Abstract:
OBJECTIVE:Analyze the effect of AM3, an oral immunomodulator, on the exacerbations and on the use of antibiotics in patients with chronic obstructive pulmonary disease (COPD). DESIGN:Systematic search of controlled clinical trials that used AM3 in some treatment group and that included data on the clinical effects of this drug on patients with COPD. SELECTED VARIABLES: Nine studies were detected in which the clinical effectiveness of AM3 was evaluated in relation to the number of infectious exacerbations, their length, and the length of the antibiotic treatment used. RESULTS:In comparison with placebo group, the average number of excaerbations suffered by the patients treated with AM3 declined significantly in 0.31 units (p < 0.001; 95% confidence interval: 0.20-0.42), without heterogeneity among the different studies (Q = 6.62; p > 0.43). With regard to the average length of the exacerbations and the average length of the antibiotic treatment used for the exacerbations, both variables declined significantly in the group treated with AM3 (3.10 days, p < 0.001, and 8.07 days, p < 0.001, respectively) but this positive effect could not be confirmed because trials were close to heterogeneity. CONCLUSIONS:The results of this systematic review show that AM3 has a clinical effect in the prevention of exacerbations of COPD patients because reduces significantly their number. This could be related to a slowing in the progression of the deterioration in the respiratory function with a potential impact on the quality of life of the patients. Furthermore, these data imply a positive therapeutic result and a possible decline in development of bacterial resistances secondary to the frequent and indiscriminate use of antibiotics in these patients.
journal_name
Rev Clin Espjournal_title
Revista clinica espanolaauthors
Reyes Martín E,Fernández Almendros C,Alvarez-Sala JL,Alvarez-Mon Mdoi
10.1157/13065976keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
466-71issue
9eissn
0014-2565issn
1578-1860pii
13065976journal_volume
204pub_type
杂志文章abstract::Fibromyalgia or fibromyalgic syndrome (FMS) is a clinical picture of unknown origin that is characterized by generalized, incapacitating and chronic pain together with the demonstration in the physical examination of previously defined points in which moderate pressure causes pain, called fibromyalgia tender points (F...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1157/13077119
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Fractures are the clinical complication of osteoporosis. There are no previous studies that describe the prevalence of vertebral fractures (VF) in patients admitted into a hospital due to a hip fracture (HF). OBJECTIVE:To study the prevalence of vertebral fractures in elderly women in the moment of their ad...
journal_title:Revista clinica espanola
pub_type: 杂志文章,多中心研究
doi:10.1157/13109839
更新日期:2007-10-01 00:00:00
abstract::The therapeutic effect of captopril in treating mild to moderate arterial hypertension has been evaluated in 20 patients. During 15 days patients underwent a washout period. Patients then received a single dose of 50 mg of captopril by mouth per day during 4 weeks. Before and after treatment, blood pressure (BP) was c...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Liver transplant is the first therapeutic choice in most of the advanced liver diseases. Nevertheless, its performance originates a number of complications derived from: a) conservation techniques of the organ (in our study a prolonged time of hot ischemia was significantly associated with); b) surgery (all patients w...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::Antibodies (type IgG) against the A 60 antigen (Mycobacterium bovis, BCG) and an antigen of Mycobacterium tuberculosis were studied by ELISA in 79 patients with not tuberculous disease: 16 lung carcinoma, 16 hepatic cirrhosis and 47 patients with pulmonary disease. 59.5% and 50.6% of the patients showed antibodies aga...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract:INTRODUCTION:The role of glucose elevation above levels considered normal in non- diabetic patients with acute coronary syndromes (ACS) is not adequately defined. The aim of this study was to determine the association between serum glucose at admission and 1-year mortality in this type of patients. METHODS:We studied ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1157/13088586
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:To identify factors associated with poor anticoagulation control with vitaminK antagonists (VKA) among outpatients with nonvalvular atrial fibrillation (NVAF) attended in Neurology and Internal Medicine in Spain. METHODS:Cross-sectional and multicenter study, from the ALADIN database, of outpatients with NVA...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2018.04.020
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To report the clinical and epidemiologic characteristics of 19 patients diagnosed of tularemia at our hospital following an epidemic outbreak occurred in our health area. METHODS:Retrospective analysis of clinical records of patients admitted to our hospital who were examined at the Infectious Diseases Clini...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/s0014-2565(01)70854-5
更新日期:2001-07-01 00:00:00
abstract::Given the increasing interest in Lyme borreliosis in our community, and the lack of epidemiological studies in our country, we have considered convenient to analyze the presence of anti-Borrelia burgdorferi antibodies in a group of workmen who we have considered at high risk since they carry out their everyday work in...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Diabetes mellitus (DM) is characterized by a hypercoagulability state and many of these disorders are corrected with adequate metabolic control. The goal of this study was to assess diverse hemostatic and fibrinolytic parameters in 12 insulin-dependent (IDDM) metabolically controlled patients without vascular lesions ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVE:Miglitol belongs to the group of the inhibitors of the alpha-glucosidases and in several studies has demonstrated its usefulness in the improvement of the glycemic control in the different types of diabetic patients. The goal of our study was to analyze the usefulness of miglitol in the blood glucose and lipi...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1157/13056791
更新日期:2004-01-01 00:00:00
abstract::Cancer of unknown primary site (CUPS) is a heterogeneous entity defined by the presence of a histologically-proven metastatic neoplasm, in which the original tumor cannot be identified after a targeted study. The current guidelines for CUPS focus is not based on the search for the primary neoplasm but rather on the id...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/s0014-2565(09)71820-x
更新日期:2009-07-01 00:00:00
abstract::A 67-year-old woman with a history of hypertension, hyperlipidemia and 6 years of evolution of type 2 diabetes mellitus presented with fever, purulent sputum and right chest pain. She was on treatment with metformin 850 mg/bid, glimepiride 4 mg/day, candesartan 16 mg/day, atorvastatin 10mg/day and acetylsalicylic acid...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2011.05.014
更新日期:2012-02-01 00:00:00
abstract::The presence of macroamylasemia should be considered in the differential diagnosis of hyperamylasemia associated with acute abdominal pain, with suspect of pancreatitis. This uncommon and poorly known abnormality is defined as a blinding of serum amylase to certain proteins forming a circulating macrocomplex which pre...
