Galectina-3 as a biomarker of acute kidney injury risk in patients with decompensated heart failure.

Abstract:

INTRODUCTION:In decompensated heart failure (HF), both acute kidney injury (AKI) and high Galectina-3 (Gal-3) levels have been associated with poorer outcomes. Plasma Gal-3 levels are affected by renal function; however, the potential role of Gal-3 as a predictor of AKI has not been established. METHODS:We measured Gal-3 concentrations at admission for 175 patients hospitalised for HF and recorded the onset of AKI according to the Risk, Injury, Failure, Loss and End-stage kidney disease (RIFLE) analytical criteria. RESULTS:During hospitalisation, 44 patients (25.1%) developed AKI, although only 14 (8%) corresponded to more advanced stages. These 14 patients had significantly higher Gal-3 levels at admission, which remained a predictor of AKI after the multivariate adjustment by other predictors and by baseline renal function. CONCLUSIONS:High Gal-3 levels at admission are associated with a higher risk of AKI during hospitalisation for decompensated HF.

journal_name

Rev Clin Esp

journal_title

Revista clinica espanola

authors

Sanchez-Serna J,Martinez-Villanueva M,Hernández-Vicente Á,Asensio-Lopez MC,Noguera JA,Pascual-Figal DA

doi

10.1016/j.rce.2018.10.004

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

315-319

issue

6

eissn

0014-2565

issn

1578-1860

pii

S0014-2565(18)30307-2

journal_volume

219

pub_type

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