Abstract：
:Recent work has demonstrated that environmental factors experienced by parents can affect their offspring across multiple generations, and that such transgenerational transmission can depend on the germline. Causal evidence for the involvement of germ cells is rare, however, and the underlying molecular mechanisms remain poorly understood. Further, studies often employ varying methods in experimental design and data interpretation. We provide a critical analysis of these issues and suggest possible solutions and guidelines for improving study design and generating reproducible and high-quality data.
journal_name
Nat Methodsjournal_title
Nature methodsauthors
Bohacek J,Mansuy IMdoi
10.1038/nmeth.4181subject
Has Abstractpub_date
2017-02-28 00:00:00pages
243-249issue
3eissn
1548-7091issn
1548-7105pii
nmeth.4181journal_volume
14pub_type
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