Simulation of DNA damage after proton and low LET irradiation.

Abstract:

:A module for proton track structure simulation in liquid water was implemented in the biophysical model PARTRAC. Simulated tracks of energy deposition events from the radiation under investigation were superimposed on a higher-order DNA target model describing the whole genome inside a human cell. The parameters controlling DNA damage from direct and indirect effects were adapted to agree with yields and pathway contributions derived from gamma ray irradiation experiments. Single and double strand break (DSB) induction was simulated for irradiations by protons, photons and electrons over a wide range of initial energies. The relative biological effectiveness for DSB induction after proton irradiation was found to rise from 1.2 at 5 keV.micron-1 to about 2.5 at 70 keV.micron-1. About half of this growth resulted from an increased production of DSB clusters associated with small (< 10 kbp) fragments.

journal_name

Radiat Prot Dosimetry

authors

Friedland W,Bernhardt P,Jacob P,Paretzke HG,Dingfelder M

doi

10.1093/oxfordjournals.rpd.a006848

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

99-102

issue

1-4

eissn

0144-8420

issn

1742-3406

journal_volume

99

pub_type

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