Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins.

abstract：:G protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors. They can exist and act as dimers, but the requirement of dimers for agonist-induced signal initiation and structural dynamics remains largely unknown. Frizzled 6 (FZD6) is a member of Class F GPCRs, which bind WNT proteins to ...

journal_title：Nature communications

authors： Petersen J,Wright SC,Rodríguez D,Matricon P,Lahav N,Vromen A,Friedler A,Strömqvist J,Wennmalm S,Carlsson J,Schulte G

更新日期：2017-08-09 00:00:00

abstract：:Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...

journal_title：Nature communications

authors： Thapa P,Das J,McWilliams D,Shapiro M,Sundsbak R,Nelson-Holte M,Tangen S,Anderson J,Desiderio S,Hiebert S,Sant'angelo DB,Shapiro VS

更新日期：2013-01-01 00:00:00

abstract：:Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of ...

journal_title：Nature communications

authors： Adhireksan Z,Palermo G,Riedel T,Ma Z,Muhammad R,Rothlisberger U,Dyson PJ,Davey CA

更新日期：2017-03-30 00:00:00

abstract：:Mei (Prunus mume) is an ornamental woody plant that has been domesticated in East Asia for thousands of years. High diversity in floral traits, along with its recent genome sequence, makes mei an ideal model system for studying the evolution of woody plants. Here, we investigate the genetic architecture of floral trai...

journal_title：Nature communications

authors： Zhang Q,Zhang H,Sun L,Fan G,Ye M,Jiang L,Liu X,Ma K,Shi C,Bao F,Guan R,Han Y,Fu Y,Pan H,Chen Z,Li L,Wang J,Lv M,Zheng T,Yuan C,Zhou Y,Lee SM,Yan X,Xu X,Wu R,Chen W,Cheng T

更新日期：2018-04-27 00:00:00

abstract：:Osteoderms are bones embedded within the dermis, and are common to select members of most major tetrapod lineages. The largest known animals that bear osteoderms are members of Titanosauria, a diverse clade of sauropod dinosaurs. Here we report on two titanosaur osteoderms recovered from the Upper Cretaceous Maevarano...

journal_title：Nature communications

authors： Curry Rogers K,D'Emic M,Rogers R,Vickaryous M,Cagan A

更新日期：2011-11-29 00:00:00

abstract：:Blends of electron-donating and -accepting organic semiconductors are widely used as photoactive materials in next-generation solar cells and photodetectors. The yield of free charges in these systems is often determined by the separation of interfacial electron-hole pairs, which is expected to depend on the ability o...

journal_title：Nature communications

authors： Stolterfoht M,Armin A,Shoaee S,Kassal I,Burn P,Meredith P

更新日期：2016-06-21 00:00:00

abstract：:Gene-targeted animal models that are generated by injecting Cas9 and sgRNAs into zygotes are often accompanied by undesired double-strand break (DSB)-induced byproducts and random biallelic targeting due to uncontrollable Cas9 targeting activity. Here, we establish a parental allele-specific gene-targeting (Past-CRISP...

journal_title：Nature communications

authors： Li Y,Weng Y,Bai D,Jia Y,Liu Y,Zhang Y,Kou X,Zhao Y,Ruan J,Chen J,Yin J,Wang H,Teng X,Wang Z,Liu W,Gao S

更新日期：2020-09-14 00:00:00

abstract：:Recently rediscovered black phosphorus is a layered semiconductor with promising electronic and photonic properties. Dynamic control of its bandgap can allow for the exploration of new physical phenomena. However, theoretical investigations and photoemission spectroscopy experiments indicate that in its few-layer form...

journal_title：Nature communications

authors： Deng B,Tran V,Xie Y,Jiang H,Li C,Guo Q,Wang X,Tian H,Koester SJ,Wang H,Cha JJ,Xia Q,Yang L,Xia F

更新日期：2017-04-19 00:00:00

abstract：:Assembly of infectious influenza A viruses (IAV) is a complex process involving transport from the nucleus to the plasma membrane. Rab11A-containing recycling endosomes have been identified as a platform for intracellular transport of viral RNA (vRNA). Here, using high spatiotemporal resolution light-sheet microscopy ...

journal_title：Nature communications

authors： Bhagwat AR,Le Sage V,Nturibi E,Kulej K,Jones J,Guo M,Tae Kim E,Garcia BA,Weitzman MD,Shroff H,Lakdawala SS

更新日期：2020-01-07 00:00:00

abstract：:Supercooling of aqueous solutions is a fundamentally and practically important physical phenomenon with numerous applications in biopreservation and beyond. Under normal conditions, heterogeneous nucleation mechanisms critically prohibit the simultaneous long-term (> 1 week), large volume (> 1 ml), and low temperature...

