Cellular functions of WASP family proteins at a glance.

Abstract:

:Proteins of the Wiskott-Aldrich syndrome protein (WASP) family function as nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives the generation of branched actin filaments. Arp2/3-generated actin regulates diverse cellular processes, including the formation of lamellipodia and filopodia, endocytosis and/or phagocytosis at the plasma membrane, and the generation of cargo-laden vesicles from organelles including the Golgi, endoplasmic reticulum (ER) and the endo-lysosomal network. Recent studies have also identified roles for WASP family members in promoting actin dynamics at the centrosome, influencing nuclear shape and membrane remodeling events leading to the generation of autophagosomes. Interestingly, several WASP family members have also been observed in the nucleus where they directly influence gene expression by serving as molecular platforms for the assembly of epigenetic and transcriptional machinery. In this Cell Science at a Glance article and accompanying poster, we provide an update on the subcellular roles of WHAMM, JMY and WASH (also known as WASHC1), as well as their mechanisms of regulation and emerging functions within the cell.

journal_name

J Cell Sci

journal_title

Journal of cell science

authors

Alekhina O,Burstein E,Billadeau DD

doi

10.1242/jcs.199570

subject

Has Abstract

pub_date

2017-07-15 00:00:00

pages

2235-2241

issue

14

eissn

0021-9533

issn

1477-9137

pii

jcs.199570

journal_volume

130

pub_type

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