THE IMPACT OF CIRCADIAN RHYTHMS ON MEDICAL IMAGING AND RADIOTHERAPY REGIMES FOR THE PAEDIATRIC PATIENT.

Abstract:

:Daily rhythmic changes are found in cellular events in cell cycle, DNA repair, apoptosis and angiogenesis in both normal and tumour tissue, as well as in enzymatic activity and drug metabolism. In this paper, we hypothesize that circadian rhythms need to be considered in radiation protection and optimization in personalized medicine, especially for paediatric care. The sensitivity of the eye lens to ionizing radiation makes the case for limiting damage to the lens epithelium by planning medical radio-imaging procedures for the afternoon, rather than the morning. Equally, the tumour and normal tissue response to radiotherapy is also subject to diurnal variation enabling optimization of time of treatment.

journal_name

Radiat Prot Dosimetry

authors

Forssell-Aronsson E,Quinlan RA

doi

10.1093/rpd/ncw328

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

16-20

issue

1-3

eissn

0144-8420

issn

1742-3406

pii

ncw328

journal_volume

173

pub_type

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