Abstract：
:Chronic obstructive pulmonary disease (COPD) encompasses a group of diseases characterized by chronic airway obstruction. This broad diagnostic umbrella includes several clinical phenotypes that overlap and respond differently to each type of therapeutic intervention. Roflumilast is a drug belonging to the new therapeutic class of phosphyldiesterase-4 (PDE4) inhibitors and can be considered the first drug to be developed for a specific COPD phenotype (COPD associated with chronic bronchitis). In preclinical models, roflumilast has shown potent antiinflammatory action against a wide variety of cells and inflammatory mediators, as well as against the etiopathogenic mechanisms of COPD. The present article reviews the evidence generated during the clinical development of roflumilast, with special emphasis on studies evaluating the drug in a context similar to that of routine clinical practice.
journal_name
Rev Clin Espjournal_title
Revista clinica espanolaauthors
Izquierdo Alonso JLdoi
10.1016/S0014-2565(11)70008-Xsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
22-30eissn
0014-2565issn
1578-1860pii
S0014-2565(11)70008-Xjournal_volume
211 Suppl 2pub_type
杂志文章,评审abstract：BACKGROUND:Description of the patients admitted in the general Internal Medicine (IM) departments of the Public Health System in Andalusia (Spain) (PHSA) during 2002. PATIENTS AND METHODS:It is an analysis of the Minimum Basic Set of Data (MBSD) and its management by the Diagnostic Related Groups (DRG) of admission ep...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13084760
更新日期：2006-01-01 00:00:00
abstract：:For patients to be able to make decisions autonomously (and to grant informed consent), they must have information, understanding, freedom and willingness, with competence a prerequisite for autonomy. Clinicians are often faced with patients lacking competence to make decisions but detect less than half of such cases ...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：10.1016/j.rce.2019.04.009
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVES:Elderly patients with acute myocardial infarction constitute a population that is not adequately represented in clinical trials or medical registries. Our objective was to compare the clinical characteristics, treatments administered and mortality among patients younger and older than 75 years. MATERIAL AND...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2014.11.003
更新日期：2015-05-01 00:00:00
abstract：:The presence of anti-HIV (human immunodeficiency virus) antibodies was determined in 325 subjects. The samples were taken from 138 convicts from Carabanchel and Ocaña I jail, 162 parenteral drug addicts (PDA) from a center for rehabilitation of drug addicts (CR), and from 14 family members and 11 stable couples of the...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：OBJECTIVES:To determine which social and individual factors may predict adherence to medication in patients with more than two chronic symptomatic diseases (polypathological patients) under polypharmacy. METHODS:Cross-sectional observational study. In a primary care area assigned to our teaching hospital 265 patients ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2009.11.015
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVES:To evaluate the independent usefulness of pleural fluid smear and cell block (CB) preparations for the diagnosis of malignant effusions. PATIENTS AND METHODS:A total of 632 cytological smears and 554 CBs from 414 consecutive patients with malignant effusions were retrospectively evaluated. RESULTS:The diag...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2016.11.004
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:High concentrations of total and LDL-cholesterol and low concentrations of HDL-cholesterol are related to morbidity and mortality due to cardiovascular diseases. In this study, lipid concentration, prevalence of hypercholesterolemia and the association between hypercholesterolemia and other cardiovascular ri...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：OBJECTIVES:To perform a situation analysis of the care provided by internal medicine units (IMUs) in Spain and to develop, based on this analysis, proposals for improving the quality of care in these units. MATERIAL AND METHODS:A descriptive, cross-sectional study of the IMUs of general acute care hospitals of the Spa...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2016.01.002
更新日期：2016-05-01 00:00:00
abstract：:A case of diffuse mediastinal lipomatosis (ML) is described, associated to exogenous obesity, infrequent entity, which is comprehended within the causes which can cause mediastinal broadening. The clinical characteristics of our observation and the general aspects of interest are reviewed for this type of mediastinal ...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1993-04-01 00:00:00
abstract：OBJECTIVES:Celiac disease is a chronic immune-mediated disease of the small intestine. It has been known that dilated cardiomyopathy and ischemic coronary artery disease have become more frequent in patients with celiac disease. The aim of the study was to assess Tp-e interval and Tp-e/QT ratio in patients with celiac ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2017.09.001
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVE:To report the clinical and epidemiologic characteristics of 19 patients diagnosed of tularemia at our hospital following an epidemic outbreak occurred in our health area. METHODS:Retrospective analysis of clinical records of patients admitted to our hospital who were examined at the Infectious Diseases Clini...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(01)70854-5
更新日期：2001-07-01 00:00:00
abstract：:The limitation of the therapeutic effort (LTE) consists in not applying extraordinary or disproportionate measures for therapeutic purposes that are proposed for a patient with poor life prognosis and/or poor quality of life. There are two types. The first is to not initiate certain measures or to withdraw them when t...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2011.04.016
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:To identify the main characteristics in patients with COPD exacerbation, capables to predict the short-term COPD mortality. MATERIALS AND METHODS:This is a case-control retrospective study of admitted patients with COPD to identify risk factors of mortality. The control group was constituted by alive patient...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2010.02.008
更新日期：2010-07-01 00:00:00
