Abstract：
:The complexities of tumor genomes are rapidly being uncovered, but how they are regulated into functional proteomes remains poorly understood. Standard proteomics workflows use databases of known proteins, but these databases do not capture the uniqueness of the cancer transcriptome, with its point mutations, unusual splice variants and gene fusions. Onco-proteogenomics integrates mass spectrometry-generated data with genomic information to identify tumor-specific peptides. Linking tumor-derived DNA, RNA and protein measurements into a central-dogma perspective has the potential to improve our understanding of cancer biology.
journal_name
Nat Methodsjournal_title
Nature methodsauthors
Alfaro JA,Sinha A,Kislinger T,Boutros PCdoi
10.1038/nmeth.3138subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1107-13issue
11eissn
1548-7091issn
1548-7105pii
nmeth.3138journal_volume
11pub_type
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