A ternary complex comprising transportin1, Rab8 and the ciliary targeting signal directs proteins to ciliary membranes.

abstract：:Neutrophils enter sites of inflammation by crossing the endothelial lining of the blood vessel wall. VE-cadherin is an endothelial specific, homophilic adhesion molecule located at the lateral cell surface. We have generated a monoclonal antibody against mouse VE-cadherin which inhibits electrical resistance of endoth...

journal_title：Journal of cell science

authors： Gotsch U,Borges E,Bosse R,Böggemeyer E,Simon M,Mossmann H,Vestweber D

更新日期：1997-03-01 00:00:00

abstract：:In situ hybridization has become a powerful technique for dissecting nuclear structure. By localizing nucleic acids with high precision, it is possible to infer the native structure of chromosomes, replication factories and transcript processing complexes. To increase the value of this technique, we have established t...

journal_title：Journal of cell science

authors： Gunawardena S,Heddle E,Rykowski MC

更新日期：1995-05-01 00:00:00

abstract：:We have explored the biological function of a surface glycoprotein (GP72) of Trypanosoma cruzi by studying a null mutant parasite, generated by targeted gene deletion. GP72 deletion affected parasite morphology in several stages of the life cycle. Insect midgut (epimastigote) forms had a detached flagellum (apomastigo...

journal_title：Journal of cell science

authors： de Jesus AR,Cooper R,Espinosa M,Gomes JE,Garcia ES,Paul S,Cross GA

更新日期：1993-12-01 00:00:00

abstract：:Electrical synapses (gap junctions) rapidly transmit signals between neurons and are composed of connexins. In neurons, connexin36 (Cx36) is the most abundant isoform; however, the mechanisms underlying formation of Cx36-containing electrical synapses are unknown. We focus on homocellular and heterocellular gap juncti...

journal_title：Journal of cell science

authors： Meyer A,Hilgen G,Dorgau B,Sammler EM,Weiler R,Monyer H,Dedek K,Hormuzdi SG

更新日期：2014-03-15 00:00:00

abstract：:Toxoplasma gondii is an obligate intracellular parasite that infects a wide variety of vertebrate cells including macrophages. We have used a combination of video microscopy and fluorescence localization to examine the entry of Toxoplasma into macrophages and nonphagocytic host cells. Toxoplasma actively invaded host ...

journal_title：Journal of cell science

authors： Morisaki JH,Heuser JE,Sibley LD

更新日期：1995-06-01 00:00:00

abstract：:The signal recognition particle (SRP) is a ribonucleoprotein machine that controls the translation and intracellular sorting of membrane and secreted proteins. The SRP contains a core RNA subunit with which six proteins are assembled. Recent work in both yeast and mammalian cells has identified the nucleolus as a poss...

journal_title：Journal of cell science

authors： Sommerville J,Brumwell CL,Politz JC,Pederson T

更新日期：2005-03-15 00:00:00

abstract：:BMP2 stimulates bone formation and signals preferably through BMP receptor (BMPR) 1A, whereas GDF5 is a cartilage inducer and signals preferably through BMPR1B. Consequently, BMPR1A and BMPR1B are believed to be involved in bone and cartilage formation, respectively. However, their function is not yet fully clarified....

journal_title：Journal of cell science

authors： Mang T,Kleinschmidt-Doerr K,Ploeger F,Schoenemann A,Lindemann S,Gigout A

更新日期：2020-08-21 00:00:00

abstract：:Cell chemotaxis, such as migration of fibroblasts towards growth factors during development and wound healing, requires precise spatial coordination of signalling events. Phosphoinositides and signalling enzymes involved in their generation and hydrolysis have been implicated in regulation of chemotaxis; however, the ...

journal_title：Journal of cell science

authors： Martins M,Warren S,Kimberley C,Margineanu A,Peschard P,McCarthy A,Yeo M,Marshall CJ,Dunsby C,French PM,Katan M

更新日期：2012-12-01 00:00:00

abstract：:Cryo-ultramicrotomy and X-ray microanalysis were used to study the elemental composition of HeLa S3 cells. Quantitation was achieved by reference to elemental standards of known concentration made up in 25% gelatin. Analysis of standards showed linear calibration for each of the elements studied: Na, P, S, Cl, K. Stan...

journal_title：Journal of cell science

authors： Warley A,Stephen J,Hockaday A,Appleton TC

更新日期：1983-03-01 00:00:00

abstract：:In the fission yeast Schizosaccharomyces pombe, the protein kinase Chk1 has an essential role in transducing a delay signal to the cell cycle machinery in the presence of DNA damage. Fission yeast cells lacking the chk1 gene do not delay progression of the cell cycle in response to damage and are thus sensitive to DNA...

