Requirement of IP3 receptor 3 (IP3R3) in nitric oxide induced cardiomyocyte differentiation of mouse embryonic stem cells.

abstract：:The RAI gene is also known as iASPP and PPP1R13L. Recent investigations have shown that the region encompassing RAI is important for the development of cancer in young and middle-aged persons. It has been speculated that the RAI product induces apoptosis by blocking NF-kappaB or inhibits apoptosis by blocking p53. Eit...

journal_title：Experimental cell research

authors： Laska MJ,Strandbygård D,Kjeldgaard A,Mains M,Corydon TJ,Memon AA,Sørensen BS,Vogel U,Jensen UB,Nexø BA

更新日期：2007-07-15 00:00:00

abstract：:Stem cells with the ability to differentiate in specialized cell types can be extracted from a wide array of adult tissues including skeletal muscle. Here we have analyzed a population of cells isolated from skeletal muscle on the basis of their poor adherence on uncoated or collagen-coated dishes that show multi-line...

journal_title：Experimental cell research

authors： Arsic N,Mamaeva D,Lamb NJ,Fernandez A

更新日期：2008-04-01 00:00:00

abstract：:β-Catenin signaling plays a pivotal role in the genesis of a variety of malignant tumors, but its role in breast cancer has not been fully elucidated. Here, we examined whether deregulation of β-catenin signaling is related to the aggressive characteristics of certain types of breast cancers. Analysis of cytokine leve...

journal_title：Experimental cell research

authors： Yasuhara R,Irié T,Suzuki K,Sawada T,Miwa N,Sasaki A,Tsunoda Y,Nakamura S,Mishima K

更新日期：2015-10-15 00:00:00

abstract：:Paromomycin is an aminocyclitol aminoglycoside antibiotic used for the treatment of leishmaniasis. In view of the central role of mitochondria in cellular energetics and metabolism, its effect on in vivo mitochondrial activities of Leishmania donovani promastigotes-the parasite flagellate form-was investigated. The ap...

journal_title：Experimental cell research

authors： Maarouf M,de Kouchkovsky Y,Brown S,Petit PX,Robert-Gero M

更新日期：1997-05-01 00:00:00

abstract：:The continuously decreasing willingness for liver donation aggravates treatment of end-stage liver diseases requiring organ transplantation as the only curative strategy. Cell therapy approaches using human hepatocytes or stem cell-derived hepatocyte-like cells may be a therapeutic option out of this dilemma. ABCB5-po...

journal_title：Experimental cell research

authors： Tietze L,Winkler S,Hempel M,Kluth MA,Tappenbeck N,Ganss C,Dooley S,Christ B

更新日期：2018-08-15 00:00:00

abstract：:Chondrocytes express CD44 as a primary receptor for the matrix macromolecule hyaluronan. Hyaluronan is responsible for the retention and organization of proteoglycan within cartilage, and hyaluronan-chondrocyte interactions are important for the assembly and maintenance of the cartilage matrix. Bovine articular chondr...

journal_title：Experimental cell research

authors： Aguiar DJ,Knudson W,Knudson CB

更新日期：1999-11-01 00:00:00

abstract：:It is known that freshly dissociated thyroid cell clusters form follicles in suspension culture. Thyroid epithelial cell lines, grown for many generations in vitro, fail to show colloid-containing lumina when cultured as monolayers. Several thyroid cell lines, some transformed, have been tested with respect to their a...

journal_title：Experimental cell research

authors： Nitsch L,Tacchetti C,Tramontano D,Ambesi-Impiombato FS

更新日期：1984-05-01 00:00:00

abstract：:The effects of the tubulin-binding drug colchicine on cultured neonate cardiac cell function were investigated. Application of low doses of colchicine (but not lumicolchicine) caused an early reversible increase in beating rate with a concomitant decrease in amplitude. Treatment of the cells with trypsin at a dose tha...

journal_title：Experimental cell research

authors： Lampidis TJ,Trevorrow KW,Rubin RW

更新日期：1986-06-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a major microvascular complication of diabetes that can lead to end-stage renal disease. Podocytes constitute the last barrier of glomerular filtration, whose damage are the direct cause of proteinuria. Dopamine receptors are involved in the regulation of diabetes-induced glomerular hyperf...

journal_title：Experimental cell research

authors： Shao X,Zhang X,Hu J,Gao T,Chen J,Xu C,Wei C

更新日期：2020-03-15 00:00:00

abstract：:Strategies for correct diagnosis, treatment evaluation and recurrence prediction are important for the prognosis and mortality rates among cancer patients. In spite of major improvements in clinical management, gastrointestinal stromal tumors (GISTs) can still be deadly due to metastasis and recurrences, which confirm...

journal_title：Experimental cell research

authors： Berglund E,Daré E,Branca RM,Akcakaya P,Fröbom R,Berggren PO,Lui WO,Larsson C,Zedenius J,Orre L,Lehtiö J,Kim J,Bränström R

