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Fecal metabolome of the Hadza hunter-gatherers: a host-microbiome integrative view.

Abstract：

:The recent characterization of the gut microbiome of traditional rural and foraging societies allowed us to appreciate the essential co-adaptive role of the microbiome in complementing our physiology, opening up significant questions on how the microbiota changes that have occurred in industrialized urban populations may have altered the microbiota-host co-metabolic network, contributing to the growing list of Western diseases. Here, we applied a targeted metabolomics approach to profile the fecal metabolome of the Hadza of Tanzania, one of the world's few remaining foraging populations, and compared them to the profiles of urban living Italians, as representative of people in the post-industrialized West. Data analysis shows that during the rainy season, when the diet is primarily plant-based, Hadza are characterized by a distinctive enrichment in hexoses, glycerophospholipids, sphingolipids, and acylcarnitines, while deplete in the most common natural amino acids and derivatives. Complementary to the documented unique metagenomic features of their gut microbiome, our findings on the Hadza metabolome lend support to the notion of an alternate microbiome configuration befitting of a nomadic forager lifestyle, which helps maintain metabolic homeostasis through an overall scarcity of inflammatory factors, which are instead highly represented in the Italian metabolome.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Turroni S,Fiori J,Rampelli S,Schnorr SL,Consolandi C,Barone M,Biagi E,Fanelli F,Mezzullo M,Crittenden AN,Henry AG,Brigidi P,Candela M

doi

10.1038/srep32826

subject

Has Abstract

pub_date

2016-09-14 00:00:00

pages

32826

issn

2045-2322

pii

srep32826

journal_volume

6

pub_type

杂志文章

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