journal_title：Journal of cell science

authors： Capasso H,Palermo C,Wan S,Rao H,John UP,O'Connell MJ,Walworth NC

更新日期：2002-12-01 00:00:00

abstract：:The mammalian inactive X chromosome (Xi) is a model for facultative heterochromatin. Increased DNA compaction for the Xi, and for facultative heterochromatin in general, has long been assumed based on recognition of a distinct Barr body using nucleic-acid staining. This conclusion has been challenged by a report revea...

journal_title：Journal of cell science

authors： Rego A,Sinclair PB,Tao W,Kireev I,Belmont AS

更新日期：2008-04-01 00:00:00

abstract：:Proteins of the Wiskott-Aldrich syndrome protein (WASP) family function as nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives the generation of branched actin filaments. Arp2/3-generated actin regulates diverse cellular processes, including the formation of lamellipodia and filopo...

journal_title：Journal of cell science

authors： Alekhina O,Burstein E,Billadeau DD

更新日期：2017-07-15 00:00:00

abstract：:A growing number of proteins originally found in endocytic structures of the plasma membrane appear to be able to traffic into the nucleus, but the cellular function of this translocation remains unclear. We have found that beta-arrestin2, which typically shows a cytoplasmic localization owing to constitutive nuclear ...

journal_title：Journal of cell science

authors： Neuhaus EM,Mashukova A,Barbour J,Wolters D,Hatt H

更新日期：2006-08-01 00:00:00

abstract：:Alix is a cytosolic protein in mammalian cells that was originally identified on the basis of its association with pro-apoptotic signaling. More recent evidence has established that Alix has a hand in regulating other cellular mechanisms, including endocytic membrane trafficking and cell adhesion. Although Alix appear...

journal_title：Journal of cell science

authors： Odorizzi G

更新日期：2006-08-01 00:00:00

abstract：:Rho GTPases and their downstream effectors regulate changes in the actin cytoskeleton that underlie cell motility and adhesion. They also participate, with RhoA, in the regulation of gene transcription by activating serum response factor (SRF)-mediated transcription from the serum response element (SRE). SRF-mediated ...

journal_title：Journal of cell science

authors： Xie Y,Tan EJ,Wee S,Manser E,Lim L,Koh CG

更新日期：2008-02-15 00:00:00

abstract：:The yeast nuclear scaffold has been shown to bind with high affinity to genomic sequences that permit autonomous DNA replication of plasmids (ARS elements). We describe here conditions for the isolation of a histone-free nuclear substructure, the nuclear scaffold, from Saccharomyces cerevisiae. We examine the protein ...

journal_title：Journal of cell science

authors： Cardenas ME,Laroche T,Gasser SM

更新日期：1990-07-01 00:00:00

abstract：:Integrins mediate cell adhesion and signal transduction at focal adhesions. Here we investigate the roles of integrin beta subunits in the regulation of actin cytoskeletal structure and the activities of Rho and Rac. The overexpression of beta3 integrin in Chinese hamster ovary cells enhances Rho activity and stress f...

journal_title：Journal of cell science

authors： Miao H,Li S,Hu YL,Yuan S,Zhao Y,Chen BP,Puzon-McLaughlin W,Tarui T,Shyy JY,Takada Y,Usami S,Chien S

更新日期：2002-05-15 00:00:00

abstract：:Endonuclease G is a mitochondrial protein implicated in DNA fragmentation during apoptosis in cell types ranging from fungi to mammals. Features of programmed cell death have been reported in a number of single-celled organisms, including the human trypanosomatid parasites Leishmania and Trypanosoma. However, the prot...

journal_title：Journal of cell science

authors： Gannavaram S,Vedvyas C,Debrabant A

更新日期：2008-01-01 00:00:00

abstract：:The full-length primary structure and expression profile of a novel unconventional myosin heavy chain, human myosin-IXb, is described. The primary structure of this myosin predicts a 229 kDa protein that together with its recently described rat homolog, myr 5, is the ninth class of myosins to be identified. In compari...

journal_title：Journal of cell science

authors： Wirth JA,Jensen KA,Post PL,Bement WM,Mooseker MS

更新日期：1996-03-01 00:00:00

abstract：:Monoclonal mouse hybridoma antibodies were obtained for secreted cellular fibronectin (cFn) from A8387 fibrosarcoma cells. One of them, 52-DH1 (DH), reacted exclusively with cFns but not with plasma Fns (pFns) in immunoblotting and solid-phase EIA. The DH antibody also recognized thermolysin cFn fragments and beta-gal...

