Examination of cytological smears and cell blocks of pleural fluid: Complementary diagnostic value for malignant effusions.

Abstract:

OBJECTIVES:To evaluate the independent usefulness of pleural fluid smear and cell block (CB) preparations for the diagnosis of malignant effusions. PATIENTS AND METHODS:A total of 632 cytological smears and 554 CBs from 414 consecutive patients with malignant effusions were retrospectively evaluated. RESULTS:The diagnostic yield of a first specimen was 44% regardless of whether a smear or CB cytologic examination was performed. The use of subsequent separated specimens increased the identification of malignancy to 56%. Overall, 11% of samples found to be negative by cytologic smears showed malignant cells on CBs, whereas 15% of negative CBs were reported as positive on smear slides. Pleural fluid specimens with low red and/or white blood cell counts more frequently resulted in the generation of suboptimal CB preparations. CONCLUSIONS:If CBs and smears are prepared and examined, the percentage of positive diagnoses will be greater than if only one method is used.

journal_name

Rev Clin Esp

journal_title

Revista clinica espanola

authors

Porcel JM,Quirós M,Gatius S,Bielsa S

doi

10.1016/j.rce.2016.11.004

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

144-148

issue

3

eissn

0014-2565

issn

1578-1860

pii

S0014-2565(16)30191-6

journal_volume

217

pub_type

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