当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Controlled release of drug and better bioavailability using poly(lactic acid-co-glycolic acid) nanoparticles.

Controlled release of drug and better bioavailability using poly(lactic acid-co-glycolic acid) nanoparticles.

Abstract：

:Tamoxifen (Tmx) embedded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGA-Tmx) is prepared to evaluate its better DNA cleavage potential, cytotoxicity using Dalton's lymphoma ascite (DLA) cells and MDA-MB231 breast cancer cells. PLGA-Tmx nanoparticles are prepared through emulsified nanoprecipitation technique with varying dimension of 17-30nm by changing the concentrations of polymer, emulsifier and drug. Nanoparticles dimension are measured through electron and atomic force microscopy. Interactions between tamoxifen and PLGA are verified through spectroscopic and calorimetric methods. PLGA-Tmx shows excellent DNA cleavage potential as compared to pure Tmx raising better bioavailability. In vitro cytotoxicity studies indicate that PLGA-Tmx reduces DLA cells viability up to ∼38% against ∼15% in pure Tmx. Hoechst stain is used to detect apoptotic DLA cells through fluorescence imaging of nuclear fragmentation and condensation exhibiting significant increase of apoptosis (70%) in PLGA-Tmx vis-à-vis pure drug (58%). Enhanced DNA cleavage potential, nuclear fragmentation and condensation in apoptotic cells confirm greater bioavailability of PLGA-Tmx as compared to pure Tmx in terms of receptor mediated endocytosis. Hence, the sustained release kinetics of PLGA-Tmx nanoparticles shows much better anticancer efficacy through enhanced DNA cleavage potential and nuclear fragmentation and, thereby, reveal a novel vehicle for the treatment of cancer.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Pandey SK,Patel DK,Maurya AK,Thakur R,Mishra DP,Vinayak M,Haldar C,Maiti P

doi

10.1016/j.ijbiomac.2016.04.065

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

99-110

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)30373-7

journal_volume

89

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Levan promotes antiproliferative and pro-apoptotic effects in MCF-7 breast cancer cells mediated by oxidative stress.

    abstract：:Exopolysaccharides are high-valued bio-products produced by various microbial species and have been described to possess biological response modifying activities. These bio-products have been effective as therapeutic agents in various human disease conditions. The objective of this study was to examine the effects of ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.04.035

    authors： Queiroz EAIF,Fortes ZB,da Cunha MAA,Sarilmiser HK,Barbosa Dekker AM,Öner ET,Dekker RFH,Khaper N

    更新日期：2017-09-01 00:00:00

  • Effect of diameter of poly(lactic acid) fiber on the physical properties of poly(ɛ-caprolactone).

    abstract：:Biodegradable polymer composites based on poly(ɛ-caprolactone) (PCL) and poly(lactic acid) (PLA) fibers with diameters of 18, 26, 180 μm were prepared by melt compounding. The PLA fiber content in the composites was constant at 20% by weight. The effects of fibers with different diameters on the physical properties an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.01.059

    authors： Ju D,Han L,Guo Z,Bian J,Li F,Chen S,Dong L

    更新日期：2015-05-01 00:00:00

  • Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes.

    abstract：:To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water v...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.12.004

    authors： Yoo CR,Yeo IS,Park KE,Park JH,Lee SJ,Park WH,Min BM

    更新日期：2008-05-01 00:00:00

  • Fabrication of cationic nanostructures from short self-assembling amphiphilic mixed α/β-pentapeptide: Potential candidates for drug delivery, gene delivery, and antimicrobial applications.

    abstract：:The present article describes designing and fabrication of nanostructures from a mixed α/β-pentapeptide, Lys-βAla-βAla-Lys-βAla, which majorly contains non-natural β-alanine residues in the backbone with two α-lysine residues at 1- and 4-positions. The amphiphilic pentapeptide showed the ability to self-assemble into ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.01.079

    authors： Goel R,Garg C,Gautam HK,Sharma AK,Kumar P,Gupta A

    更新日期：2018-05-01 00:00:00

  • Encapsulation of β-carotene in oleogel-in-water Pickering emulsion with improved stability and bioaccessibility.

    abstract：:β-carotene (BC) is beneficial for human health. However, the low oxidative stability and bioavailability of hydrophobic BC limit its utilization as supplements in functional foods and pharmaceutical products. Herein a conventional oil-in-water Pickering emulsion (OPEs-1) and an oleogel-in-water Pickering emulsion (OPE...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.227

    authors： Qi W,Zhang Z,Wu T

    更新日期：2020-12-01 00:00:00

  • Ca2+-induced stabilization of the nucleoside 2'- deoxyribosyltransferase from Lactobacillus hilgardii ZJS01: Characteristics and application in nucleosides synthesis.

