Inhibition of quorum-sensing-controlled virulence factors of Pseudomonas aeruginosa by Murraya koenigii essential oil: a study in a Caenorhabditis elegans infectious model.

abstract：PURPOSE:Antimicrobial resistance (AMR) is of increasing global concern, threatening to undermine recent progress in reducing child and neonatal mortality. Repurposing older antimicrobials is a prominent strategy to combat multidrug-resistant sepsis. A potential agent is fosfomycin, however, there is scarce data regardi...

journal_title：Journal of medical microbiology

authors： Williams PCM,Waichungo J,Gordon NC,Sharland M,Murunga S,Kamau A,Berkley JA

更新日期：2019-05-01 00:00:00

abstract：:Immunoblotting sera from cases of Streptococcus mutans or S. sobrinus endocarditis against an extract from S. sobrinus strain MUCOB 263 had identified three immunodominant antigenic bands at 190, 200 and 220 kDa. A lambda ZAPII DNA library was produced from the sheared genomic DNA of S. sobrinus MUCOB 263 and six iden...

journal_title：Journal of medical microbiology

authors： Brooks W,Burnie JP

更新日期：1994-05-01 00:00:00

abstract：:A novel spirochaete was isolated from a case of severe virulent ovine foot rot (SVOFR) by immunomagnetic separation with beads coated with polyclonal anti-treponemal antisera and prolonged anaerobic broth culture. The as yet unnamed treponeme differs considerably from the only other spirochaete isolated from ovine foo...

journal_title：Journal of medical microbiology

authors： Demirkan I,Carter SD,Winstanley C,Bruce KD,McNAIR NM,Woodside M,Hart CA

更新日期：2001-12-01 00:00:00

abstract：:A rabbit was immunised with a heat-killed vaccine prepared from strain 1142 of Staphylococcus epidermidis. The HA titres of the antisera against a surface-polysaccharide antigen extracted from the homologous strain were highest in the 2nd-4th weeks after immunisation and subsequently declined. Only a minor amount of 2...

journal_title：Journal of medical microbiology

authors： Yoshida K,Ichiman Y

更新日期：1978-11-01 00:00:00

abstract：:A detailed study was made of lambs aged 5--7 months naturally infected with Pasteurella haemolytica biotype T. In addition to the well known features of such infections, previously unreported necrotic lesions of the tonsil, oesophagus, pharynx and adjacent areas were consistently seen. Large numbers of P. haemolytica ...

journal_title：Journal of medical microbiology

authors： Dyson DA,Gilmour NJ,Angus KW

更新日期：1981-02-01 00:00:00

abstract：:During 2003, Vibrio cholerae O1 Ogawa was the predominant serotype among diarrhoeal patients admitted to different hospitals in India. With the exception of 3 strains from Kolkata, none of 172 strains examined exhibited resistance to tetracycline, but 45.7 % showed reduced susceptibility to ciprofloxacin. Extensive mo...

journal_title：Journal of medical microbiology

authors： Chatterjee S,Ghosh K,Raychoudhuri A,Pan A,Bhattacharya MK,Mukhopadhyay AK,Ramamurthy T,Bhattacharya SK,Nandy RK

更新日期：2007-06-01 00:00:00

abstract：:Human gastric epithelial immortalized GES-1 cells were infected with spiral and coccoid Helicobacter pylori. Scanning electron microscopy was used to determine the ability of the two forms of H. pylori to adhere to GES-1 cells. GES-1 cell apoptosis induced by coccoid and spiral H. pylori was analysed using flow cytome...

journal_title：Journal of medical microbiology

authors： Liu ZF,Chen CY,Tang W,Zhang JY,Gong YQ,Jia JH

更新日期：2006-08-01 00:00:00

abstract：:The determinant responsible for the ability of Bacteroides spp. to inhibit polymorph phagocytic killing of aerobic organisms has not yet been identified. Therefore, the roles of lipopolysaccharide and capsular polysaccharide of B. fragilis were investigated. Serum-resistant and serum-sensitive strains of Proteus mirab...

journal_title：Journal of medical microbiology

authors： Connolly JC,McLean C,Tabaqchali S

更新日期：1984-06-01 00:00:00

abstract：:Helicobacter trogontum is a micro-aerophilic urease-positive bacterium that has recently been isolated from the intestinal mucosa of rats. The purpose of this investigation was to study the ultrastructural details of this micro-organism in both pure culture and in the gastrointestinal tract of germ-free mice infected ...

journal_title：Journal of medical microbiology

authors： Moura SB,Mendes EN,Queiroz DM,Camargos ER,Evangelina M,Fonseca F,Rocha GA,Nicoli JR

更新日期：1998-06-01 00:00:00

abstract：:Clostridium difficile is a frequent cause of severe, recurrent, post-antibiotic diarrhoea and pseudomembranous colitis. Its pathogenicity is mediated mainly by two toxins, TcdA and TcdB. However, different adhesins have also been described as important colonization factors which are implicated in the first step of the...

