Abstract：
:Gaucher's disease is a rare condition caused by a deficiency in the lysosomal enzyme called beta-glucocerebrosidase (GBA). The objective of our work was to analyse the clinical, diagnostic and therapeutic characteristics in a group of four patients with Gaucher's disease type 1. The advantages of the new diagnostic and therapeutic techniques are stressed. In all cases the diagnosis was made by means of cyto-histological examination and enzymatic measurement of the beta-glucocerebrosidase activity. A genetic study and genotype determination was made in the four cases. A questionnaire was administered to patients to evaluate their life quality applying the SF36 questionnaire adapted to the Gaucher's disease. All subjects have received enzymatic replacement therapy with the recombinant enzyme imiglucerase (Cerezyme Corporation) with a satisfactory clinical course. Interestingly, eosinophilia was present in one patient, which disappeared after treatment.
journal_name
Rev Clin Espjournal_title
Revista clinica espanolaauthors
Adarraga Cansino MD,Fernández de la Puebla R,Jiménez Perepérez JA,Pocoví Mieras M,Zambrana García JL,Pérez Jiménez Fkeywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
635-7issue
12eissn
0014-2565issn
1578-1860pii
13040512journal_volume
202pub_type
杂志文章abstract：:Antibodies (type IgG) against the A 60 antigen (Mycobacterium bovis, BCG) and an antigen of Mycobacterium tuberculosis were studied by ELISA in 79 patients with not tuberculous disease: 16 lung carcinoma, 16 hepatic cirrhosis and 47 patients with pulmonary disease. 59.5% and 50.6% of the patients showed antibodies aga...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND:There are no simple and validated instruments for evaluating the training of specialists. OBJECTIVES:To analyze the reliability and validity of a computerized self-assessment method to quantify the acquisition of medical competences during the Internal Medicine residency program. METHODS:All residents of o...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2012.04.004
更新日期：2012-12-01 00:00:00
abstract：:Study of the human proteome has given rise to the appearance of abundant and increasing scientific literature. This has resulted in the proposal to use proteomic techniques in the management of some diseases and the suggestion of its future use in clinical laboratories. In order to identify which proteomic techniques ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13107947
更新日期：2007-07-01 00:00:00
abstract：:In most cases, the etiological diagnosis of pleural exudates does not require a pleural biopsy. However, when it is considered necessary, the biopsy should seldom be conducted using invasive methods such as thoracoscopy. Two paradigmatic examples are pleural tuberculosis and malignant effusions. In many centres, pleur...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2017.02.016
更新日期：2017-10-01 00:00:00
abstract：:The name fetus-in-fetu designates the presence of a tumoral mass containing a homunculus. Fewer than 70 cases have been reported in the literature since its first description about 1800. This entity usually presents in childhood and it is exceptional in adult life. There is an interesting debate regarding its origin a...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1996-11-01 00:00:00
abstract：:In pneumonias, the short diagnostic results of non-invasive procedures lead frequently to use invasive techniques, among which we find pulmonary puncture aspiration (PPA). In this study, the profitability of PPA in the diagnosis of pneumonias is evaluated. One hundred and thirteen PPA were performed on 107 patients di...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:We have studied a group of 33 (27 female and 6 male) patients suffering pure essential arterial hypertension, with a mean age of 54.06 years, and who received a daily monodose of chlortalidone. Arterial pressure, blood viscosity at different shearing levels, as well as those parameters capable of modifying this viscos...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：OBJECTIVE:To analyze the different therapeutic attitudes towards patients with arterial hypertension (AH) or white coat hypertension (WCH). DESIGN:Longitudinal, retrospective study after performing a 24 h ambulatory blood pressure monitoring of ABPM. SETTING:Urban health center. PATIENTS:Eighty-six patients aged ove...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:This study tries to know the opinion of pharmaceutical detailers about their profession, as well as their pharmacological knowledge. 75 questionnaires were distributed to an equal number of detailers. The questionnaires were composed of two parts. In the first one, several questions about their profession were posed. ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
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journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：OBJECTIVE:Analyze whether the tablets available in Spain are useful for oral replacement in the treatment of vitamin B12 deficiency. METHODS:From June 2003 to December 2005, patients with vitamin B12 deficiency attended at the Internal Medicine Clinic, were offered the possibility of starting or switching to oral ther...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13101846
更新日期：2007-04-01 00:00:00
abstract：:Pneumonia due to Pneumocystis carinii (PC) is characterized, in most cases, by the existence of infiltrates of interstitium or bilateral interstitium-alveolar type on the thorax radiography. However atypical radiological findings associated with this type of opportunistic infection are being described more and more fr...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:The purpose of this study is to determine the characteristics of spirometric performance in a group of smokers and to carry out a prospective study of the changes in ventilatory lung function after smoking withdrawal. The ventilatory lung function was studied in 90 smokers and 30 non-smokers. Afterwards the smokers we...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Fourteen cases are revised of bronchiolalveolar carcinoma (BAC) diagnosed in our institution from 1980 to 1992. The time interval from clinical manifestations to diagnosis was 5.13 +/- 6.01 months. The incidence of smokers in the population was 42.8%. Clinical findings were non-specific, except in three cases, consist...