Abstract:
BACKGROUND:The immune response to Mycobacterium tuberculosis is primarily mediated by T lymphocytes. In this study an investigation was made of T lymphocytes and their subsets, B lymphocytes and natural cytotoxic cells (Natural Killer, NK) in blood and organic fluids in different tuberculosis conditions. METHODS:Patients with localized pulmonary tuberculosis (LPT, n = 12), extensive pulmonary tuberculosis (EPT, n = 24), pleural tuberculosis (PLE, n = 14), disseminated tuberculosis (DIS, n = 10), recent Mantoux converters (MAN, n = 15) and healthy subjects (CON, n = 19) were studied. HIV+ and immunosuppressed patients were excluded. Total lymphocytes and T subsets (CD3, CD4, CD8, TCR alpha beta and gamma delta), B (CD19) and NK cells (CD56) in blood and pleural fluid (n = 7) and ascitic fluid (n = 3) were determined. RESULTS:An increase was observed in total lymphocytes and all T subsets (CD3, CD4, CD8, alpha beta and gamma delta) in MAN group compared with CON group (p < 0.05 for all determinations). A progressive lymphopenia of total lymphocytes and CD4 was observed with more extensive disease, particularly in the DIS group (p < 0.05). No differences were observed between groups regarding B lymphocytes and NK cells. In pleural effusions and ascitic exudates an accumulation of T lymphocytes, mainly CD4, was observed, with no increase in gamma delta T lymphocytes. CONCLUSIONS:1) In patients with recent tuberculosis infection T lymphocytosis (total and subsets) occurs. 2) In the absence of HIV infection, a progressive lymphopenia occurs, particularly CD4, with extending disease. 3) In tuberculous pleural effusions and ascitic exudates and accumulation of CD4 T lymphocytes occurs, but not TCR gamma delta lymphocytes.
journal_name
Rev Clin Espjournal_title
Revista clinica espanolaauthors
Montes Santiago J,Gambón Deza F,Pacheco Carracedo M,Cerdá Mota Tsubject
Has Abstractpub_date
1996-04-01 00:00:00pages
223-7issue
4eissn
0014-2565issn
1578-1860journal_volume
196pub_type
杂志文章abstract::The understanding of the causes for hyperamylasemia is of great importance when focusing on the differential diagnosis of acute pancreatitis. Among the causes for hyperamylasemia, special interest is given to macroamylasemia not only because it is poorly understood, but also because we are lacking national studies. In...
journal_title:Revista clinica espanola
pub_type: 杂志文章,评审
doi:
更新日期:1989-05-01 00:00:00
abstract::The epithelial neoplasias associated to monoclonal gammapathy (GM) seen in a general hospital over a period of six years are reviewed. 8 cases were detected, 2 of which behaved as a second neoplasia since they occurred in patients previously diagnosed of multiple myeloma. The incidence and characteristics of the monoc...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Basing heart failure (HF) classification on the echocardiographic values of left ventricular ejection fraction (LVEF) has been useful in defining two sub-types of HF: HF with reduced LVEF and HF with preserved LVEF. A new category has recently been defined: HF with midrange LVEF (40-49%). When current information is t...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2017.01.013
更新日期:2017-01-01 00:00:00
abstract::Central nervous system compromise is a major cause of morbidity and mortality in SLE. The clinical picture of cerebral cryptococcosis is non-specific and can be mistaken for lupic activity. A retrospective study was undertaken with 10 patients with SLE and cryptococcal meningitis compiled in a 23-year period. The most...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the scientific output in Biomedicine and Health Sciences in Andalusia in the context of the published works on the national scientific output in the last few years. MATERIAL:Descriptive study with seven different information sources: a) final Report of the Experts Committee on Documentation from...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::The aim or our study was to evaluate the main clinical and etiological features or primary acute pericarditis with severe pericardial effusion without cardiac tamponade. Our experience included 35 patients with this problem diagnosed in the last 5 years. Patients with a previous potential etiology for acute pericardit...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/s0014-2565(06)72744-8
更新日期:2006-03-01 00:00:00
abstract::A retrospective study is presented of 19 patients who suffered Hypercortisolism who were examined by adrenal gammagraphy, echography, and CT scan in order to evaluate the usefulness of gammagraphy in the diagnostic approximation of this pathology. The gammagraphy findings had an excellent correlation with anatomopatho...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:Our objective was that of describing a series of episodes of upper limb deep venous thrombosis, with special emphasis on the incidence of posthrombotic syndrome and its impact in the quality of life of the patients. METHODS:33 episodes (29 patients) of upper limb deep venous thrombosis were studied, between ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1157/13070751
更新日期:2005-01-01 00:00:00
abstract::We have reviewed the clinical histories of 1,815 immunocompromised patients seen in "La Paz Hospital" over a period of 6 years, in order to study the incidence and clinical forms of tuberculosis (TB) in this group of patients. We have distributed the patients into three groups: Group A: 1,372 patients with neoplasia, ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Diabetes mellitus (DM) is characterized by a hypercoagulability state and many of these disorders are corrected with adequate metabolic control. The goal of this study was to assess diverse hemostatic and fibrinolytic parameters in 12 insulin-dependent (IDDM) metabolically controlled patients without vascular lesions ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:To estimate the use of resources and costs of health care to patients infected with the human immunodeficiency virus (HIV). METHODS:Prospective study in university hospital in Catalonia including 166 patients. AIDS was defined following 1987 criteria of the Centers for Disease Control. AIDS phase was divide...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract:UNLABELLED:Wolfram's syndrome (SW): diabetes mellitus (DM), diabetes insipidus (DI), blindness and deafness, is multiorganic, hereditary and uncommon. Mitochondrial dysfunction damages the oxidative pathway. OBJECTIVE:To analyze the clinical characteristics, diagnostic delay in constituent diseases and early diagnosti...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1157/13090481
更新日期:2006-07-01 00:00:00
abstract::Two cases of confirmed tuberculous Addison disease, with an increase in size of the adrenal glands are presented. One patient presented also a renal adenocarcinoma; this association is very rare given the small frequency of these diseases. Based on these two cases we emphasize the utility of puncture aspiration with a...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To summarise the evidence on interventions aimed at optimising the drug treatment of hospitalised elderly patients. MATERIAL AND METHODS:We conducted a search in the main medical literature databases, selecting prospective studies of hospitalised patients older than 65 years who underwent interventions aimed...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2016.01.005
更新日期:2016-05-01 00:00:00
abstract::The clinical histories of all the patients with hemoptysis who underwent bronchofibroscopy (FB) during a period of 5 years (1981-1986) are revised. 25.6% (108 out of 702) of the endoscopic explorations were performed in patients without radiographic pleuropulmonary abnormalities with a definite pathology. In these pat...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) encompasses a group of diseases characterized by chronic airway obstruction. This broad diagnostic umbrella includes several clinical phenotypes that overlap and respond differently to each type of therapeutic intervention. Roflumilast is a drug belonging to the new therape...
