[Evolution of antithrombin activity and plasma fibrinogen levels and of hematologic values among women in child-bearing age on treatment with the new hormonal oral contraceptives].

Abstract:

OBJECTIVE:To study the evolution of antithrombin (AT) and plasma fibrinogen levels and of hematologic values among women in child-bearing age on treatment with the new hormonal oral contraceptives (HOC): in microdose, ultramicrodose and Diane-35. METHOD:Retrospective review of 100 randomized cases out of a total registry of 1,245 clinical records. RESULTS:The mean age in our series was 23.4 years (range: 18-39 years). The mean study time was 3.3 years (range: 1-5 years). During the study period, there was not a single woman with an AT lower than 70%. There were no significant changes at the end of the study period regarding AT, plasma fibrinogen, hematocrit, hemoglobin, prothrombin activity and activated partial thromboplastin time. A significant decrease was observed for platelet count (246,113 5,842 vs. 215,636 4,383 platelets/mm3; p = 0.003). There was not a single case of thrombocytopenia registered. No relevant differences were observed between the treatment groups with microdosaged, ultramicrodosaged and Diane-35. CONCLUSIONS:At mid-term (3.3 years), the new HOC (in microdose, ultramicrodose and Diane-35), do not cause significant changes in AT, plasma fibrinogen, hematocrit, hemoglobin, prothrombin activity and activated partial thromboplastin time. In our series, a moderate but significant decrease in the platelet count was observed but there were no cases of thrombocytopenia. The effect of the different new HOC on the studied parameters was similar.

journal_name

Rev Clin Esp

journal_title

Revista clinica espanola

authors

Calvo Romero JM,Lima Rodríguez EM,Peinado Rodríguez MT,Bureo Dacal P,Pérez Miranda M

doi

10.1016/s0014-2565(01)70954-x

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

701-3

issue

12

eissn

0014-2565

issn

1578-1860

pii

13025168

journal_volume

201

pub_type

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