journal_title：Nature communications

authors： Huang H,Yarmush ML,Usta OB

更新日期：2018-08-10 00:00:00

abstract：:Humans survive and thrive through social exchange. Yet, social dependency also comes at a cost. Perceived social isolation, or loneliness, affects physical and mental health, cognitive performance, overall life expectancy, and increases vulnerability to Alzheimer's disease-related dementias. Despite severe consequence...

journal_title：Nature communications

authors： Spreng RN,Dimas E,Mwilambwe-Tshilobo L,Dagher A,Koellinger P,Nave G,Ong A,Kernbach JM,Wiecki TV,Ge T,Li Y,Holmes AJ,Yeo BTT,Turner GR,Dunbar RIM,Bzdok D

更新日期：2020-12-15 00:00:00

abstract：:Repeated cell divisions and aging impair stem cell function. However, the mechanisms by which this occurs are not fully understood. Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging. Pot1a is...

journal_title：Nature communications

authors： Hosokawa K,MacArthur BD,Ikushima YM,Toyama H,Masuhiro Y,Hanazawa S,Suda T,Arai F

更新日期：2017-10-06 00:00:00

abstract：:The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR st...

journal_title：Nature communications

authors： Chakravarty D,Sboner A,Nair SS,Giannopoulou E,Li R,Hennig S,Mosquera JM,Pauwels J,Park K,Kossai M,MacDonald TY,Fontugne J,Erho N,Vergara IA,Ghadessi M,Davicioni E,Jenkins RB,Palanisamy N,Chen Z,Nakagawa S,Hirose T

更新日期：2014-11-21 00:00:00

abstract：:Because the surface-to-volume ratio of quasi-two-dimensional materials is extremely high, understanding their surface characteristics is crucial for practically controlling their intrinsic properties and fabricating p-type and n-type layered semiconductors. Van der Waals crystals are expected to have an inert surface ...

journal_title：Nature communications

authors： Siao MD,Shen WC,Chen RS,Chang ZW,Shih MC,Chiu YP,Cheng CM

更新日期：2018-04-12 00:00:00

abstract：:The ever-increasing speed and resolution of modern microscopes make the storage and post-processing of images challenging and prevent thorough statistical analyses in developmental biology. Here, instead of deploying massive storage and computing power, we exploit the spherical geometry of zebrafish embryos by computi...

journal_title：Nature communications

authors： Schmid B,Shah G,Scherf N,Weber M,Thierbach K,Campos CP,Roeder I,Aanstad P,Huisken J

更新日期：2013-01-01 00:00:00

abstract：:Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glyco...

journal_title：Nature communications

authors： Wang Y,Quinsaat JEQ,Ono T,Maeki M,Tokeshi M,Isono T,Tajima K,Satoh T,Sato SI,Miura Y,Yamamoto T

更新日期：2020-11-30 00:00:00

abstract：:Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluripotent stem cells (...

journal_title：Nature communications

authors： Vandoorne T,Veys K,Guo W,Sicart A,Vints K,Swijsen A,Moisse M,Eelen G,Gounko NV,Fumagalli L,Fazal R,Germeys C,Quaegebeur A,Fendt SM,Carmeliet P,Verfaillie C,Van Damme P,Ghesquière B,De Bock K,Van Den Bosch L

更新日期：2019-09-12 00:00:00

abstract：:Matter-wave interferometry performed with massive objects elucidates their wave nature and thus tests the quantum superposition principle at large scales. Whereas standard quantum theory places no limit on particle size, alternative, yet untested theories--conceived to explain the apparent quantum to classical transit...

journal_title：Nature communications

authors： Bateman J,Nimmrichter S,Hornberger K,Ulbricht H

更新日期：2014-09-02 00:00:00

abstract：:Quantum metrology bears a great promise in enhancing measurement precision, but is unlikely to become practical in the near future. Its concepts can nevertheless inspire classical or hybrid methods of immediate value. Here we demonstrate NOON-like photonic states of m quanta of angular momentum up to m=100, in a setup...

journal_title：Nature communications

authors： D'Ambrosio V,Spagnolo N,Del Re L,Slussarenko S,Li Y,Kwek LC,Marrucci L,Walborn SP,Aolita L,Sciarrino F

更新日期：2013-01-01 00:00:00

abstract：:Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor ce...

journal_title：Nature communications

authors： Duncan GJ,Manesh SB,Hilton BJ,Assinck P,Liu J,Moulson A,Plemel JR,Tetzlaff W

更新日期：2018-08-03 00:00:00

abstract：:Cytidine base editors (CBEs) and adenine base editors (ABEs), composed of a cytidine deaminase or an evolved adenine deaminase fused to Cas9 nickase, enable the conversion of C·G to T·A or A·T to G·C base pair in organisms, respectively. Here, we show that BE3 and ABE7.10 systems can achieve a targeted mutation effici...