更新日期：2015-08-01 00:00:00

abstract：:The rate-limiting step in melanogenesis is catalyzed by tyrosinase, a multifunctional enzyme encoded by the albino locus. We have previously reported that depletion of protein kinase C by long-term treatment of B16 mouse melanoma cells with phorbol dibutyrate (PDBu) prevented cell density-dependent melanogenesis. This...

journal_title：Experimental cell research

authors： Mahalingam H,Watanabe A,Tachibana M,Niles RM

更新日期：1997-11-25 00:00:00

abstract：:In human and non-human primates, migratory trophoblasts penetrate the uterine epithelium, invade the endometrium, enter the uterine vasculature, and migrate within the arteries. The mechanisms that regulate this directional migration are unknown. We have used early gestation macaque trophoblasts to test the hypothesis...

journal_title：Experimental cell research

authors： Thirkill TL,Lowe K,Vedagiri H,Blankenship TN,Barakat AI,Douglas GC

更新日期：2005-05-01 00:00:00

abstract：:Changes in the expression pattern of DNA polymerase beta gene during rat lung, brain, and testis development have been investigated. A decrease in the level of beta-pol mRNA was observed during postnatal development of lung and brain. By contrast, an almost 20-fold increase in the level of beta-pol mRNA was observed d...

journal_title：Experimental cell research

authors： Nowak R,Woszczynski M,Siedlecki JA

更新日期：1990-11-01 00:00:00

abstract：:Metastatic progression is a major cause of mortality in cervical cancers, but factors regulating migratory and pre-metastatic cell populations remain poorly understood. Here, we sought to assess whether a SUV39H1-low chromatin state promotes migratory cell populations in cervical cancers, using meta-analysis of data f...

journal_title：Experimental cell research

authors： Rodrigues C,Pattabiraman C,Vijaykumar A,Arora R,Narayana SM,Kumar RV,Notani D,Varga-Weisz P,Krishna S

更新日期：2019-05-15 00:00:00

abstract：:Screening for microbial metabolites that induce transcriptional activation of the SV40 promoter resulted in the identification of two known compounds, FR901228 and trichostatin A (TSA). FR901228 is a potent antitumor drug that is currently under clinical investigation. TSA is a specific inhibitor of histone deacetylas...

journal_title：Experimental cell research

authors： Nakajima H,Kim YB,Terano H,Yoshida M,Horinouchi S

更新日期：1998-05-25 00:00:00

abstract：:Recent studies have demonstrated a central role for the exchange protein activated by cAMP (Epac) in the inhibition of Fcgamma-receptor-mediated phagocytosis and bacterial killing by prostaglandin E(2) (PGE(2)) in macrophages. However, the subcellular localization of Epac, and its primary target Rap1, has yet to be de...

journal_title：Experimental cell research

authors： Brock TG,Serezani CH,Carstens JK,Peters-Golden M,Aronoff DM

更新日期：2008-01-15 00:00:00

abstract：:Mechanisms involved in establishing the organization and numbers of fibres in a muscle are not completely understood. During Drosophila indirect flight muscle (IFM) formation, muscle growth is achieved by both incorporating hundreds of nuclei, and hypertrophy. As a result, IFMs provide a good model with which to under...

journal_title：Experimental cell research

authors： Rai M,Nongthomba U

更新日期：2013-10-15 00:00:00

abstract：:To determine which endocytic compartments are sensitive to sucrose-induced osmotic swelling, CHO and Vero cells were cultured for 1-3 days in media containing 0.03 to 0.05 M sucrose. (Sucrose is internalized but not digested by these cells.) To immunolocalize late endocytic compartments, cells were fixed with formalde...

journal_title：Experimental cell research

authors： DeCourcy K,Storrie B

更新日期：1991-01-01 00:00:00

abstract：:The activation of cdc2/cyclin B is the trigger for entry into mitosis. The mechanism of cdc2/cyclin B activation is complex, but the final step is the dephosphorylation of the Thr14 and Tyr15 residues on the cdc2 subunit, catalyzed by a member of the Cdc25 family of phosphatases. Cdc2/cyclin B1 accumulates at the cent...

journal_title：Experimental cell research

authors： De Souza CP,Ellem KA,Gabrielli BG

更新日期：2000-05-25 00:00:00

abstract：:The importance of the cytoskeleton in protein synthesis was studied in differentiating L6 rat myoblasts. Soluble and cytoskeletal fractions obtained after gentle, non-ionic detergent lysis of myoblasts and myotubes were analysed for the presence of ribosomes and mRNPs. Polysomal mRNPs were predominantly associated wit...

