[Transient blood surface antigens of hepatitis B in patients on hemodialysis].

Abstract:

BACKGROUND:The presence of surface antigen of hepatitis B (HBsAg) virus in serum from recently vaccinated adults has been scarcely investigated. In this work, after the detection by chance of seven HBsAg-positive patients on hemodialysis who reported recent hepatitis B vaccination, a prospective study was undertaken to verify the presence and duration of post-vacunal antigenemia. PATIENTS AND METHODS:Nineteen non-selected patients on hemodialysis were followed for serologic markers of hepatitis B, after receiving a dose of the recombinant vaccine (Engerix B) according to their vaccination schedule. Enzyme-immunoassay techniques were used for the study of serologic markers, and the reactivity of HBsAg was confirmed by means of a neutralization assay with specific anti-HBs antibodies. RESULTS:After the administration of one vaccine dose, 31.5% of patients were HBsAg positive at least once. Antigenemia was identified more frequently 2 to 4 days (83.3%) after immunization. In all cases antigenemia was transient and had cleared after 11 days of vaccination. The follow-up of serologic markers revealed the absence of infection with virus B. Only 16.6% of patients with transient antigenemia responded to vaccination (titer of anti-HBs > or = 10 mIU/ml), while the corresponding percentage in the group of HBsAg-negative patients was 69.2% (p < 0.05). All patients were HCV and HIV negative. CONCLUSIONS:A high frequency of post-vacunal antigenemia is reported in patients on hemodialysis, in absence of virus B infection as well as the possible relationship between the presence of transient antigenemia and the non-responder status.

journal_name

Rev Clin Esp

journal_title

Revista clinica espanola

authors

Santana Rodríguez OE,Morillas Jarillo C,Esparza Martín N,Toledo González A,Checa Andrés MD,Martín Sánchez AM

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

198-201

issue

4

eissn

0014-2565

issn

1578-1860

journal_volume

199

pub_type

杂志文章
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    pub_type: 杂志文章

    doi:

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  • [Seroepidemiology of Bartonella henselae infection in a risk group].

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    pub_type: 杂志文章

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