Abstract：
OBJECTIVE:Analyze whether the tablets available in Spain are useful for oral replacement in the treatment of vitamin B12 deficiency. METHODS:From June 2003 to December 2005, patients with vitamin B12 deficiency attended at the Internal Medicine Clinic, were offered the possibility of starting or switching to oral therapy. Clinical and biochemical responses were monitored at baseline and at 2, 4, 6, 12, 18 y 24 months of follow-up. RESULTS:Twenty-eight patients were included (55.6% women), with a mean age of 74.96 +/- 9.98 years. Twenty-three cases (82.1%) had pernicious anemia, and 5 were gastrectomized. Patients who switched from intramuscular to oral therapy (16 cases) showed no decrease in the mean values of hemoglobin and B12 levels during the follow-up. Patients who started on oral therapy showed an increase in the values of hemoglobin (from 9.9 +/- 2.8 g/dl to 13.5 +/- 1.1, p = 0.003) and vitamin B12 (from 118 +/- 50 pg/ml to 496 +/- 229, p = 0.001) as early as two months after baseline, maintaining the response during the follow-up. No patient refused oral therapy and no toxic effect attributed to oral therapy was recorded. CONCLUSIONS:Oral replacement of vitamin B12 deficiency with the tablets available in Spain is safe, effective and acceptable to patients.
journal_name
Rev Clin Espjournal_title
Revista clinica espanolaauthors
Rabuñal Rey R,Monte Secades R,Peña Zemsch M,Bal Alvaredo M,Gómez Gigirey Adoi
10.1157/13101846subject
Has Abstractpub_date
2007-04-01 00:00:00pages
179-82issue
4eissn
0014-2565issn
1578-1860pii
13101846journal_volume
207pub_type
杂志文章abstract：OBJECTIVE:To study the evolution of antithrombin (AT) and plasma fibrinogen levels and of hematologic values among women in child-bearing age on treatment with the new hormonal oral contraceptives (HOC): in microdose, ultramicrodose and Diane-35. METHOD:Retrospective review of 100 randomized cases out of a total regis...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(01)70954-x
更新日期：2001-12-01 00:00:00
abstract：:The proportion of diabetic patients who are hospitalised for stroke has been increasing in recent years, currently reaching almost a third of all cases of stroke. In addition, about half of patients with acute stroke present hyperglycaemia in the first hours of the stroke. Although hyperglycaemia in the acute phase of...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2015.06.005
更新日期：2016-03-01 00:00:00
abstract：UNLABELLED:The objective of surgical treatment in ulcerative colitis (UC) and Crohn's disease (CD) differs. Surgery in UC is more aggressive and potentially curative whereas in CD it is more conservative and palliative. OBJECTIVE:To assess the opinion of patients with inflammatory bowel disease who underwent surgery i...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(00)70698-9
更新日期：2000-09-01 00:00:00
abstract：:Thirty-eight hepatitis B virus (HBV) carriers, AgHBs and anti-HBe positive, with histologic diagnosis of chronic hepatitis have been periodically revised for three years. Three of them were homosexuals. Fourteen patients presented reactivation of viral replication characterized by the appearance in serum of HBV-DNA an...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:High concentrations of total and LDL-cholesterol and low concentrations of HDL-cholesterol are related to morbidity and mortality due to cardiovascular diseases. In this study, lipid concentration, prevalence of hypercholesterolemia and the association between hypercholesterolemia and other cardiovascular ri...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:To determine which factors are associated with a functional gain above 19 on Barthel's index (CSFG) and also factors associated with a new post-discharge institutionalisation (NPDI) in patients who a underwent rehabilitation intervention whilst admitted to a medium long term care unit. PATIEN...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2009.06.004
更新日期：2010-01-01 00:00:00
abstract：:215 cases diagnosed of human leptospirosis in the Camagüey Province, Cuba, are studied, for the period between 1986 and 1990. The clinical and epidemiological features are studied, together with the anatomopathological study of the decreased. The most frequent complications and the treatment employed, including prophy...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:Cystic neoplasms of the pancreas make up a group of uncommon tumors. Their relevance lies upon their favorable prognosis after resection and the fact of being commonly mistaken with pseudocysts. Based on five patients treated at our hospital in the last few years we make an update review of the literature on these tum...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-01 00:00:00
abstract：:Gaucher's disease is a rare condition caused by a deficiency in the lysosomal enzyme called beta-glucocerebrosidase (GBA). The objective of our work was to analyse the clinical, diagnostic and therapeutic characteristics in a group of four patients with Gaucher's disease type 1. The advantages of the new diagnostic an...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:The use of ambulatory monitorization of blood pressure has shown the importance of the alarm reaction or white coat reaction and its conditioning factors in some patients. The influence of place (medical facility or home) and person who performs the procedure (doctor or nurse) on the taking of blood pressure is studie...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Sarcoidosis is a disease which presents important clinical differences according to its geographical distribution. Thus, the objective of this study was to evaluate the epidemiologic, clinical, radiologic, and diagnostic characteristics in a series of 30 sarcoidosis patients in the province of Salamanca (representing ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：:In this clinical observation, we make a small summary of the current state of pharmacological treatment of obesity. The interest in the use of drugs in the treatment of obesity has grown in recent years, upon our knowledge of the biological basis of obesity having increased, and also because non-pharmacological treatm...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13074165
更新日期：2005-04-01 00:00:00
abstract：:For patients to be able to make decisions autonomously (and to grant informed consent), they must have information, understanding, freedom and willingness, with competence a prerequisite for autonomy. Clinicians are often faced with patients lacking competence to make decisions but detect less than half of such cases ...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：10.1016/j.rce.2019.04.009
更新日期：2020-05-01 00:00:00
abstract：:The clinical histories of all the patients with hemoptysis who underwent bronchofibroscopy (FB) during a period of 5 years (1981-1986) are revised. 25.6% (108 out of 702) of the endoscopic explorations were performed in patients without radiographic pleuropulmonary abnormalities with a definite pathology. In these pat...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:Usually, there is a physiological fall in nocturnal blood pressure among all individuals, both hypertensive and normotensive individuals. The lack of nocturnal blood pressure (BP) fall may be associated with the risk of developing cardiovascular complications in hypertensive patients. Cardiovascular and horm...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(02)71048-5
更新日期：2002-05-01 00:00:00
abstract：:Patients admitted in an ICU after OH-CRA before and after the implementation of a MMICU were evaluated. During a period of 11 years, divided into a pre-MMICU period (1988-1993) and a post-MMICU period (1994-1998), 39 patients were admitted in the pre period and 64 patients in the post period. The basal characteristics...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13052582
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Clinical management for terminal patients should consider various aspects, particularly the patient's functional assessment, which correlates well with the short-term prognosis. The prognosis could improve if the presence of symptoms strongly associated with a poorer progression were included....
