Abstract:
:Here we integrated multiphoton laser scanning microscopy and the registration of second harmonic generation images of collagen fibers to overcome difficulties in tracking stromal cell-matrix interactions for several days in live mice. We show that the matrix-modifying hormone relaxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating beta1-integrin activity, which is necessary for fiber remodeling by matrix metalloproteinases.
journal_name
Nat Methodsjournal_title
Nature methodsauthors
Perentes JY,McKee TD,Ley CD,Mathiew H,Dawson M,Padera TP,Munn LL,Jain RK,Boucher Ydoi
10.1038/nmeth.1295subject
Has Abstractpub_date
2009-02-01 00:00:00pages
143-5issue
2eissn
1548-7091issn
1548-7105pii
nmeth.1295journal_volume
6pub_type
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