abstract：:Comparative performance of four methods (IFI, IgM anti-VCA, Organon Teknika; ELISA, IgM anti VCA, Incstar Corp and Pharmacia Diagnostic Inc; ELISA IgM against a group of several antigens which principal component is EBNA, Behring Institute) to detect antibodies (Abs) against Epstein-Barr virus in 180 patients (group 1...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Oral anticoagulant therapy is complex due to the need for control and the hemorrhagic risk the therapy entails. This study aims to determine the standard clinical practice in the treatment for preventing stroke in patients with nonvalvular atrial fibrillation (NVAF) in Spain. PATIENTS AND MET...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2014.08.008
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:To determine the bacterial etiology of bacteremic episodes recorded at our hospital during 1995 and their antimicrobial susceptibility patterns. METHODS:The microbiological records of all bacteremic episodes detected at our hospital from January to December 1995 were analysed. The susceptibility patterns of ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：INTRODUCTION:The role of glucose elevation above levels considered normal in non- diabetic patients with acute coronary syndromes (ACS) is not adequately defined. The aim of this study was to determine the association between serum glucose at admission and 1-year mortality in this type of patients. METHODS:We studied ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13088586
更新日期：2006-06-01 00:00:00
abstract：:The watermelon stomach is a vascular malformation at the gastric antrum which is responsible for chronic bleeding. We report here nine patients (5 females and 4 males) referred to our Department from December 1990 to May 1995 with ferropenic anemia resulting from chronic gastrointestinal bleeding and with the diagnosi...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:In this clinical observation, we make a small summary of the current state of pharmacological treatment of obesity. The interest in the use of drugs in the treatment of obesity has grown in recent years, upon our knowledge of the biological basis of obesity having increased, and also because non-pharmacological treatm...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1157/13074165
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:To identify overuse (diagnostic, therapeutic and self-care practices that represent risks that outweigh the potential benefits) in patients with atrial fibrillation. METHOD:The study was based on qualitative research techniques. Using the "Metaplan" technique, we identified and ordered potentially inappropri...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2017.02.014
更新日期：2017-05-01 00:00:00
abstract：:Breast cancer is the most frequent cancer in Western females. After the controversy sustained over many years in which the rentability of early diagnosis and the secondary potential effects of periodic mammographies was questioned, nowadays there is no question about their value. Performance of these campaigns for the...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:To estimate the use of resources and costs of health care to patients infected with the human immunodeficiency virus (HIV). METHODS:Prospective study in university hospital in Catalonia including 166 patients. AIDS was defined following 1987 criteria of the Centers for Disease Control. AIDS phase was divide...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:We have been interested in demonstrating the usefulness of the reverse endoscopic cholangiopancreatography, a technique already accepted in extrahepatic biliary pathology and the cholangiocarcinoma diagnosis. First of all we reviewed those cases diagnosed as cholangiocarcinoma using the REC and we found that only in 1...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：
更新日期：1990-05-01 00:00:00
abstract：:Central venous catheters are essential in modern-day medical practice, particularly in intensive care units. Although such catheters provide necessary vascular access, their use puts patients at risk of mechanical and infectious complications. Unfortunately, these complications are associated with an increase of the m...
journal_title：Revista clinica espanola
pub_type： 杂志文章,评审
doi：10.1157/13084771
更新日期：2006-01-01 00:00:00
abstract：:Pneumonia due to Pneumocystis carinii (PC) is characterized, in most cases, by the existence of infiltrates of interstitium or bilateral interstitium-alveolar type on the thorax radiography. However atypical radiological findings associated with this type of opportunistic infection are being described more and more fr...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:In order to assess the bacteriology of bronchial secretion samples, 40 patients in the intensive care unit who had developed fever and pulmonary infiltrates during mechanical ventilation have been studied. In each patient bronchial secretion samples were obtained by a double lumen distally-plugged telescopic catheter ...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：BACKGROUND:The increase in intraabdominal pressure (IAP) has been correlated with increased creatinine levels in patients with heart failure with severely reduced left ventricular ejection fraction (HFrEF). However, IAP has not been examined in more stable patients or those with heart failure with preserved ejection fr...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2020.01.011
更新日期：2020-07-09 00:00:00
abstract：:The editors of Revista Clínica Española (Rev Clin Esp) inform on their editorial activity during the last 12 months (November 2010 to October 2011): (a) Objectives and attainments during 2011, (b) editorial activity, and (c) objectives for 2012. In 2011 we have updated the editorial algorithm (revision by the responsi...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2011.11.004
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:The day hospital is an alternative to hospitalization. This alternative improves accessibility and comfort of the patients, and avoids hospitalizations. Nevertheless, the efficacy of the polyvalent medical day hospital in avoiding hospitalizations has not been evaluated. OBJECTIVE:To analyze hospital stay...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/j.rce.2011.08.003
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To know the characteristics of nocardiosis in HIV infected patients. PATIENTS AND METHODS:Retrospective analysis of HIV infected patients with a concomitant Nocardia spp. infection in nine Andalusian hospitals. RESULTS:Eighteen cases of nocardiosis were studied. Seventeen patients were males and the mean ag...
journal_title：Revista clinica espanola
pub_type： 杂志文章
doi：10.1016/s0014-2565(02)71084-9
更新日期：2002-07-01 00:00:00
