[Study of viral replication in HbsAg positive chronic hepatitis].

Abstract:

:Viral replication seric markers (VRSM), (BeHAg, BcHAg, and DNA-VHB) and the hepatic tissue BcHAg of thirty four patients suffering from chronic hepatopathies (6 PCH, 18 ACH, and 10 cirrhosis) were investigated. The greatest incidence of RVSM was observed in PCH. The combined study using all the markers demonstrated a positive correlation: DNA-VHB and BeHAg (p less than 0,001); DNA-VHB and BcHAg (p less than 0,001); BeHAg and BcHAg (p less than 0,001). The same result was obtained when comparing BcHAg (n) with the rest of RVSM: DNA-VHB (p less than 0,001), BeHAg (p less than 0,001) and seric BcHAg (p less than 0,01). Patients with a most intense histologic activity according to the Knodell index, presented a higher ratio of positive nuclei for BcHAg. The conclusion is that there is a good correlation amongst replication markers, specially hepatic BcHAg and DNA-VHB.

journal_name

Rev Clin Esp

journal_title

Revista clinica espanola

authors

Tomás Gilabert J,Galán Navarro MI,Caballero Morales T,Maroto Vela MC,Ruiz Extremera A,Salmerón Escobar FJ

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

174-7

issue

4

eissn

0014-2565

issn

1578-1860

journal_volume

188

pub_type

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