Abstract：
:With the aim to analyze the prognostic value of anti-RNP/Sm and anti-Ro/La antibodies (Ab) in lupus nephropathy, we have studied through Contraimmunoelectrophoresis (CIE) and Immunoblotting (IB) the serum of 63 patients diagnosed of systemic lupus erythematosus. Mean age was 36.5 years (15-71) and 90% were females. We have classified the patients into three subgroups: I, 25 patients without nephropathy; II, 26 patients with evidence of nephropathy (persistent proteinuria and/or microhematuria) and normal renal function; and III, 12 patients with renal failure (servu creatinine > 1.5 mg/dl). 21 patients had kidney biopsy. IB allows to identify a higher number of positive serum, specially in the case of anti-RNP (7.9% CIE vs 28.5% IB) and anti-Sm antibodies (6.3% vs 30.1%). Prevalence of anti-RNP Ab is lower in subgroup III (32% I vs 34% II vs 8% III) (p > 0.05). Anti-Sm Ab are more frequent in group II and are not associated with renal failure (16% vs 54% vs 8%) (p > 0.05). Anti-Ro Ab are related with the absence of nephropathy (52% vs 15% vs 0%) (p < 0.05). We conclude that IB is more sensitive than CIE in the detection of these Ab and its use in Systemic Lupus Erythematosus permits to identify patient subgroups with lesser risk to develop renal failure. Even though our data are preliminary, we suggest that the detection of anti-RNP/Sm and/or anti-Ro/La antibodies are a good prognostic factor in lupus nephropathy.
journal_name
Rev Clin Espjournal_title
Revista clinica espanolaauthors
López-Longo FJ,López-Gómez JM,Jofre Ibáñez R,Escalona M,Rodríguez-Mahou Mkeywords:
subject
Has Abstractpub_date
1992-11-01 00:00:00pages
354-9issue
7eissn
0014-2565issn
1578-1860journal_volume
191pub_type
杂志文章abstract：:Hereditary hemorrhagic telangiectasia (HHT) is a hereditary dominant autosoma clinical entity characterized by repeated hemorrhages (being epistaxis the more frequent) and telangiectasia in skin, mucosa and internal organs. Incidence in Europe is 1,2 per 100,000 pop. We discuss the experience of an Internal Medicine D...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Aluminium is a toxic metal of known importance in patients with chronic renal failure on hemodialysis, with a gastrointestinal absorption modulated by several factors including gastric pH which modifies the solubility of Aluminium hydroxide and can increase its absorption. We studied twenty six patients with normal re...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：OBJECTIVES:To perform a situation analysis of the care provided by internal medicine units (IMUs) in Spain and to develop, based on this analysis, proposals for improving the quality of care in these units. MATERIAL AND METHODS:A descriptive, cross-sectional study of the IMUs of general acute care hospitals of the Spa...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2016.01.002
更新日期：2016-05-01 00:00:00
abstract：:In an open-controlled trial--oral washes (20 patients) versus test (19 patients)--, we have studied the effects of AM3 (a new oral BRM) on clinical evolution of the recurrent stomatitis (RAS) syndrome. The results obtained at 6th month showed significant decreases on ulcer numbers (p less than 0.001) as well as in the...
journal_title：Revista clinica espanola
pub_type： 临床试验,杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) encompasses a group of diseases characterized by chronic airway obstruction. This broad diagnostic umbrella includes several clinical phenotypes that overlap and respond differently to each type of therapeutic intervention. Roflumilast is a drug belonging to the new therape...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：10.1016/S0014-2565(11)70008-X
更新日期：2011-03-01 00:00:00
abstract：UNLABELLED:Wolfram's syndrome (SW): diabetes mellitus (DM), diabetes insipidus (DI), blindness and deafness, is multiorganic, hereditary and uncommon. Mitochondrial dysfunction damages the oxidative pathway. OBJECTIVE:To analyze the clinical characteristics, diagnostic delay in constituent diseases and early diagnosti...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13090481
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:AL amyloidosis is a rare condition whose management is undergoing changes due to recent advances in diagnosis and treatment. We describe a contemporary series of patients with AL amyloidosis to analyze the features that enable early diagnosis and optimal management. PATIENTS AND METHODS:We re...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2014.08.013
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To evaluate whether fast track of patients with myocardial infarction, from the emergency department to the intensive care unit, significantly decreased the intrahospital delay in the administration of anti-thrombolytic agents. PATIENTS AND METHODS:Descriptive study performed in two phases (12 and 15 months,...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Anisakis simplex is a nematode which parasitizes mainly fish and cephalopods and accidentally human beings after ingestion. Apart from the different digestive syndromes, this organism has recently been involved as cause of IgE-mediated allergic reactions of variable degree (urticaria to severe angioedema). In this rep...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:Thirty-nine percent (33/83) of patients in this study present affective disorders in the chronic phase of ischemic cerebral vascular disease (ICV). The incidence of depression reaches its maximum in atherothrombotic infarcts (52%, 15/29) and in infarcts of cardiac embolic origin (71%, 5/7), and its minimum in lacunar ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:We report here the case of a patient with fluoxetine and selegiline induced serotonin syndrome, which presented as encephalopathy, generalized myoclonias, fever, stiffness and sweating, complicated with acute renal failure, rhabdomyolysis and disseminated intravascular coagulation findings. The patient died 6 days aft...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：2002-04-01 00:00:00
abstract：UNLABELLED:The increase in the mean populational age has increased the number of elderly people eligible for cardiac surgery. The aortic pathology represents the most common valvular pathology, mainly of degenerative etiology. The efficiency of the aortic valve replacement in people aged over 75 years was studied, with...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：INTRODUCTION:The role of glucose elevation above levels considered normal in non- diabetic patients with acute coronary syndromes (ACS) is not adequately defined. The aim of this study was to determine the association between serum glucose at admission and 1-year mortality in this type of patients. METHODS:We studied ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13088586
