effective chemotherapeutic agents, is limited by its side effects, particularly tubular injury-associated nephrotoxicity. Previous studies suggest that hydrogen sulfide (H2S) alleviates Cisp-i...

journal_title：Antioxidants & redox signaling

authors： Yuan Y,Zhu L,Li L,Liu J,Chen Y,Cheng J,Peng T,Lu Y

更新日期：2019-12-01 00:00:00

abstract：:Although much is known about how TNF-alpha induces apoptosis in the presence of inhibitors of protein synthesis, little is known about how it induces apoptosis without these inhibitors. In this report we investigated temporal sequence of events induced by TNF-alpha in the absence of protein synthesis. Regardless of wh...

journal_title：Antioxidants & redox signaling

authors： Shakibaei M,Sung B,Sethi G,Aggarwal BB

更新日期：2010-09-15 00:00:00

abstract：AIM:To evaluate the role of matrix metalloproteinase (MMP)-9 deletion on citrate synthase (CS) activity postmyocardial infarction (MI). RESULTS:We fractionated left ventricle (LV) samples using a differential solubility-based approach. The insoluble protein fraction was analyzed by mass spectrometry, and we identified...

journal_title：Antioxidants & redox signaling

authors： de Castro Brás LE,Cates CA,DeLeon-Pennell KY,Ma Y,Iyer RP,Halade GV,Yabluchanskiy A,Fields GB,Weintraub ST,Lindsey ML

更新日期：2014-11-10 00:00:00

abstract：SIGNIFICANCE:Understanding isoform- and context-specific subcellular Nox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase compartmentalization allows relevant functional inferences. This review addresses the interplay between Nox NADPH oxidases and the endoplasmic reticulum (ER), an increasingly evid...

journal_title：Antioxidants & redox signaling

authors： Laurindo FR,Araujo TL,Abrahão TB

更新日期：2014-06-10 00:00:00

abstract：AIMS:Cigarette smoke (CS)-mediated acquired cystic fibrosis transmembrane conductance regulator (CFTR)-dysfunction, autophagy-impairment, and resulting inflammatory-oxidative/nitrosative stress leads to chronic obstructive pulmonary disease (COPD)-emphysema pathogenesis. Moreover, nitric oxide (NO) signaling regulates ...

journal_title：Antioxidants & redox signaling

authors： Bodas M,Silverberg D,Walworth K,Brucia K,Vij N

更新日期：2017-09-01 00:00:00

abstract：SIGNIFICANCE:Worldwide demand has driven the development of hemoglobin (Hb)-based oxygen carriers (HBOCs) as potential acellular oxygen therapeutics. HBOCs have the potential to provide an oxygen bridge to patients and minimize current problems associated with supply and storage of donated blood. However, to date, safe...

journal_title：Antioxidants & redox signaling

authors： Strader MB,Alayash AI

更新日期：2017-05-10 00:00:00

abstract：:Previous studies identified NADPH oxidases (Nox) and mitochondrial electron transport chain at complex I as major cellular sources of reactive oxygen species (ROS) mediating systemic and cellular responses to intermittent hypoxia (IH). In the present study, we investigated potential interactions between Nox and the mi...

journal_title：Antioxidants & redox signaling

authors： Khan SA,Nanduri J,Yuan G,Kinsman B,Kumar GK,Joseph J,Kalyanaraman B,Prabhakar NR

更新日期：2011-02-15 00:00:00

abstract：:Fluid shear stress is intimately linked with vascular oxidative stress and atherosclerosis. We posited that atherogenic oscillatory shear stress (OSS) induced mitochondrial superoxide (mtO2•-) production via NADPH oxidase and c-Jun NH(2)-terminal kinase (JNK-1 and JNK-2) signaling. In bovine aortic endothelial cells, ...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Jen N,Ai L,Hamilton R,Wang S,Holmes K,Dharbandi F,Khalsa B,Bressler S,Barr ML,Li R,Hsiai TK

