Abstract:
:Stable in vivo mapping and modulation of the same neurons and brain circuits over extended periods is critical to both neuroscience and medicine. Current electrical implants offer single-neuron spatiotemporal resolution but are limited by such factors as relative shear motion and chronic immune responses during long-term recording. To overcome these limitations, we developed a chronic in vivo recording and stimulation platform based on flexible mesh electronics, and we demonstrated stable multiplexed local field potentials and single-unit recordings in mouse brains for at least 8 months without probe repositioning. Properties of acquired signals suggest robust tracking of the same neurons over this period. This recording and stimulation platform allowed us to evoke stable single-neuron responses to chronic electrical stimulation and to carry out longitudinal studies of brain aging in freely behaving mice. Such advantages could open up future studies in mapping and modulating changes associated with learning, aging and neurodegenerative diseases.
journal_name
Nat Methodsjournal_title
Nature methodsauthors
Fu TM,Hong G,Zhou T,Schuhmann TG,Viveros RD,Lieber CMdoi
10.1038/nmeth.3969subject
Has Abstractpub_date
2016-10-01 00:00:00pages
875-82issue
10eissn
1548-7091issn
1548-7105pii
nmeth.3969journal_volume
13pub_type
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