Abstract:
:Dose and dose rate effectiveness factors (DDREF), in conjunction with other weighting factors, are commonly used to scale atomic bomb survivor data in order to establish limits for occupational radiation exposure, including radiation exposure in space. We use some well-known facts about the microscopic pattern of energy deposition of high-energy heavy ions, and about the dose rate dependence of chemical reactions initiated by radiation, to show that DDREF are likely to vary significantly as a function of particle type and energy, cell, tissue, and organ type, and biological end point. As a consequence, we argue that validation of DDREF by conventional methods, e.g. irradiating animal colonies and compiling statistics of cancer mortality, is not appropriate. However, the use of approaches derived from information theory and thermodynamics is a very wide field, and the present work can only be understood as a contribution to an ongoing discussion.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Schimmerling W,Cucinotta FAdoi
10.1093/rpd/ncl464subject
Has Abstractpub_date
2006-01-01 00:00:00pages
349-53issue
1-4eissn
0144-8420issn
1742-3406pii
ncl464journal_volume
122pub_type
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