Myosin Va mediates BDNF-induced postendocytic recycling of full-length TrkB and its translocation into dendritic spines.

abstract：:Failure to form proper synapses in mechanosensory hair cells, the sensory cells responsible for hearing and balance, leads to deafness and balance disorders. Ribbons are electron-dense structures that tether synaptic vesicles to the presynaptic zone of mechanosensory hair cells where they are juxtaposed with the post-...

journal_title：Journal of cell science

authors： Suli A,Pujol R,Cunningham DE,Hailey DW,Prendergast A,Rubel EW,Raible DW

更新日期：2016-06-01 00:00:00

abstract：:We have cloned and characterized a single copy C. reinhardtii gene containing an open reading frame of 333 nucleotides encoding a 12.7 kDa protein. The novel protein, DIP13, exhibits 60% identity with two mammalian proteins, human NA14 and an unnamed mouse protein. Homologous sequences are also present in several prot...

journal_title：Journal of cell science

authors： Pfannenschmid F,Wimmer VC,Rios RM,Geimer S,Kröckel U,Leiherer A,Haller K,Nemcová Y,Mages W

更新日期：2003-04-15 00:00:00

abstract：:Nuclear calcium signalling has been a controversial battlefield for many years and the question of how permeable the nuclear pore complexes (NPCs) are to Ca2+ has been the subject of a particularly hot dispute. Recent data from isolated nuclei suggest that the NPCs are open even after depletion of the Ca2+ store in th...

journal_title：Journal of cell science

authors： Gerasimenko O,Gerasimenko J

更新日期：2004-07-01 00:00:00

abstract：:In fission yeast, Mid1p, a major determinant for division plane position, defines a medial cortical compartment where it recruits myosin II at the onset of mitosis to initiate contractile ring assembly. How Mid1p is restricted to the medial cortex is unknown. We report here that in a pom1 polarity mutant, which displa...

journal_title：Journal of cell science

authors： Celton-Morizur S,Racine V,Sibarita JB,Paoletti A

更新日期：2006-11-15 00:00:00

abstract：:Basement membranes are complex extracellular matrices contributing to the regulation of growth, migration and differentiation of many cell types. However, little is known about the mechanisms regulating the deposition and assembly of basement membrane from its constituents. We have investigated the role of extracellul...

journal_title：Journal of cell science

authors： Austria MR,Couchman JR

更新日期：1991-06-01 00:00:00

abstract：:p97 (CDC-48 in Caenorhabditis elegans) is a ubiquitin-selective AAA (ATPases associated with diverse cellular activities) chaperone and its key function is to disassemble protein complexes. p97 functions in diverse cellular processes including endoplasmic reticulum (ER)-associated degradation, membrane fusion, and mei...

journal_title：Journal of cell science

authors： Sasagawa Y,Otani M,Higashitani N,Higashitani A,Sato K,Ogura T,Yamanaka K

更新日期：2009-10-15 00:00:00

abstract：:A complex network of interactions between the stroma, the extracellular matrix and the epithelium drives mammary gland development and function. Two main assumptions in chemical carcinogenesis of the mammary gland have been that carcinogens induce neoplasia by causing mutations in the DNA of the epithelial cells and t...

journal_title：Journal of cell science

authors： Maffini MV,Soto AM,Calabro JM,Ucci AA,Sonnenschein C

更新日期：2004-03-15 00:00:00

abstract：:Aberrant glycosylation of proteins and lipids is a common feature of many tumor cell types, and is often accompanied by alterations in membrane traffic and an anomalous localization of Golgi-resident proteins and glycans. These observations suggest that the Golgi complex is a key organelle for at least some of the fun...

journal_title：Journal of cell science

authors： Babiá T,Ayala I,Valderrama F,Mato E,Bosch M,Santarén JF,Renau-Piqueras J,Kok JW,Thomson TM,Egea G

更新日期：1999-02-01 00:00:00

abstract：:Onconase is an RNase with a very specific property because it is selectively toxic to transformed cells. This toxin is thought to recognize cell surface receptors, and the protection conferred by metabolic poisons against Onconase toxicity indicated that this RNase relies on endocytic uptake to kill cells. Nevertheles...

journal_title：Journal of cell science

authors： Rodríguez M,Torrent G,Bosch M,Rayne F,Dubremetz JF,Ribó M,Benito A,Vilanova M,Beaumelle B

更新日期：2007-04-15 00:00:00

abstract：:HT-29 cells selected by adaptation to 10(-5) M methotrexate (HT-29 MTX) are a homogeneous cell population producing high amounts of mucin. Intracellular mucins and proteoglycans were isolated from these cells by ultracentrifugation of cell lysates on a cesium bromide gradient and further separated by anion-exchange hi...