journal_title：Journal of cell science

authors： Vartio T,Laitinen L,Närvänen O,Cutolo M,Thornell LE,Zardi L,Virtanen I

更新日期：1987-11-01 00:00:00

abstract：:alphaA-Crystallin (alphaA) is a molecular chaperone expressed preferentially in the lens. alphaA transcripts are first detected during the early stages of lens development and its synthesis continues as the lens grows throughout life. alphaA(-/-) mouse lenses are smaller than controls, and lens epithelial cells derive...

journal_title：Journal of cell science

authors： Xi JH,Bai F,Andley UP

更新日期：2003-03-15 00:00:00

abstract：:Cilia and flagella are conserved eukaryotic organelles important for motility and sensory. The RanGTPase, best known for nucleocytoplasmic transport functions, may also play a role in protein trafficking into the specialized flagellar/ciliary compartments, although the regulatory mechanisms controlling Ran activity at...

journal_title：Journal of cell science

authors： Brasseur A,Bayat S,Chua XL,Zhang Y,Zhou Q,Low BC,He CY

更新日期：2014-11-15 00:00:00

abstract：:Here, we identify a role for the matrilin-2 (Matn2) extracellular matrix protein in controlling the early stages of myogenic differentiation. We observed Matn2 deposition around proliferating, differentiating and fusing myoblasts in culture and during muscle regeneration in vivo. Silencing of Matn2 delayed the express...

journal_title：Journal of cell science

authors： Deák F,Mátés L,Korpos E,Zvara A,Szénási T,Kiricsi M,Mendler L,Keller-Pintér A,Ozsvári B,Juhász H,Sorokin L,Dux L,Mermod N,Puskás LG,Kiss I

更新日期：2014-08-01 00:00:00

abstract：:Maturation of nociceptive neurons depends on changes in transcription factors, ion channels and neuropeptides. Mature nociceptors initiate pain in part by drastically reducing the activation threshold via intracellular sensitization signaling. Whether sensitization signaling also changes during development and aging r...

journal_title：Journal of cell science

authors： Isensee J,Schild C,Schwede F,Hucho T

更新日期：2017-07-01 00:00:00

abstract：:Junctional adhesion molecules (JAMs) are members of an immunoglobulin subfamily expressed by leukocytes and platelets as well as by epithelial and endothelial cells, in which they localize to cell-cell contacts and are specifically enriched at tight junctions. The recent identification of extracellular ligands and int...

journal_title：Journal of cell science

authors： Ebnet K,Suzuki A,Ohno S,Vestweber D

更新日期：2004-01-01 00:00:00

abstract：:A key signaling event that is responsible for gradient sensing in eukaryotic cell chemotaxis is a phosphatidylinositol (PtdIns) lipid reaction system. The self-organization activity of this PtdIns lipid system induces an inherent polarity, even in the absence of an external chemoattractant gradient, by producing a loc...

journal_title：Journal of cell science

authors： Shibata T,Nishikawa M,Matsuoka S,Ueda M

更新日期：2012-11-01 00:00:00

abstract：:Actin-based myosin motors have a pivotal role in intracellular trafficking in eukaryotic cells. The parasitic protozoan organism Leishmania expresses a novel class of myosin, myosin XXI (Myo21), which is preferentially localized at the proximal region of the flagellum. However, its function in this organism remains la...

journal_title：Journal of cell science

authors： Katta SS,Tammana TV,Sahasrabuddhe AA,Bajpai VK,Gupta CM

更新日期：2010-06-15 00:00:00

abstract：:B chromosomes are centric chromosomal fragments present in thousands of eukaryotic genomes. Because most B chromosomes are non-essential, they can be lost without consequence. In order to persist, however, some B chromosomes can impose strong forms of intra-genomic conflict. An extreme case is the paternal sex ratio (...

journal_title：Journal of cell science

authors： Swim MM,Kaeding KE,Ferree PM

更新日期：2012-11-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival, neurite outgrowth and synaptic plasticity by activating the receptor tropomyosin receptor kinase B (TrkB, also known as NTRK2). TrkB has been shown to undergo recycling after BDNF stimulation. We have previously reported that full-l...

journal_title：Journal of cell science

authors： Sui WH,Huang SH,Wang J,Chen Q,Liu T,Chen ZY

更新日期：2015-03-15 00:00:00

abstract：:The cloned, SV40-immortalized mouse macrophage cell line, BAC1.2F5, resembles primary macrophages in its dependence on colony-stimulating factor-1 (CSF-1) for both viability and proliferation. Re-addition of CSF-1 stimulates rapid, transient behavioural changes in starved cells, which are rounded, with diffusely organ...

journal_title：Journal of cell science

authors： Boocock CA,Jones GE,Stanley ER,Pollard JW

更新日期：1989-07-01 00:00:00