journal_title:Revista clinica espanola
pub_type: 杂志文章,评审
doi:10.1016/S0014-2565(11)70008-X
更新日期:2011-03-01 00:00:00
abstract::Pneumonia due to Pneumocystis carinii (PC) is characterized, in most cases, by the existence of infiltrates of interstitium or bilateral interstitium-alveolar type on the thorax radiography. However atypical radiological findings associated with this type of opportunistic infection are being described more and more fr...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::The clinical records of patients attended at emergency hospitals in fifteen hospitals in Madrid, Valencia and Gran Canaria during 1994 were retrospectively analyzed. Seventy-three emergencies related to the consumption of design drugs, hallucinogens or amphetamines (100 times lower than because of opiates or cocaine) ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the available evidence on the validity, diagnostic accuracy and clinical utility of the multitarget DNA test in faeces (Cologuard™) for screening for colorectal cancer (CRC). MATERIAL AND METHODS:A systematic review was performed by consulting MedLine, EMBASE and Web of S...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2015.08.002
更新日期:2015-12-01 00:00:00
abstract::The presence of macroamylasemia should be considered in the differential diagnosis of hyperamylasemia associated with acute abdominal pain, with suspect of pancreatitis. This uncommon and poorly known abnormality is defined as a blinding of serum amylase to certain proteins forming a circulating macrocomplex which pre...
journal_title:Revista clinica espanola
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-01 00:00:00
abstract::After recognizing smoking habit as a relevant problem in our media, the complex implications of this type of lifestyle are commented. After revising the main obstacles for achieving primary health care preventive measures not only for the patient, who frequently looks for a "treatment", but also for the professional w...
journal_title:Revista clinica espanola
pub_type: 杂志文章,评审
doi:
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVES:To describe the evolution of smoking habits in the general population of Barcelona from 1983 to 1992 and motivation of smokers and the perceived social pressure to leave smoking in 1992. DESIGN:Cross-sectional descriptive study of trends. PLACE AND PARTICIPANTS: From 1983 to 1992 two health surveys were con...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::A case is presented of Cushing's syndrome due to macronodular bilateral adrenal hyperplasia which is ACTH-independent as was demonstrated by the undetectable basal and after stimulation with metoprolol ACTH plasma levels. High cortisol levels is associated in this patient with empty sella turcica and anterior panhypop...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract::Two thousand and seventy simultaneous determinations of glucose, glucosylated hemoglobin (HbA1) and plasma fructosamine have been performed in 519 diabetic patients in order to obtain a follow up index and metabolic profile. This retrospective study points out the difficulty of achieving a good metabolic control in di...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:To prospectively and comparatively study the usefulness of urine (viruria) and blood (antigenemia pp65 and culture) (viremia) for the diagnosis of cytomegalovirus (CMV) infection in renal transplant (RT) recipients. MATERIAL AND METHODS:All RT recipients at our hospital were studied from January 1995 to Dece...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::A case of gastroenteritis due to Giardia lamblia with severe dehydration and complicated with arterial thrombosis, accompanied by eosinophilia and increased serum IgE levels, is presented. The relationship between Giardia and eosinophilia and allergic manifestations is discussed as well as its pathogenesis. ...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract:UNLABELLED:An inappropriate hospital use, defined as hospital utilization that could have been occurred at a lower attending level or in less time, increases costs, creates inefficient management and influences on attending quality. The objective of this work was to evaluate the appropriateness and inappropriateness of...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:The presence of surface antigen of hepatitis B (HBsAg) virus in serum from recently vaccinated adults has been scarcely investigated. In this work, after the detection by chance of seven HBsAg-positive patients on hemodialysis who reported recent hepatitis B vaccination, a prospective study was undertaken to...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract:INTRODUCTION:In decompensated heart failure (HF), both acute kidney injury (AKI) and high Galectina-3 (Gal-3) levels have been associated with poorer outcomes. Plasma Gal-3 levels are affected by renal function; however, the potential role of Gal-3 as a predictor of AKI has not been established. METHODS:We measured Ga...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:10.1016/j.rce.2018.10.004
更新日期:2019-01-01 00:00:00
abstract::Aluminium is a toxic metal of known importance in patients with chronic renal failure on hemodialysis, with a gastrointestinal absorption modulated by several factors including gastric pH which modifies the solubility of Aluminium hydroxide and can increase its absorption. We studied twenty six patients with normal re...
journal_title:Revista clinica espanola
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00