journal_title：Journal of cell science

authors： Huet G,Kim I,de Bolos C,Lo-Guidice JM,Moreau O,Hemon B,Richet C,Delannoy P,Real FX,Degand P

更新日期：1995-03-01 00:00:00

abstract：:Biglycan and decorin are small chondroitin/dermatan sulphate proteoglycans in the extracellular matrix of connective tissue that belong to the family of structurally related proteoglycans called small leucine-rich repeat proteins. We show for the first time that biglycan and decorin induce morphological and cytoskelet...

journal_title：Journal of cell science

authors： Tufvesson E,Westergren-Thorsson G

更新日期：2003-12-01 00:00:00

abstract：:BMP-dependent patterning in the Drosophila melanogaster wing imaginal disc serves as a paradigm to understand how morphogens specify cell fates. The observed profile of the transcriptional response to the graded signal of BMP relies upon two counter-active gradients of pMad and Brinker (Brk). This patterning model is ...

journal_title：Journal of cell science

authors： Ziv O,Finkelstein R,Suissa Y,Dinur T,Deshpande G,Gerlitz O

更新日期：2012-12-01 00:00:00

abstract：:Rab GTPases regulate various membrane trafficking pathways but the mechanisms by which GTPase-activating proteins recognise specific Rabs are not clear. Rab8 is involved in controlling several trafficking processes, including the trafficking of transferrin receptor from the early endosome to the recycling endosome. He...

journal_title：Journal of cell science

authors： Vaibhava V,Nagabhushana A,Chalasani ML,Sudhakar C,Kumari A,Swarup G

更新日期：2012-11-01 00:00:00

abstract：:Myosin VI is an actin-based retrograde motor protein that plays a crucial role in both endocytic and secretory membrane trafficking pathways. Myosin VI's targeting to and function in these intracellular pathways is mediated by a number of specific binding partners. In this paper we have identified a new myosin-VI-bind...

journal_title：Journal of cell science

authors： Chibalina MV,Seaman MN,Miller CC,Kendrick-Jones J,Buss F

更新日期：2007-12-15 00:00:00

abstract：:This project examines the transcellular membrane protein polarity of bovine aortic endothelial cell (BAEC) monolayers in vitro with respect to the roles that intercellular junctions (as defined by comparing confluent and subconfluent monolayers) and the submembranous cytoskeleton play in controlling this phenomenon. P...

journal_title：Journal of cell science

authors： Stolz DB,Bannish G,Jacobson BS

更新日期：1992-09-01 00:00:00

abstract：:Pin1/Ess1p is a highly conserved WW domain-containing peptidyl-prolyl isomerase (PPIase); its WW domain binds specifically to phospho-Ser/Thr-Pro sequences and its catalytic domain isomerizes phospho-Ser/Thr-Pro bonds. Pin1 PPIase activity can alter protein conformation in a phosphorylation-dependent manner and/or pro...

journal_title：Journal of cell science

authors： Huang HK,Forsburg SL,John UP,O'Connell MJ,Hunter T

更新日期：2001-10-01 00:00:00

abstract：:Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent; they share these properties with embryonic germ (EG) cells. Candidate ES and EG cell lines from the human blastocyst and embryonic gonad can differe...

journal_title：Journal of cell science

authors： Pera MF,Reubinoff B,Trounson A

更新日期：2000-01-01 00:00:00

abstract：:Here we report Drosophila Waharan (Wah), a 170-kD predominantly nuclear protein with two potential human homologues, as a newly identified regulator of endosomal trafficking. Wah is required for neuromuscular-junction development and muscle integrity. In muscles, knockdown of Wah caused novel accumulations of tightly ...

journal_title：Journal of cell science

authors： Lone M,Kungl T,Koper A,Bottenberg W,Kammerer R,Klein M,Sweeney ST,Auburn RP,O'Kane CJ,Prokop A

更新日期：2010-07-15 00:00:00

abstract：:The mammalian inactive X chromosome (Xi) is a model for facultative heterochromatin. Increased DNA compaction for the Xi, and for facultative heterochromatin in general, has long been assumed based on recognition of a distinct Barr body using nucleic-acid staining. This conclusion has been challenged by a report revea...

journal_title：Journal of cell science

authors： Rego A,Sinclair PB,Tao W,Kireev I,Belmont AS

更新日期：2008-04-01 00:00:00

abstract：:Human erythrocytes suspended in buffered isotonic saline were frozen to the temperature of liquid nitrogen at various cooling rates of 3, 140, 700, 1800, 3500, 8000 and 11 500 deg. C/min. The membrane ultrastructure in the frozen state and the extent of haemolysis after thawing were examined at each cooling rate. As t...