    abstract：:A novel nucleoside 2'-deoxyribosyltransferase (LhNDT) from Lactobacillus hilgardii ZJS01 was cloned and expressed in Escherichia coli BL21 (DE3). The amino acid sequence of LhNDT displayed the highest identity of 26% to other reported NDTs. LhNDT was a monomer as revealed by gel filtration chromatography with or witho...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.08.104

    authors： Zhang J,Zhou Y,Liu K,Chu J,Zhang Y,He B

    更新日期：2018-01-01 00:00:00

  • Chemical composition of Cyclocarya paliurus polysaccharide and inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophage.

    abstract：:This study was designed to study the chemical composition of Cyclocarya paliurus polysaccharide and inflammatory effects in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage. A new elution (0.3% NaCl aqueous solution) of Cyclocarya paliurus polysaccharide (CPP-3) was characterized by different methods such as fo...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.055

    authors： Xiong L,Ouyang KH,Jiang Y,Yang ZW,Hu WB,Chen H,Wang N,Liu X,Wang WJ

    更新日期：2018-02-01 00:00:00

  • The development of advanced cellulosic fibres.

    abstract：:For the majority of the last century, commercial routes to regenerated cellulose fibres have coped with the difficulties of making a good cellulose solution by using an easy to dissolve derivative (e.g. xanthate in the case of viscose rayon) or complex (e.g. cuprammonium rayon). For the purposes of this paper, advance...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/0141-8130(96)81836-8

    authors： Woodings CR

    更新日期：1995-12-01 00:00:00

  • Preparation and antibacterial properties of ε-polylysine-containing gelatin/chitosan nanofiber films.

    abstract：:An effective antibacterial nanofiber film was prepared through the incorporation of ε-polylysine (ε-PL) into gelatin/chitosan-based polymers. All nanofiber films had uniformly disordered fibrous structure with good diameter distribution. The weight ratio of the gelatin/chitosan/ε-PL (G/C/P) influenced the solution pro...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.08.152

    authors： Liu F,Liu Y,Sun Z,Wang D,Wu H,Du L,Wang D

    更新日期：2020-12-01 00:00:00

  • Hydrogen-Deuterium exchange kinetics in β-lactoglobulin (-)-epicatechin complexes studied by FTIR spectroscopy.

    abstract：:Hydrogen-Deuterium exchange kinetics of β-lactoglobulin and β-lactoglobulin (-)-epicatechin solutions has been investigated through the analysis of the amide I absorption band at 1650cm-1 in the FTIR spectrum. H-D substitution in NH amides and residues of the protein results in a slight red-shift and in intensity chan...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.06.028

    authors： Caporaletti F,Carbonaro M,Maselli P,Nucara A

    更新日期：2017-11-01 00:00:00

  • Biocompatible, drug-loaded anti-adhesion barrier using visible-light curable furfuryl gelatin derivative.

    abstract：:Recently, many of studies have been attempted to determine how to decrease adhesion. To effectively prevent adhesion, decrease in unnecessary surgical procedures, prevention of contact with other tissue, and drug treatment for inflammation are required. However, current anti-adhesion materials have disadvantages. To s...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.180

    authors： Kim EH,Kim JW,Han GD,Noh SH,Choi JH,Choi C,Kim MK,Nah JW,Kim TY,Ito Y,Son TI

    更新日期：2018-12-01 00:00:00

  • Starch-g-Poly-(N, N-dimethyl acrylamide-co-acrylic acid): an efficient Cr (VI) ion binder.

    abstract：:Synthesis of Starch-g-(Poly N, N-dimethylacrylamide-co-acrylic acid) was carried out by solution polymerization technique using potassium perdisulfate (K(2)S(2)O(8)) as the initiator. The graft copolymer was characterized by measuring molecular weight, using size exclusion chromatography (SEC), FTIR spectroscopy and X...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.09.003

    authors： Kolya H,Roy A,Tripathy T

    更新日期：2015-01-01 00:00:00

  • Evidence of two oxidation states of copper during aggregation of hen egg white lysozyme (HEWL).

    abstract：:In vitro fibrillation of hen egg white lysozyme (HEWL) causes complete reduction of Cu(II) to Cu(I) at pH 7. Here in the present article, we have shown the presence of both Cu(II) and Cu(I) at pH 11 during fibrillation of HEWL using electron paramagnetic resonance and Raman spectroscopy. Our results suggest the existe...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.02.014

    authors： Ghosh S,Pandey NK,Bhattacharya S,Roy A,Nagy NV,Dasgupta S

    更新日期：2015-05-01 00:00:00

  • A novel quaternized chitosan-melamine-glutaraldehyde resin for the removal of nitrate and phosphate anions.

