Abstract：
:The gliotransmitter glutamate released from astrocytes can modulate neuronal firing by activating neuronal N-methyl-D-aspartic acid (NMDA) receptors. This enables astrocytic glutamate(AG) to be involved in neuronal physiological and pathological functions. Based on empirical results and classical neuron-glial "tripartite synapse" model, we propose a practical model to describe extracellular AG oscillation, in which the fluctuation of AG depends on the threshold of calcium concentration, and the effect of AG degradation is considered as well. We predict the seizure-like discharges under the dysfunction of AG degradation duration. Consistent with our prediction, the suppression of AG uptake by astrocytic transporters, which operates by modulating the AG degradation process, can account for the emergence of epilepsy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li J,Tang J,Ma J,Du M,Wang R,Wu Ydoi
10.1038/srep32343subject
Has Abstractpub_date
2016-08-30 00:00:00pages
32343issn
2045-2322pii
srep32343journal_volume
6pub_type
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