journal_title：Experimental cell research

authors： Bagchi T,Larson DE,Sells BH

更新日期：1987-01-01 00:00:00

abstract：:HIV-associated nephropathy (HIVAN) is characterized by heavy proteinuria, rapidly progressive renal failure, and distinct morphological features in the kidney. HIV-induced epithelial-mesenchymal transition (EMT) is critically important for the progression of kidney injury. In this study, we tested the role of hedgehog...

journal_title：Experimental cell research

authors： Lan X,Wen H,Cheng K,Plagov A,Marashi Shoshtari SS,Malhotra A,Singhal PC

更新日期：2017-03-15 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold tremendous potential for the development of new regenerative medicine therapies and the study of molecular mechanisms of pluripotency and development. However, reactivation of c-Myc, which results in tumor formation in chimeric mice, is a major roadblock in the translation o...

journal_title：Experimental cell research

authors： Habib O,Habib G,Choi HW,Hong KS,Do JT,Moon SH,Chung HM

更新日期：2013-12-10 00:00:00

abstract：:Signalling through the fibroblast growth factor family (FGF) of ligands is essential for normal mammalian embryonic development. At a cellular level, many details of the molecular basis of the signal transduction process have been uncovered, but our knowledge of the identity of the downstream effectors of the FGF sign...

journal_title：Experimental cell research

authors： Tateossian H,Powles N,Dickinson R,Ficker M,Maconochie M

更新日期：2004-01-01 00:00:00

abstract：:Recent studies report mitochondrial carrier homolog 2 (MTCH2) as a novel and uncharacterized protein that acts as a receptor-like protein for the truncated BH3-interacting domain death agonist (tBID) protein in the outer membrane of mitochondria. These studies, using mouse embryonic stem cells and fibroblasts as well ...

journal_title：Experimental cell research

authors： Robinson AJ,Kunji ER,Gross A

更新日期：2012-07-01 00:00:00

abstract：:Integrin beta 4 subunit is present in association with alpha 6 chain on both normal and transformed epithelial cells. Recently alpha 6 beta 4 heterodimer was found on the endothelium of medium-sized blood vessels and on immature thymocytes. In this report we show, by Northern blotting, indirect immunofluorescence, imm...

journal_title：Experimental cell research

authors： Scardigli R,Soddu S,Falcioni R,Crescenzi M,Cimino L,Sacchi A

更新日期：1996-09-15 00:00:00

abstract：:LANA2 is a latent protein detected in Kaposi's sarcoma-associated herpesvirus (KSHV)-infected B cells that inhibits p53-dependent transcriptional transactivation and apoptosis and PKR-dependent apoptosis, suggesting an important role in the transforming activity of the virus. It has been reported that LANA2 localizes ...

journal_title：Experimental cell research

authors： Muñoz-Fontela C,Collado M,Rodriguez E,García MA,Alvarez-Barrientos A,Arroyo J,Nombela C,Rivas C

更新日期：2005-11-15 00:00:00

abstract：:Up-regulation of intercellular adhesion molecule-1 (ICAM-1) and its soluble form are involved in the chronic inflammation. For the first time, we demonstrated that resveratrol (RE), a natural polyphenol with antioxidant and anti-inflammatory properties, reduces the increase of expression and release of ICAM-1, due to ...

journal_title：Experimental cell research

authors： Domazetovic V,Bonanomi AG,Stio M,Vincenzini MT,Iantomasi T

更新日期：2019-09-15 00:00:00

abstract：:Endothelial cell-selective adhesion molecule (ESAM) is an immunoglobulin-like transmembrane protein associated with endothelial tight junctions (TJ). Based on a yeast two-hybrid screen, we have identified the membrane-associated guanylate kinase protein MAGI-1 as an intracellular binding partner of ESAM. MAGI-1 is a m...

journal_title：Experimental cell research

authors： Wegmann F,Ebnet K,Du Pasquier L,Vestweber D,Butz S

更新日期：2004-10-15 00:00:00

abstract：:Nogo-B/ASY has been characterized as a novel human apoptosis-inducing protein without any known apoptosis-related motifs. However, the validity of Nogo-B/ASY as a physiological apoptotic protein was recently questioned. In present research, we demonstrate that ASY overexpression contributes to ER stress and induces ap...

journal_title：Experimental cell research

authors： Kuang E,Wan Q,Li X,Xu H,Zou T,Qi Y

更新日期：2006-07-01 00:00:00

abstract：:Renal expression of the aldolase B isoenzyme and transcription factors previously shown to regulate the aldolase B gene promoter in the liver were analyzed in whole kidney, microdissected tubules, and the two PKSV-PCT and PKSV-PR proximal tubule cell lines derived from transgenic mice. Aldolase B gene expression appea...

journal_title：Experimental cell research

authors： Vallet V,Bens M,Antoine B,Levrat F,Miquerol L,Kahn A,Vandewalle A

更新日期：1995-02-01 00:00:00