更新日期：2011-09-01 00:00:00

abstract：:Efficient functioning of maintenance and repair processes seems to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, which are composed of several genes termed "vitagenes," among these, the heat shock system, a highly co...

journal_title：Antioxidants & redox signaling

authors： Calabrese V,Stella AM,Butterfield DA,Scapagnini G

更新日期：2004-10-01 00:00:00

abstract：:Dr. Gregg L. Semenza is recognized here as a Redox Pioneer because he has published three articles that have been cited more than 1,000 times, and 74 articles that have each been cited more than 100 times. Dr. Semenza is known for his seminal discovery of hypoxia-inducible factor-1 (HIF-1) and for identifying molecula...

journal_title：Antioxidants & redox signaling

authors： Prabhakar NR

更新日期：2010-08-15 00:00:00

abstract：:An increase of mitochondrial-derived reactive oxygen species (ROS) occurs in nerve growth factor (NGF)-deprived sympathetic neurons undergoing apoptotic death. It has been reported that NGF suppresses increased ROS production by the mitochondria in these cells through a mitogen-activated protein kinase kinase (MEK)/mi...

journal_title：Antioxidants & redox signaling

authors： Kirkland RA,Franklin JL

更新日期：2003-10-01 00:00:00

abstract：SIGNIFICANCE:A mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow--hypoxic vasodilation--occur in an attempt to restore oxygen supply. Nitric oxide (NO) is a major signaling...

journal_title：Antioxidants & redox signaling

authors： Umbrello M,Dyson A,Feelisch M,Singer M

更新日期：2013-11-10 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a gasotransmitter with multifaceted physiological functions, including the regulation of glucose metabolism. Methylglyoxal (MG) is an intermediate of glucose metabolism and plays an important role in the pathogenesis of insulin resistance syndromes. In the present study, we investigated the...

journal_title：Antioxidants & redox signaling

authors： Chang T,Untereiner A,Liu J,Wu L

更新日期：2010-05-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease, complications of pregnancy, cognitive impairment, and osteoporosis. That elevated homocysteine leads to vascular dysfunction may be the linking factor between these apparently unrelated pathologies. Although a growing body of evidence sugge...

journal_title：Antioxidants & redox signaling

authors： Glushchenko AV,Jacobsen DW

更新日期：2007-11-01 00:00:00

abstract：:Scholarly peer review represents the linchpin of academic publishing. Recognized benefits of the peer review system are manifold. Critics raise several valid concerns that deserve attention. Several studies show that the current peer review system lacks robustness and is subject to bias in favor of well-established re...

journal_title：Antioxidants & redox signaling

authors： Sen CK

更新日期：2012-02-15 00:00:00

abstract：:Cardiac hypertrophy and heart failure are major causes of morbidity and mortality in Western societies. Many factors have been implicated in cardiac remodeling, including alterations in gene expression in myocytes, cardiomyocytes apoptosis, cytokines and growth factors that influence cardiac dynamics, and deficits in ...

journal_title：Antioxidants & redox signaling

authors： Gupta S,Das B,Sen S

更新日期：2007-06-01 00:00:00

abstract：:Studies on thioredoxin (Trx) and its related molecules have expanded dramatically recently. Proteins that share the similar active-site sequence, -Cys-Xxx-Yyy-Cys-, are called the Trx family, and the number of Trx family members is increasing. Trx reductase, which reduces oxidized Trx in cooperation with NADPH, has th...

journal_title：Antioxidants & redox signaling

authors： Nakamura H

更新日期：2005-05-01 00:00:00

abstract：AIMS:Glutathione peroxidase (GPX) mimic ebselen and superoxide dismutase (SOD) mimic copper diisopropylsalicylate (CuDIPs) were used to rescue impaired glucose-stimulated insulin secretion (GSIS) in islets of GPX1 and(or) SOD1-knockout mice. RESULTS:Ebselen improved GSIS in islets of all four tested genotypes. The res...

journal_title：Antioxidants & redox signaling

authors： Wang X,Yun JW,Lei XG

更新日期：2014-01-10 00:00:00