journal_title：Nature communications

authors： Liu Z,Chen M,Chen S,Deng J,Song Y,Lai L,Li Z

更新日期：2018-07-13 00:00:00

abstract：:Although soluble inhibitors are frequently used to block cell binding to the extracellular matrix (ECM), mechanical stretching of a protein fibre alone can physically destroy a cell-binding site. Here, we show using binding assays and steered molecular dynamics that mechanical tension along fibronectin (Fn) fibres cau...

journal_title：Nature communications

authors： Chabria M,Hertig S,Smith ML,Vogel V

更新日期：2010-01-01 00:00:00

abstract：:Recently, metasurfaces composed of artificially fabricated subwavelength structures have shown remarkable potential for the manipulation of light with unprecedented functionality. Here, we first demonstrate a metasurface application to realize a compact near-eye display system for augmented reality with a wide field o...

journal_title：Nature communications

authors： Lee GY,Hong JY,Hwang S,Moon S,Kang H,Jeon S,Kim H,Jeong JH,Lee B

更新日期：2018-11-01 00:00:00

abstract：:Protein tyrosine O-sulfation (PTS) plays a crucial role in extracellular biomolecular interactions that dictate various cellular processes. It also involves in the development of many human diseases. Regardless of recent progress, our current understanding of PTS is still in its infancy. To promote and facilitate rele...

journal_title：Nature communications

authors： He X,Chen Y,Beltran DG,Kelly M,Ma B,Lawrie J,Wang F,Dodds E,Zhang L,Guo J,Niu W

更新日期：2020-09-24 00:00:00

abstract：:Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium falciparum laboratory-adapted strains (mean IC50 32 nM), Ugandan field isolates (mean ex vivo IC50 64 nM), and murine P. berghei and P. falciparum infections (day 4 E...

journal_title：Nature communications

authors： Sonoiki E,Ng CL,Lee MC,Guo D,Zhang YK,Zhou Y,Alley MR,Ahyong V,Sanz LM,Lafuente-Monasterio MJ,Dong C,Schupp PG,Gut J,Legac J,Cooper RA,Gamo FJ,DeRisi J,Freund YR,Fidock DA,Rosenthal PJ

更新日期：2017-03-06 00:00:00

abstract：:Striated muscle contraction is regulated by the translocation of troponin-tropomyosin strands over the thin filament surface. Relaxation relies partly on highly-favorable, conformation-dependent electrostatic contacts between actin and tropomyosin, which position tropomyosin such that it impedes actomyosin association...

journal_title：Nature communications

authors： Viswanathan MC,Schmidt W,Franz P,Rynkiewicz MJ,Newhard CS,Madan A,Lehman W,Swank DM,Preller M,Cammarato A

更新日期：2020-05-15 00:00:00

abstract：:Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the ...

journal_title：Nature communications

authors： Jin L,Feng X,Rong H,Pan Z,Inaba Y,Qiu L,Zheng W,Lin S,Wang R,Wang Z,Wang S,Liu H,Li S,Xie W,Li Y

更新日期：2013-01-01 00:00:00

abstract：:We establish a powerful poly(4-styrenesulfonate) (PSS)-treated strategy for sulfur vacancy healing in monolayer MoS2 to precisely and steadily tune its electronic state. The self-healing mechanism, in which the sulfur vacancies are healed spontaneously by the sulfur adatom clusters on the MoS2 surface through a PSS-in...

journal_title：Nature communications

authors： Zhang X,Liao Q,Liu S,Kang Z,Zhang Z,Du J,Li F,Zhang S,Xiao J,Liu B,Ou Y,Liu X,Gu L,Zhang Y

更新日期：2017-06-22 00:00:00

abstract：:Topological insulators do not allow conduction in the bulk, yet they support edge modes that travel along the boundary only in one direction, determined by the carried electron spin, with inherent robustness to defects and disorder. Topological insulators have inspired analogues in photonics and optics, in which one-w...

journal_title：Nature communications

authors： Khanikaev AB,Fleury R,Mousavi SH,Alù A

更新日期：2015-10-06 00:00:00

abstract：:16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging...

journal_title：Nature communications

authors： Moreau CA,Urchs SGW,Kuldeep K,Orban P,Schramm C,Dumas G,Labbe A,Huguet G,Douard E,Quirion PO,Lin A,Kushan L,Grot S,Luck D,Mendrek A,Potvin S,Stip E,Bourgeron T,Evans AC,Bearden CE,Bellec P,Jacquemont S

更新日期：2020-10-19 00:00:00