Abstract：
BACKGROUND:Adenosine deaminase (ADA) is a key enzyme in cellular immunity. It catalyses the reaction 2'deoxyadenosine to 2'deoxiinosine, a critical step in the production of essential metabolites for the synthesis of nucleic acids. Its main physiological activity occurs in T cells of lymphoid tissue. The advanced HIV infection is characterized by a severe and progressive cellular immunity compromise. Partial positive results have been obtained with Zidovudine (AZT), a drug which Serum adenosine deaminase has been proposed as a useful marker for the assessment of the therapy response in these patients. METHODS:Serum ADA activity was determined in patients infected with HIV in stage II, before and after four months of therapy with AZT, regarding variations in its activity with improvements in biological parameters--CD4 and CD8 lymphocytes. RESULTS:Patients infected with HIV showed a significant increase in ADA activity compared with patients in the control group: 21.6 +/- 5.4 vs. 10.4 +/- 2.3 U/l (p < 0.001). Therapy with AZT decreased ADA activity: 21.6 +/- 5.4 vs. 15.2 +/- 4.3 U/l (p < 0.001) and correlated with an increase in CD4 counts: 187 +/- 105 vs. 353 +/- 145/mm3 (p < 0.001) and in CD4/CD8 ratio: 0.188 +/- 0.10 vs. 0.382 +/- 0.18 (p < 0.001). CONCLUSIONS:The detection of a decrease in ADA correlates significantly with a favourable outcome in immunological parameters in individuals infected with HIV in stage II of disease treated with AZT.
journal_name
Rev Clin Espjournal_title
Revista clinica espanolaauthors
Carrera J,Porras JA,Vidal F,Pinto B,Richart Csubject
Has Abstractpub_date
1995-02-01 00:00:00pages
74-7issue
2eissn
0014-2565issn
1578-1860journal_volume
195pub_type
杂志文章abstract：:Medical emergencies involving patients with Human Immunodeficiency Virus (HIV) infection comprise an increasing number of the total hospitalary consults and contribute to their overflow. In order to evaluate possible alternative solutions to this problem, we performed a retrospective study of urgent medical consults b...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：OBJECTIVE:Analyze the effect of AM3, an oral immunomodulator, on the exacerbations and on the use of antibiotics in patients with chronic obstructive pulmonary disease (COPD). DESIGN:Systematic search of controlled clinical trials that used AM3 in some treatment group and that included data on the clinical effects of ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13065976
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The Computerized Registry of Patients with Venous Thromboembolism (RIETE) is a prospective registry that consecutively includes patients diagnosed with venous thromboembolism. We compared the clinical presentation and response to anticoagulant treatment in patients with idiopathic venous throm...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2014.05.017
更新日期：2014-10-01 00:00:00
abstract：:The therapeutic effect of captopril in treating mild to moderate arterial hypertension has been evaluated in 20 patients. During 15 days patients underwent a washout period. Patients then received a single dose of 50 mg of captopril by mouth per day during 4 weeks. Before and after treatment, blood pressure (BP) was c...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVES:To evaluate the independent usefulness of pleural fluid smear and cell block (CB) preparations for the diagnosis of malignant effusions. PATIENTS AND METHODS:A total of 632 cytological smears and 554 CBs from 414 consecutive patients with malignant effusions were retrospectively evaluated. RESULTS:The diag...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2016.11.004
更新日期：2017-04-01 00:00:00
abstract：:The clinical records of patients attended at emergency hospitals in fifteen hospitals in Madrid, Valencia and Gran Canaria during 1994 were retrospectively analyzed. Seventy-three emergencies related to the consumption of design drugs, hallucinogens or amphetamines (100 times lower than because of opiates or cocaine) ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：UNLABELLED:An inappropriate hospital use, defined as hospital utilization that could have been occurred at a lower attending level or in less time, increases costs, creates inefficient management and influences on attending quality. The objective of this work was to evaluate the appropriateness and inappropriateness of...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:Gestational diabetes is defined as glucose intolerance of variable severity with onset or first recognition during pregnancy. Gestational Diabetes generally disappears as soon as the pregnancy is terminated. The prevalence of gestational diabetes is 2% to 13%, depending on the genetic characteristics and environment o...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1993-06-01 00:00:00
abstract：:We report the clinical, radiological and microbiological features of ten patients diagnosed of pyogenic sacroiliitis in an Internal Medicine Department during a 13 years period. Clinical signs and radiological or scintigraphical findings were present in every case. Staphylococcus aureus was isolated in blood cultures ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Patients admitted in an ICU after OH-CRA before and after the implementation of a MMICU were evaluated. During a period of 11 years, divided into a pre-MMICU period (1988-1993) and a post-MMICU period (1994-1998), 39 patients were admitted in the pre period and 64 patients in the post period. The basal characteristics...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13052582
更新日期：2003-11-01 00:00:00
abstract：:In order to know the epidemiological, clinical and evolutive characteristics of bacteriemia caused by beta-hemolytic streptococci groups A and B, a retrospective investigation was undertaken of 48 bacteremic episodes observed in adult patients for 10 years (1985-1994). Twenty-two episodes were caused by Group A beta-h...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:Basing heart failure (HF) classification on the echocardiographic values of left ventricular ejection fraction (LVEF) has been useful in defining two sub-types of HF: HF with reduced LVEF and HF with preserved LVEF. A new category has recently been defined: HF with midrange LVEF (40-49%). When current information is t...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2017.01.013
更新日期：2017-01-01 00:00:00