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2019.01.003
更新日期：2019-01-01 00:00:00
abstract：:Central nervous system compromise is a major cause of morbidity and mortality in SLE. The clinical picture of cerebral cryptococcosis is non-specific and can be mistaken for lupic activity. A retrospective study was undertaken with 10 patients with SLE and cryptococcal meningitis compiled in a 23-year period. The most...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Hereditary hemorrhagic telangiectasia (HHT) is a hereditary dominant autosoma clinical entity characterized by repeated hemorrhages (being epistaxis the more frequent) and telangiectasia in skin, mucosa and internal organs. Incidence in Europe is 1,2 per 100,000 pop. We discuss the experience of an Internal Medicine D...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Fourteen cases are revised of bronchiolalveolar carcinoma (BAC) diagnosed in our institution from 1980 to 1992. The time interval from clinical manifestations to diagnosis was 5.13 +/- 6.01 months. The incidence of smokers in the population was 42.8%. Clinical findings were non-specific, except in three cases, consist...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:A patient who had been successfully treated of Hodgkin's disease (nodular sclerotic type) with mediastinal radiotherapy and polychemotherapy, suffered an acute pericarditis immediately after radiotherapy and a complete atrial-ventricular block 14 years later. Five years later she presented refractory hemorrhagic perit...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Coeliac disease is the most frequent malabsortive syndrome in daily practice. However, its true prevalence is not exactly known. The symptoms vary from patient to patient, ranging from the classic presentation with diarrhea, weight loss and fatigue to oligosymptomatic forms, being the latter more common in adults. We ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVES:Heart failure decompensation is the most common reason for hospitalization in persons over 65 years old. There is limited information on the prevalence of precipitating factors of heart failure decompensation in this population. In this study we prospectively examined the factors associated with decompensati...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2010.04.020
更新日期：2010-11-01 00:00:00
abstract：:The clinical features of 30 patients with carcinomatous meningitis caused by solid tumors are reported. The most common originating sites of tumors were lung (12 cases) and breast (9 cases). Headache was the most common presenting symptom and there was involvement in more than one level of neuro-axis in 53% of cases. ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:Amongst 1.202 genital samples studied, the microscopic exam revealed in 179 (14.8%) cases flora compatible with bacterial vaginitis. Of these 179 samples, Mobiluncus SP was observed in 35 (19.6%) using Gram staining and in 18 (10.1%) this microorganism was isolated in agar RLK and anaerobic atmosphere. Using biochemic...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:Pneumonia due to Pneumocystis carinii (PC) is characterized, in most cases, by the existence of infiltrates of interstitium or bilateral interstitium-alveolar type on the thorax radiography. However atypical radiological findings associated with this type of opportunistic infection are being described more and more fr...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to determine the prognostic factors in relationship to evolution to death of bacteremia-fungemia (BF) episodes occurred in 1986 and to compare them with the results obtained ten years later in 1996. PATIENTS AND METHODS:Prospective study of all BF episodes observed at Hospital...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(01)70765-5
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:There are no simple and validated instruments for evaluating the training of specialists. OBJECTIVES:To analyze the reliability and validity of a computerized self-assessment method to quantify the acquisition of medical competences during the Internal Medicine residency program. METHODS:All residents of o...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2012.04.004
更新日期：2012-12-01 00:00:00
abstract：:A case of diffuse mediastinal lipomatosis (ML) is described, associated to exogenous obesity, infrequent entity, which is comprehended within the causes which can cause mediastinal broadening. The clinical characteristics of our observation and the general aspects of interest are reviewed for this type of mediastinal ...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1993-04-01 00:00:00
abstract：:The socio-economic cost of human brucellosis is analyzed. One hundred and seven patients are included in this study, 75 males (70.09%) and 32 females (29.91), diagnosed of brucellosis in the Internal Medicine Department of the Regional Hospital "Carlos Haya" in Málaga from the 1st of October 1984 to the 31st of Decemb...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