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVE:Analyze the effect of AM3, an oral immunomodulator, on the exacerbations and on the use of antibiotics in patients with chronic obstructive pulmonary disease (COPD). DESIGN:Systematic search of controlled clinical trials that used AM3 in some treatment group and that included data on the clinical effects of ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13065976
更新日期：2004-09-01 00:00:00
abstract：:Without a doubt blood pressure autoevaluation facilitates hypertension diagnosis, control and treatment. This also helps research, makes possible costs reduction and is an easy, safe, and useful method. Its use should be favored in the new model of patient-based clinical practice. ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13072969
更新日期：2005-03-01 00:00:00
abstract：:This review proposes a more optimistic view of Alzheimer's disease (AD), in contrast to that contributed by the ageing of the population and the failure of potentially curative therapies (vaccines and others). Treatment failure is likely due to the fact that AD gestates in the brain for decades but manifests in old ag...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2016.05.010
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the exposure of children and their parents to cigarette smoke by measuring cotinine levels in saliva. PATIENTS:A total of 151 children (84 males and 67 females) aged 15 days to 17 years from hospital and extrahospital practices. METHOD:Questionnaire on exposure to cigarette smoke from their pare...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：:The clinical features of 30 patients with carcinomatous meningitis caused by solid tumors are reported. The most common originating sites of tumors were lung (12 cases) and breast (9 cases). Headache was the most common presenting symptom and there was involvement in more than one level of neuro-axis in 53% of cases. ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：OBJECTIVE:To study the evolution of antithrombin (AT) and plasma fibrinogen levels and of hematologic values among women in child-bearing age on treatment with the new hormonal oral contraceptives (HOC): in microdose, ultramicrodose and Diane-35. METHOD:Retrospective review of 100 randomized cases out of a total regis...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(01)70954-x
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVE:To know the rate of occurrence of monoclonal bands in a clinical laboratory as an estimate of monoclonal gammopathy incidence, and to detect the proportion of these bands in which an explicit clinical diagnosis or follow-up request is not established. Other objectives are to describe its distribution and the ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13075569
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:Descriptive study of severe respiratory infections caused by Pseudomonas aeruginosa in patients with HIV infection. METHODS:Review of clinical records of HIV-positive patients admitted in a tertiary hospital from 1-1-1990 to 9-30-1995. The patients included in this study were those with P. aeruginosa recover...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:The reactive hemophagocytic syndrome is a rare clinical-pathological entity which usually has a benign evolution and which is characterized by the systemic proliferation of mature histiocytes, with a great phagocytosis ability and which occurs in a secondary form in some infections and neoplasias and after the adminis...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Atrial fibrillation (AF) is the most common type of arrhythmia. The purpose of this study was to determine the prevalence of atrial fibrillation and its relationship with cardiovascular risk factors in Spain. METHODOLOGY:Cross-sectional study based on a grouped analysis of 17,291 randomized i...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2014.06.006
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Adenosine deaminase (ADA) is a key enzyme in cellular immunity. It catalyses the reaction 2'deoxyadenosine to 2'deoxiinosine, a critical step in the production of essential metabolites for the synthesis of nucleic acids. Its main physiological activity occurs in T cells of lymphoid tissue. The advanced HIV i...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:Cyclophosphamide is used both in the treatment of malignant and non-malignant diseases. Urinary neoplasms secondary to its use have been described. We discuss the case of a patient with panarteritis nodosa treated with cyclophosphamide during 63 months, with a total dose of 210 grams, and that showed a bladder neoplas...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1992-05-01 00:00:00
abstract：:Medical emergencies involving patients with Human Immunodeficiency Virus (HIV) infection comprise an increasing number of the total hospitalary consults and contribute to their overflow. In order to evaluate possible alternative solutions to this problem, we performed a retrospective study of urgent medical consults b...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Two thousand and seventy simultaneous determinations of glucose, glucosylated hemoglobin (HbA1) and plasma fructosamine have been performed in 519 diabetic patients in order to obtain a follow up index and metabolic profile. This retrospective study points out the difficulty of achieving a good metabolic control in di...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：UNLABELLED:Cystatin C (CysC) is a protease encoded by housekeeping genes. Although its prognostic value in heart failure (HF) is well known, it is debatable whether this value is due to the greater accuracy of CysC in calculating the glomerular filtration rate or to its involvement in pathological ventricular remodelli...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2015.11.003
更新日期：2016-03-01 00:00:00
abstract：:Liver transplant is the first therapeutic choice in most of the advanced liver diseases. Nevertheless, its performance originates a number of complications derived from: a) conservation techniques of the organ (in our study a prolonged time of hot ischemia was significantly associated with); b) surgery (all patients w...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Six patients with severe and complicated falciparum malaria (6.7 +/- 2.7 WHO criteria) were admitted to our Intensive Care Unit. All patients acquired the disease while travelling in tropical Africa without appropriate chemoprophylaxis. The clinical manifestations included hyperpyrexia (all patients), chills (4), swea...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