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:The cerebral trunk infection by Listeria monocytogenes is a very rare process, with only 24 described cases and only 2 in immunodepressed patients. We present a new case of cerebral trunk encephalitis caused by Listeria in a patient diagnosed of Polyarteritis nodosa on steroids and cyclophosamide treatment and fatal e...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:In the present work we study the modifications in hydrosaline metabolism which occurred in two groups of healthy male individuals, one consisting of 15 young men (mean age of 20 years) and the other of 30 elderly subjects (mean age of 75 years) when the thirst test was performed for 48 hours. After performing the thir...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:We here present the case of a patient who starts with a progressive vision loss, observing in the radiologic exam herniation of optic chiasma in a primary empty sella turcica. Based on this case, we have performed a review of this clinical picture and point out the most important aspects in the literature. ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：OBJECTIVES:To describe the complications and the diagnostic yield of percutaneous liver biopsies performed under ultrasonographic control in an Internal Medicine department. PATIENTS AND METHODS:A total of 750 percutaneous liver biopsies were performed at the Internal Medicine department of our institution during the ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(03)71251-x
更新日期：2003-05-01 00:00:00
abstract：:Aluminium is a toxic metal of known importance in patients with chronic renal failure on hemodialysis, with a gastrointestinal absorption modulated by several factors including gastric pH which modifies the solubility of Aluminium hydroxide and can increase its absorption. We studied twenty six patients with normal re...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:Patients admitted in an ICU after OH-CRA before and after the implementation of a MMICU were evaluated. During a period of 11 years, divided into a pre-MMICU period (1988-1993) and a post-MMICU period (1994-1998), 39 patients were admitted in the pre period and 64 patients in the post period. The basal characteristics...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13052582
更新日期：2003-11-01 00:00:00
abstract：:Despite its high frequency, there is not a consensus for the management of a patient with mild head trauma. In this prospective study we analyzed wether the transient loss of consciousness was associated with a higher risk of cranioencephalic injury in function of patient's age. Fifty-two patients with a Glasgow score...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:The socio-economic cost of human brucellosis is analyzed. One hundred and seven patients are included in this study, 75 males (70.09%) and 32 females (29.91), diagnosed of brucellosis in the Internal Medicine Department of the Regional Hospital "Carlos Haya" in Málaga from the 1st of October 1984 to the 31st of Decemb...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：OBJECTIVES:To perform a situation analysis of the care provided by internal medicine units (IMUs) in Spain and to develop, based on this analysis, proposals for improving the quality of care in these units. MATERIAL AND METHODS:A descriptive, cross-sectional study of the IMUs of general acute care hospitals of the Spa...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2016.01.002
更新日期：2016-05-01 00:00:00
abstract：:A case report of severe digitalis poisoning in a patient with prosthetic heart valve is presented. He complained of nausea, vomiting, drowsiness, temporal disorientation and lethargy. The electrocardiogram showed idioventricular rhythm, and plasma levels of digoxin were 6.78 ng/ml. Predisposing factors por digitalis p...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:Painful legs and moving toes syndrome is a rare medical picture characterized by involuntary movements of the toes or the whole foot and pain in lower limbs. However, this must be kept in mind due to its association with other diseases and its possibility of being the first symptom. Spinal cord and cauda equina diseas...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：10.1157/13102318
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Oral anticoagulant therapy is complex due to the need for control and the hemorrhagic risk the therapy entails. This study aims to determine the standard clinical practice in the treatment for preventing stroke in patients with nonvalvular atrial fibrillation (NVAF) in Spain. PATIENTS AND MET...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2014.08.008
更新日期：2015-03-01 00:00:00
abstract：:Cutaneous larva migrans (CLM) is a frequent dermal disease in travelers, caused by larvae of nonhuman ancylostoma. We describe 34 outside cases of CLM diagnosed since January 1991 to June 2002. Nineteen male and female. Age: 35.7 years (20-60). The total number of CLM infestations was 73, 83.5% in feet. In five cases ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(04)71567-2
更新日期：2004-12-01 00:00:00
abstract：UNLABELLED:An inappropriate hospital use, defined as hospital utilization that could have been occurred at a lower attending level or in less time, increases costs, creates inefficient management and influences on attending quality. The objective of this work was to evaluate the appropriateness and inappropriateness of...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:Deep vein thrombosis (DVT) is part of the clinical spectrum of venous thromboembolism disease (VTE), whose estimated annual incidence rate is 1-2 episodes per 1000 individuals and represents the third leading cause of cardiovascular mortality in developed countries. Establishing an accurate diagnosis of DVT is essenti...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：10.1016/j.rce.2020.03.009
更新日期：2020-06-27 00:00:00
abstract：UNLABELLED:The objective of surgical treatment in ulcerative colitis (UC) and Crohn's disease (CD) differs. Surgery in UC is more aggressive and potentially curative whereas in CD it is more conservative and palliative. OBJECTIVE:To assess the opinion of patients with inflammatory bowel disease who underwent surgery i...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(00)70698-9
更新日期：2000-09-01 00:00:00