abstract：:Fourteen cases are revised of bronchiolalveolar carcinoma (BAC) diagnosed in our institution from 1980 to 1992. The time interval from clinical manifestations to diagnosis was 5.13 +/- 6.01 months. The incidence of smokers in the population was 42.8%. Clinical findings were non-specific, except in three cases, consist...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：OBJECTIVES:Elderly patients with acute myocardial infarction constitute a population that is not adequately represented in clinical trials or medical registries. Our objective was to compare the clinical characteristics, treatments administered and mortality among patients younger and older than 75 years. MATERIAL AND...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2014.11.003
更新日期：2015-05-01 00:00:00
abstract：:A clinical epidemiological study of reported leptospirosis cases in adults in the period 1984-1988 in the province Ciego de Avila, Republic of Cuba, was conducted. The most frequent symptoms and signs were: fever, headache and arthralgia. Eighty-two percent of patient were anicteric. The most frequent presumptive diag...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:The use of ambulatory monitorization of blood pressure has shown the importance of the alarm reaction or white coat reaction and its conditioning factors in some patients. The influence of place (medical facility or home) and person who performs the procedure (doctor or nurse) on the taking of blood pressure is studie...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Cutaneous larva migrans (CLM) is a frequent dermal disease in travelers, caused by larvae of nonhuman ancylostoma. We describe 34 outside cases of CLM diagnosed since January 1991 to June 2002. Nineteen male and female. Age: 35.7 years (20-60). The total number of CLM infestations was 73, 83.5% in feet. In five cases ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(04)71567-2
更新日期：2004-12-01 00:00:00
abstract：:We present 53 cases of gastrointestinal smooth tumors (43 leiomyomas and 10 leiomyosarcomas) which have being diagnosed in Virgen del Camino Hospital during a period of 17 years. The aim of the research is to know the incidence of such tumors, their clinical presentation, the usefulness of radiologic and endoscopic st...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1995-12-01 00:00:00
abstract：:We have screened a population of newborn babies without any previous apparent pathology in order to discover the distribution of alpha 1-anti-trypsin phenotypes (AAT) in our community. The research has been done on 457 babies born in the province of Valladolid, determining the plasma levels of AAT and the correspondin...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:Clostridium difficile is the leading cause of infectious nosocomial diarrhea in the elderly. It may cause colitis of variable severity and extraintestinal involvement. Hand transmission is the most important, and it is related to prolonged antibiotic therapies in elderly patients with severe baseline disease. Diagnosi...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13100203
更新日期：2007-02-01 00:00:00
abstract：:Malign small cell tumors in the thoracopulmonary region is a tumor of neuroectodermic origins with polymorphous and infrequent presentation. It is mostly found among young people, developing an aggressive and severe course. It is a small cell tumor involving small quantities of cytoplasm without glucogen, round or ova...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:The reactive hemophagocytic syndrome is a rare clinical-pathological entity which usually has a benign evolution and which is characterized by the systemic proliferation of mature histiocytes, with a great phagocytosis ability and which occurs in a secondary form in some infections and neoplasias and after the adminis...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：:Anisakis simplex is a nematode which parasitizes mainly fish and cephalopods and accidentally human beings after ingestion. Apart from the different digestive syndromes, this organism has recently been involved as cause of IgE-mediated allergic reactions of variable degree (urticaria to severe angioedema). In this rep...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:Metabolic syndrome is a disorder having high prevalence in our society. It is characterized by different proatherogenic disorders (dyslipidemia, arterial hypertension, hydrocarbonated intolerance, prothrombotic and proinflammatory conditions) and predisposing factors (central obesity, sedentary life and genetic factor...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13085362
更新日期：2006-02-01 00:00:00
abstract：:A retrospective study is discussed, in which the disorder of pancreatic enzymes in hospitalized patients because of an acute infectious gastroenteritis is analyzed. Of 30 cases, 15 showed a raise in lipase levels, being over 1,000 IU in five of them. There was no associated raise in amylase levels. Patients with high ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Coeliac disease is the most frequent malabsortive syndrome in daily practice. However, its true prevalence is not exactly known. The symptoms vary from patient to patient, ranging from the classic presentation with diarrhea, weight loss and fatigue to oligosymptomatic forms, being the latter more common in adults. We ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Six patients with severe and complicated falciparum malaria (6.7 +/- 2.7 WHO criteria) were admitted to our Intensive Care Unit. All patients acquired the disease while travelling in tropical Africa without appropriate chemoprophylaxis. The clinical manifestations included hyperpyrexia (all patients), chills (4), swea...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：:We have been interested in demonstrating the usefulness of the reverse endoscopic cholangiopancreatography, a technique already accepted in extrahepatic biliary pathology and the cholangiocarcinoma diagnosis. First of all we reviewed those cases diagnosed as cholangiocarcinoma using the REC and we found that only in 1...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1990-05-01 00:00:00
abstract：:The clinical features of seven patients with persistent hiccup are reported. Hiccup did not respond to the usual therapies and resolved with baclofen. The administration guidelines and secondary effects are discussed. The authors suggest baclofen should be considered the drug of choice for treating persistent hiccup. ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:Gaucher's disease is a rare condition caused by a deficiency in the lysosomal enzyme called beta-glucocerebrosidase (GBA). The objective of our work was to analyse the clinical, diagnostic and therapeutic characteristics in a group of four patients with Gaucher's disease type 1. The advantages of the new diagnostic an...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