journal_title：Journal of medical microbiology

authors： Barketi-Klai A,Hoys S,Lambert-Bordes S,Collignon A,Kansau I

更新日期：2011-08-01 00:00:00

abstract：:Screening for Chlamydia trachomatis infections can be performed on urine samples and genital swabs using molecular techniques. A novel approach was developed that combined an automated extraction procedure, an automated liquid-handling system and real-time PCR to detect C. trachomatis from urine or swabs. This novel r...

journal_title：Journal of medical microbiology

authors： Jaton K,Bille J,Greub G

更新日期：2006-12-01 00:00:00

abstract：:The aim of this study was to improve the identification of Mycobacterium species in the context of a UK teaching hospital. Real-time PCR assays were established to enable the rapid differentiation between Mycobacterium tuberculosis (MTB) complex and Mycobacterium species other than tuberculosis (MOTT), followed by 16S...

journal_title：Journal of medical microbiology

authors： Williams KJ,Ling CL,Jenkins C,Gillespie SH,McHugh TD

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Membrane fluidity to a large extent is governed by the presence of branched-chain fatty acids (BCFAs). Branched-chain α-keto acid dehydrogenase (BKD) is the key enzyme in BCFA synthesis. A Staphylococcus aureus BKD-deficient strain still produced substantial levels of BCFAs. Pyruvate dehydrogenase (PDH) with st...

journal_title：Journal of medical microbiology

authors： Singh VK,Sirobhushanam S,Ring RP,Singh S,Gatto C,Wilkinson BJ

更新日期：2018-04-01 00:00:00

abstract：:A slide agglutination technique identifying 10 serogroups of Clostridium difficile (A,B,C,D,F,G,H,I,K and X) has been described previously. In this study, we have used the hamster to compare the ability of the 10 serogroup reference strains to colonise and produce disease. Groups of four hamsters were each given a sin...

journal_title：Journal of medical microbiology

authors： Delmée M,Avesani V

更新日期：1990-10-01 00:00:00

abstract：:The toxic effects of the haemorrhagic toxin of Clostridium sporogenes were studied in mice, rats, guinea-pigs and rabbits, and in various cultured cells. In rabbits, but not in the other animals, intradermal injection with crude toxin and its injection into a ligated intestinal loop caused haemorrhage in both the skin...

journal_title：Journal of medical microbiology

authors： Hara-Kudo Y,Ogura A,Noguchi Y,Kumagai S

更新日期：1997-04-01 00:00:00

abstract：PURPOSE:Multidrug-resistant Klebsiella pneumoniae is a common nosocomial pathogen that plays an important role in ventilator-associated pneumonia (VAP). This study aimed to define the clonal relatedness of K. pneumoniae strains isolated from paediatric VAP in addition to those isolated from environmental samples. METH...

journal_title：Journal of medical microbiology

authors： Mohamed ER,Aly SA,Halby HM,Ahmed SH,Zakaria AM,El-Asheer OM

更新日期：2017-05-01 00:00:00

abstract：:Bedaquiline (BDQ) has been proven to be effective in the treatment of multidrug-resistant tuberculosis. We hypothesized that BDQ could be a potential agent to treat nontuberculous mycobacterial (NTM) infection. The objective of this study was to evaluate the in vitro activity of BDQ against rapidly growing mycobacteri...

journal_title：Journal of medical microbiology

authors： Aguilar-Ayala DA,Cnockaert M,André E,Andries K,Gonzalez-Y-Merchand JA,Vandamme P,Palomino JC,Martin A

更新日期：2017-08-01 00:00:00

abstract：:Nucleic acid amplification techniques (NAATs) have been demonstrated to make significant improvements in the diagnosis of tuberculosis (TB), particularly in the time to diagnosis and the diagnosis of smear-negative TB. The BD ProbeTec strand displacement amplification (SDA) system for the diagnosis of pulmonary and no...

journal_title：Journal of medical microbiology

authors： McHugh TD,Pope CF,Ling CL,Patel S,Billington OJ,Gosling RD,Lipman MC,Gillespie SH

更新日期：2004-12-01 00:00:00

abstract：:The bactericidal activity of compound DR-3355, an optically active isomer of ofloxacin, was measured against Escherichia coli, Staphylococcus aureus and S. epidermidis, in nutrient broth and in phosphate-buffered saline. DR-3355 was found to be approximately twice as active as ofloxacin in terms of the concentration a...

journal_title：Journal of medical microbiology

authors： Lewin CS,Amyes SG

更新日期：1989-11-01 00:00:00

abstract：:The potential of exocellular carbohydrate antigens of Staphylococcus epidermidis as markers of infection in bone was investigated by immunoblotting and enzyme-linked immunosorbent assay (ELISA). Exocellular antigens were prepared by gel filtration chromatography of concentrated brain heart infusion culture supernates....