journal_title：Journal of cell science

authors： Fujikawa S

更新日期：1981-06-01 00:00:00

abstract：:In eukaryotes, mRNA export involves many evolutionarily conserved factors that carry the nascent transcript to the nuclear pore complex (NPC). The THO/TREX complex couples transcription to mRNA export and recruits the mRNA export receptor NXF1 for the transport of messenger ribonucleoprotein particles (mRNP) to the NP...

journal_title：Journal of cell science

authors： Umlauf D,Bonnet J,Waharte F,Fournier M,Stierle M,Fischer B,Brino L,Devys D,Tora L

更新日期：2013-06-15 00:00:00

abstract：:Identification of the cell surface glycoproteins is an essential requirement for elucidating the mechanisms that mediate intercellular adhesion and cell migration in gastrulating amphibian embryos. In our experiments the glycoproteins present at the surface of isolated cells at blastula and gastrula stages were labell...

journal_title：Journal of cell science

authors： Riou JF,Darribère T,Boucaut JC

更新日期：1986-06-01 00:00:00

abstract：:Splice variants of certain genes impact on genetic biodiversity in mammals. The tumor suppressor TP53 gene (encoding p53) plays an important role in the regulation of tumorigenesis in hepatocellular carcinoma (HCC). Δ40p53α is a naturally occurring p53 isoform that lacks the N-terminal transactivation domain, yet litt...

journal_title：Journal of cell science

authors： Ota A,Nakao H,Sawada Y,Karnan S,Wahiduzzaman M,Inoue T,Kobayashi Y,Yamamoto T,Ishii N,Ohashi T,Nakade Y,Sato K,Itoh K,Konishi H,Hosokawa Y,Yoneda M

更新日期：2017-02-01 00:00:00

abstract：:Actin-based myosin motors have a pivotal role in intracellular trafficking in eukaryotic cells. The parasitic protozoan organism Leishmania expresses a novel class of myosin, myosin XXI (Myo21), which is preferentially localized at the proximal region of the flagellum. However, its function in this organism remains la...

journal_title：Journal of cell science

authors： Katta SS,Tammana TV,Sahasrabuddhe AA,Bajpai VK,Gupta CM

更新日期：2010-06-15 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 (PARP1) is a nuclear enzyme that can trigger caspase-independent necrosis. Two main mechanisms for this have been proposed: one involving RIP1 and JNK kinases and mitochondrial permeability transition (MPT), the other involving calpain-mediated activation of Bax and mitochondrial release ...

journal_title：Journal of cell science

authors： Douglas DL,Baines CP

更新日期：2014-10-01 00:00:00

abstract：:Occludin plays an important role in maintaining tight junction barrier function in many types of epithelia. We previously reported that activation of transient receptor potential vanilloid subtype 1 (TRPV1) in rabbit submandibular gland promoted salivary secretion, partly by an increase in paracellular permeability. W...

journal_title：Journal of cell science

authors： Cong X,Zhang Y,Yang NY,Li J,Ding C,Ding QW,Su YC,Mei M,Guo XH,Wu LL,Yu GY

更新日期：2013-03-01 00:00:00

abstract：:Dynamins are a conserved family of proteins involved in membrane fusion and fission. Although mammalian dynamins are known to be involved in several membrane-trafficking events, the role of dynamin-1 in endocytosis is the best-characterised role of this protein family. Despite many similarities between endocytosis in ...

journal_title：Journal of cell science

authors： Smaczynska-de Rooij II,Allwood EG,Aghamohammadzadeh S,Hettema EH,Goldberg MW,Ayscough KR

更新日期：2010-10-15 00:00:00

abstract：:Protein kinase CK2, a vital, pleiotropic and highly conserved serine/threonine phosphotransferase is involved in transcription-directed signaling, gene control and cell cycle regulation and is suspected to play a role in global processes. Searching for these global roles, we analyzed the involvement of CK2 in gene exp...

journal_title：Journal of cell science

authors： Barz T,Ackermann K,Dubois G,Eils R,Pyerin W

更新日期：2003-04-15 00:00:00

abstract：:Cytoplasmic linker proteins (CLIPs) bind to microtubules and are proposed to link this cytoskeletal network to other intracellular structures. We are interested in CLIP-115, since this protein is enriched in neuronal dendrites and may operate in the control of brain-specific organelle translocations. Each CLIP monomer...

journal_title：Journal of cell science

authors： Hoogenraad CC,Akhmanova A,Grosveld F,De Zeeuw CI,Galjart N

更新日期：2000-06-01 00:00:00

abstract：:We have developed a procedure for sequential silver staining and in situ hybridization to analyze the relationship between the amount of rDNA present in nucleolar organizer regions, as estimated by in situ hybridization, and their level of expression, as estimated by the silver signal. For simplicity we used cells fro...

journal_title：Journal of cell science

authors： Zurita F,Jiménez R,Burgos M,de la Guardia RD

更新日期：1998-05-01 00:00:00