journal_title:Revista clinica espanola
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-01 00:00:00
abstract::Although the number of elderly needing health care is increasing in Spain, geriatric patients do not receive enough attention or support when compared to that given in other countries. When the elderly get sick they present peculiar and special problems which should be attended following their needs. Because in hospit...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Central nervous system compromise is a major cause of morbidity and mortality in SLE. The clinical picture of cerebral cryptococcosis is non-specific and can be mistaken for lupic activity. A retrospective study was undertaken with 10 patients with SLE and cryptococcal meningitis compiled in a 23-year period. The most...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To determine the appearance of type 2 diabetes mellitus (DM2) and impaired fasting glucose (IFG) at five years of follow-up in a known non-diabetic population. PATIENTS AND METHODS: DESIGN:nested case control studies (case s-control into a cohort) developed in two stages: 1) identification and characterizat...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/s0014-2565(09)70351-0
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To determine which social and individual factors may predict adherence to medication in patients with more than two chronic symptomatic diseases (polypathological patients) under polypharmacy. METHODS:Cross-sectional observational study. In a primary care area assigned to our teaching hospital 265 patients ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2009.11.015
更新日期:2010-05-01 00:00:00
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journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2014.11.003
更新日期:2015-05-01 00:00:00
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journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1157/13100222
更新日期:2007-03-01 00:00:00
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journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2019.08.006
更新日期:2020-01-01 00:00:00
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journal_title:Revista clinica espanola
pub_type: 杂志文章,评审
doi:10.1016/j.rce.2019.12.013
更新日期:2020-03-17 00:00:00
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journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1157/13052582
更新日期:2003-11-01 00:00:00
abstract::Viral replication seric markers (VRSM), (BeHAg, BcHAg, and DNA-VHB) and the hepatic tissue BcHAg of thirty four patients suffering from chronic hepatopathies (6 PCH, 18 ACH, and 10 cirrhosis) were investigated. The greatest incidence of RVSM was observed in PCH. The combined study using all the markers demonstrated a ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract::In order to assess factors associated with spontaneous pneumothorax (SP), mainly climatic changes, a prospective study was undertaken of 62 SP episodes among patients admitted to our hospital during a two-year period, from January 1994 to January 1996. Atmospheric pressure (AP) changes were analyzed, with daily record...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/s0014-2565(02)70990-9
更新日期:2002-02-01 00:00:00
abstract::We present 53 cases of gastrointestinal smooth tumors (43 leiomyomas and 10 leiomyosarcomas) which have being diagnosed in Virgen del Camino Hospital during a period of 17 years. The aim of the research is to know the incidence of such tumors, their clinical presentation, the usefulness of radiologic and endoscopic st...
journal_title:Revista clinica espanola
pub_type: 杂志文章,评审
doi:
更新日期:1995-12-01 00:00:00
abstract:INTRODUCTION:This study examined the association of self-care behavior and patients' knowledge about self-care with rehospitalization among older adults with heart failure (HF). METHODS:Case-control comparison (116 cases and 209 controls) nested in a prospective cohort of patients aged 65 years and older admitted for ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1157/13123185
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:To ascertain the correlation between the partial pressure of oxygen (PaO2) and oxyhaemoglobin saturation by pulse oximetry (SpO2) in patients who were admitted to the emergency department with suspected acute respiratory failure. MATERIAL AND METHODS:A prospective, observational multicentre study was conduc...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2017.08.006
更新日期:2017-12-01 00:00:00
abstract::Since the beginning of the 20th century, there has been a progressive increase in the Earth's temperature. This warming of the Earth's surface is largely due to the so-called green house effect that can alter the natural behavior of some natural phenomena such as El Niño. Several articles on climate change have been p...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/s0014-2565(09)71240-8
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:The day hospital is an alternative to hospitalization. This alternative improves accessibility and comfort of the patients, and avoids hospitalizations. Nevertheless, the efficacy of the polyvalent medical day hospital in avoiding hospitalizations has not been evaluated. OBJECTIVE:To analyze hospital stay...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2011.08.003
更新日期:2012-02-01 00:00:00