    abstract：:A terpolymer of chitosan-melamine-glutaraldehyde was prepared for the first time and it was quaternized with glycidyl trimethyl ammonium chloride (GTMAC). The quaternized chitosan-melamine-glutaraldehyde resin (QCMGR) was found to be effective for the removal of nitrate and phosphate oxyanions. The resin was character...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.11.036

    authors： Sowmya A,Meenakshi S

    更新日期：2014-03-01 00:00:00

  • Characterization of chitosan-magnesium aluminum silicate nanocomposite films for buccal delivery of nicotine.

    abstract：:The objective of this study was to prepare and characterize chitosan-magnesium aluminum silicate (CS-MAS) nanocomposite films as a buccal delivery system for nicotine (NCT). The effects of the CS-MAS ratio on the physicochemical properties, release and permeation, as well as on the mucoadhesive properties, were invest...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.12.043

    authors： Pongjanyakul T,Khunawattanakul W,Strachan CJ,Gordon KC,Puttipipatkhachorn S,Rades T

    更新日期：2013-04-01 00:00:00

  • Protection of groundnut plants from rust disease by application of glucan isolated from a biocontrol agent Acremonium obclavatum.

    abstract：:Prior treatment of groundnut leaves with glucan isolated from a biocontrol agent, Acremonium obclavatum, protected against the rust disease. Glucan treated leaves showed increased levels of chitinase and β-1,3-glucanase in the apoplastic fluid. An increase in endogenous levels of salicylic acid also was observed in tr...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.04.190

    authors： Sathiyabama M,Balasubramanian R

    更新日期：2018-09-01 00:00:00

  • The protective effects of walnut green husk polysaccharide on liver injury, vascular endothelial dysfunction and disorder of gut microbiota in high fructose-induced mice.

    abstract：:This study aimed to investigate the protective effects of walnut green husk polysaccharide (WGHP) on liver injury, vascular endothelial dysfunction and disorder of gut microbiota in mice induced by high fructose (HF) diet. The chemical analysis results show that the walnut green husk polysaccharide is a low molecular ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.055

    authors： Wang G,Zhang Y,Zhang R,Pan J,Qi D,Wang J,Yang X

    更新日期：2020-11-01 00:00:00

  • Mechanism of solvent induced thermal stabilization of papain.

    abstract：:In the present study an attempt is made to elucidate the effects of various cosolvents, such as sorbitol, sucrose, xylose and glycerol, on papain. The stabilizing effects of these cosolvents on the structure and function of papain is determined by the activity measurements, fluorescence spectroscopy and differential s...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.05.009

    authors： Sathish HA,Kumar PR,Prakash V

    更新日期：2007-10-01 00:00:00

  • Physical properties and structure of aquatic silk fiber from Stenopsyche marmorata.

    abstract：:To study the properties and structure of aquatic silk, nest-spinning hydropsychid caddisfly (Stenopsyche marmorata) larva were collected from a Japanese river and the silk glands were removed from the larva by dissecting and dried on the glass plate at room temperature. The silk fibers were obtained by removing fibrou...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2009.10.003

    authors： Tsukada M,Khan MM,Inoue E,Kimura G,Hun JY,Mishima M,Hirabayashi K

    更新日期：2010-01-01 00:00:00

  • Structural characterization and immunostimulatory activity of a glucan from Cyclina sinensis.

    abstract：:Cyclina sinensis is an edible clam widely distributed along the coastal waters of Asia. In the present study, a polysaccharide (CSP-1) isolated from C. sinensis was purified by a DEAE-Sepharose Fast Flow column, and it had an average molecular weight of 3.8 × 105 Da and a prevalent component monosaccharide of Glc. The...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.020

    authors： Gong Y,Cao C,Ai C,Wen C,Wang L,Zhao J,Han Y,Song S,Xiao H

    更新日期：2020-10-15 00:00:00

  • Effects of the ultra-high pressure on structure and α-glucosidase inhibition of polysaccharide from Astragalus.

    abstract：:A novel homogeneous polysaccharide fraction (APS) was extracted from Astragalus by hot water and purified by Sephadex G-100 and G-75 column. Its molecular weight was 693kDa. APS and APS with ultra-high pressure treatment exhibited significant inhibitory abilities on a-glucosidase, inhibition rate from high to low in o...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.03.024

    authors： Zhu ZY,Luo Y,Dong GL,Ren YY,Chen LJ,Guo MZ,Wang XT,Yang XY,Zhang Y

    更新日期：2016-06-01 00:00:00

  • Development of enzymatically-active bacterial cellulose membranes through stable immobilization of an engineered β-galactosidase.

    abstract：:Enzymatically-active bacterial cellulose (BC) was prepared by non-covalent immobilization of a hybrid enzyme composed by a β-galactosidase from Thermotoga maritima (TmLac) and a carbohydrate binding module (CBM2) from Pyrococcus furiosus. TmLac-CBM2 protein was bound to BC, with higher affinity at pH 6.5 than at pH 8....