journal_title：Journal of medical microbiology

authors： Lambert PA,Van Maurik A,Parvatham S,Akhtar Z,Fraise AP,Krikler SJ

更新日期：1996-05-01 00:00:00

abstract：:Mycobacterium bovis is a pathogen of cattle. The unpasteurized milk of affected cattle is a source of infection in humans. Despite the screening of cattle and the pasteurization of milk, M bovis has not been eradicated. A high index of clinical suspicion is needed in symptomatic patients with a history of possible exp...

journal_title：Journal of medical microbiology

authors： Bilal S,Iqbal M,Murphy P,Power J

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Catheter-related bloodstream infections (CRBSIs) are among the most common hospital-acquired infections. We aimed to survey methicillin resistance, biofilm production and susceptibility to vancomycin, linezolid and other antibiotics for staphylococci isolated from CRBSIs. METHODOLOGY:Fifty-eight isolates [20 S...

journal_title：Journal of medical microbiology

authors： Hashem AA,Abd El Fadeal NM,Shehata AS

更新日期：2017-06-01 00:00:00

abstract：:Streptococcus pneumoniae remains a leading cause of serious paediatric disease. However, there are few published epidemiological data regarding invasive pneumococcal disease (IPD) in many countries in South East Asia, including Singapore. Baseline data for IPD are essential to inform policy regarding pneumococcal conj...

journal_title：Journal of medical microbiology

authors： Jefferies JMC,Tee WSN,Clarke SC

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:An observational study was performed to investigate the carriage rate and serotypes of Streptococcus pneumoniae in the 13-valent pneumococcal conjugate vaccine (PCV13) era in Taiwan. METHODOLOGY:From March 2014 to March 2015 a total of 500 healthy children and their households (631 adults) were enrolled from t...

journal_title：Journal of medical microbiology

authors： Janapatla RP,Su LH,Chen HH,Chang HJ,Tsai TC,Chen PY,Chen CL,Chiu CH

更新日期：2017-06-01 00:00:00

abstract：:The intrathecal synthesis of IgM and IgG antibodies to Borrelia burgdorferi sonicate, to recombinant flagellin (41 kDa) and to a tryptic peptide of the flagellin (14-kDa fragment) was determined by ELISA in paired cerebrospinal fluid (CSF) and serum samples from 35 patients with Lyme neuroborreliosis (LNB) and in 10 p...

journal_title：Journal of medical microbiology

authors： Kaiser R,Rasiah C,Gassmann G,Vogt A,Lücking CH

更新日期：1993-10-01 00:00:00

abstract：:Limited digestion of staphylococcal enterotoxin B (SEB) with trypsin resulted in the generation of a 12-Kda amino-terminal fragment and a 17-Kda carboxy-terminal fragment which were isolated by preparative iso-electric focusing. The carboxy-terminal fragment exhibited significant mitogenic activity for murine splenocy...

journal_title：Journal of medical microbiology

authors： Binek M,Newcomb JR,Rogers CM,Rogers TJ

更新日期：1992-03-01 00:00:00

abstract：:The microbiota of the human oropharynx plays an important role in health through involvement in the aetiology of infection and the carriage of adventitious pathogens. Despite this, there are few models available for the preclinical assessment of novel antimicrobials directed to the human throat. We have profiled bacte...

journal_title：Journal of medical microbiology

authors： Humphreys GJ,McBain AJ

更新日期：2013-06-01 00:00:00

abstract：:The ability of Proteus mirabilis to produce the bacteriocin, proticine 3, is found almost exclusively in strains that cause severe infections of the upper urinary tract. Proticine 3 was purified from lysates of mitomycin C-induced cultures. Biological activity was associated with structures resembling bacteriophage ta...

journal_title：Journal of medical microbiology

authors： Senior BW

更新日期：1983-08-01 00:00:00

abstract：:A total of 110 clinical isolates of Vibrio cholerae O1 biotype El Tor serotype Ogawa isolated in a recent outbreak from different districts of Teheran, Iran, was subjected to 99 carbon source utilisation tests, ribotyping and toxinogenotyping. PCR showed that the genes encoding cholera toxin (ctxA), toxin co-regulated...

journal_title：Journal of medical microbiology

authors： Pourshafie MR,Grimont F,Saifi M,Grimont PAD

更新日期：2000-12-01 00:00:00

abstract：:In tests of bactericidal action against H. influenzae type b strains isolated from patients with meningitis, chloramphenicol was found to be far more reliable than ampicillin in dealing with large inocula, and more rapidly effective against both large and relatively small inocula. These findings provide a laboratory e...

journal_title：Journal of medical microbiology

authors： Turk DC

更新日期：1977-02-01 00:00:00