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.04.081

    authors： Estevinho BN,Samaniego N,Talens-Perales D,Fabra MJ,López-Rubio A,Polaina J,Marín-Navarro J

    更新日期：2018-08-01 00:00:00

  • Phenothiazine-chitosan based eco-adsorbents: A special design for mercury removal and fast naked eye detection.

    abstract：:The aim of the paper was to investigate the ability of an eco-friendly luminescent xerogel prepared by chitosan crosslinking with a phenothiazine luminogen to detect and remove heavy metals. Its ability to give a divergent morphological and optical response towards fifteen environmental relevant metals was investigate...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.232

    authors： Bejan A,Doroftei F,Cheng X,Marin L

    更新日期：2020-11-01 00:00:00

  • Preparation of low digestible and viscoelastic tigernut (Cyperus esculentus) starch by Bacillus acidopullulyticus pullulanase.

    abstract：:Tigernut starch is an underutilized food resource. In this study, pullulanase (PUL) hydrolysis was used to change its physiochemical properties for different food applications. The content of low digestible fractions, resistant starch and slow digestible starch, in PUL modified tigernut starch significantly increased ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.04.068

    authors： Li X,Fu J,Wang Y,Ma F,Li D

    更新日期：2017-09-01 00:00:00

  • Complexation of rice starch/flour and maize oil through heat moisture treatment: Structural, in vitro digestion and physicochemical properties.

    abstract：:This study investigated structural, in vitro digestion and physicochemical properties of normal rice starch (NRS)/flour (NRF) complexed with maize oil (MO) through heat-moisture treatment (HMT). The NRS-/NRF-MO complex displayed an increased pasting temperature and a decreased peak viscosity. After HMT, less ordered M...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.01.105

    authors： Chen X,He X,Fu X,Zhang B,Huang Q

    更新日期：2017-05-01 00:00:00

  • Structural and thermodynamic studies of binding saturated fatty acids to bovine β-lactoglobulin.

    abstract：:Lactoglobulin is a globular milk protein for which physiological function has not been clarified. Due to its binding properties lactoglobulin might serve as a carrier for bioactive molecules. Binding of 12-, 14-, 16- and 18-carbon saturated fatty acids to bovine β-lactoglobulin has been characterised by isothermal tit...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.03.002

    authors： Loch JI,Polit A,Bonarek P,Olszewska D,Kurpiewska K,Dziedzicka-Wasylewska M,Lewiński K

    更新日期：2012-05-01 00:00:00

  • Effect of sulfate group on sulfated polysaccharides-induced improvement of metabolic syndrome and gut microbiota dysbiosis in high fat diet-fed mice.

    abstract：:Sulfated polysaccharides were shown to benefit metabolic syndrome (MS) and gut microbiota, but the contribution of sulfate group remains unclear. In this study, sulfated polysaccharides from pacific abalone (AGSP) and its desulfated product (D-AGSP) were prepared, and the contribution of sulfate group was analyzed via...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.08.010

    authors： Wu S,Liu Y,Jiang P,Xu Y,Zheng W,Song S,Ai C

    更新日期：2020-12-01 00:00:00

  • Synthesis of phosphorylated chitosan by novel method and its characterization.

    abstract：:Chitosan a natural based polymer is non-toxic, biocompatible and biodegradable. Chemical modification of chitosan to generate new bifunctional materials and finally would bring new properties depending on the nature of the group introduced. In our present study, we prepared phosphorylated chitosan (P-chitosan) by usin...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.12.011

    authors： Jayakumar R,Nagahama H,Furuike T,Tamura H

    更新日期：2008-05-01 00:00:00

  • Montmorillonite/graphene oxide/chitosan composite: Synthesis, characterization and properties.

    abstract：:The present work reports the successful preparation, thermal and mechanical characterization of high performance films of Na(+) montmorillonite (MMT)/graphene oxide (GO)/chitosan (CS) composite using simple solution mixing evaporation method. The formations of films were verified by Fourier transform infrared (FT-IR) ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.05.055

    authors： Yadav M,Ahmad S

    更新日期：2015-08-01 00:00:00

  • Viscosity of alpha-crystallin solutions.

    abstract：:Accommodation in the mammalian lens requires flexure of lens fibres and some redistribution of their contents involving limited viscous flow. Shear-dependent viscosity of bovine alpha-crystallin solutions was determined with the Contraves Low-Shear Rheometer between 4.4 and 347 mg ml(-1), and at 15.5, 25, 30, and 37 d...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(02)00018-1

    authors： Tiffany JM,Koretz JF

    更新日期：2002-06-18 00:00:00