当前位置： SCI文献检索 > JOURNAL OF BIOMECHANICS期刊下所有文献 > Bi-linear mechanical property determination of acellular human patellar tendon grafts for use in anterior cruciate ligament replacement.

Bi-linear mechanical property determination of acellular human patellar tendon grafts for use in anterior cruciate ligament replacement.

Abstract：

:Anterior cruciate ligament rupture is rising in its prevalence amongst the young and those with physically active lifestyles. Acellular human patellar tendon (PT) grafts offer a promising restoration solution, returning knee joint stability and overcoming some of the current disadvantages of autologous or allogeneic grafts. However, it is necessary to ensure that the decellularisation bio-processes involved do not cause structural changes in the microstructure of the tendon tissue that may adversely affect the mechanical properties, particularly with respect to the physiological range of loading. Sixteen cadaveric human PT grafts were sourced and processed from eight donors, with full ethical approval and consent for use in research. Eight specimens were allocated for decellularisation, while the remaining eight contralateral specimens were used as native controls. Testing consisted of 12 preconditioning cycles followed by uniaxial extension until failure occurred. Stress-strain data was then fitted to a bi-linear model using least squares regression by a custom-written Matlab script. The elastic moduli for the toe region and linear region of each specimen were determined, in addition to the transition point co-ordinates and strain energy density for increasing strain. No significant differences were found between groups for all of the parameters investigated. Hence, the shape and magnitude of the stress-strain profile was found to be the same for both groups throughout loading. The results of this study indicated that decellularisation appeared to have no effect on the material properties of human PT grafts under quasistatic conditions. Therefore, acellular human PT grafts can offer a viable additional solution for ACL replacement compared to current autologous and allogeneic treatment options.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Herbert A,Brown C,Rooney P,Kearney J,Ingham E,Fisher J

doi

10.1016/j.jbiomech.2016.03.041

subject

Has Abstract

pub_date

2016-06-14 00:00:00

pages

1607-1612

issue

9

eissn

0021-9290

issn

1873-2380

pii

S0021-9290(16)30379-7

journal_volume

49

pub_type

杂志文章

相关文献

JOURNAL OF BIOMECHANICS文献大全
  • Walking at the preferred stride frequency maximizes local dynamic stability of knee motion.

    abstract：:Healthy humans display a preference for walking at a stride frequency dependent on the inertial properties of their legs. Walking at preferred stride frequency (PSF) is predicted to maximize local dynamic stability, whereby sensitivity to intrinsic perturbations arising from natural variability inherent in biological ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2013.10.012

    authors： Russell DM,Haworth JL

    更新日期：2014-01-03 00:00:00

  • Hip extension, knee flexion paradox: a new mechanism for non-contact ACL injury.

    abstract：:Considering that an athlete performs at-risk sports activities countless times throughout the course of his or her career prior to the instance of anterior cruciate ligament (ACL) injury, one may conclude that non-contact ACL injury is a rare event. Nevertheless, the overall number of non-contact ACL injuries, both in...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2010.11.013

    authors： Hashemi J,Breighner R,Chandrashekar N,Hardy DM,Chaudhari AM,Shultz SJ,Slauterbeck JR,Beynnon BD

    更新日期：2011-02-24 00:00:00

  • Mechanical properties vary for different regions of the finger extensor apparatus.

    abstract：:The extensor apparatus, an aponeurosis that covers the dorsal side of each finger, transmits force from a number of musculotendons to the phalanges. Multiple tendons integrate directly into the structure at different sites and the extensor apparatus attaches to the phalanges at multiple points. Thus, prediction of the...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2014.06.035

    authors： Qian K,Traylor K,Lee SW,Ellis B,Weiss J,Kamper D

    更新日期：2014-09-22 00:00:00

  • Mechanical characterisation of porcine rectus sheath under uniaxial and biaxial tension.

    abstract：:Incisional hernia development is a significant complication after laparoscopic abdominal surgery. Intra-abdominal pressure (IAP) is known to initiate the extrusion of intestines through the abdominal wall, but there is limited data on the mechanics of IAP generation and the structural properties of rectus sheath. This...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2014.03.009

    authors： Lyons M,Winter DC,Simms CK

    更新日期：2014-06-03 00:00:00

  • Dynamic shear behavior of mandibular condylar cartilage is dependent on testing direction.

    abstract：:Little information is available on the direction-dependency of shear behavior in mandibular condylar cartilage. Therefore, we tested the hypothesis that such a dependency of the dynamic shear properties is present in mandibular condylar cartilage. From each of 17 condyles, two cartilage-bone plugs were dissected and t...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2007.12.012

    authors： Tanaka E,Iwabuchi Y,Rego EB,Koolstra JH,Yamano E,Hasegawa T,Kawazoe A,Kawai N,Tanne K

    更新日期：2008-01-01 00:00:00

  • Confocal-based cell-specific finite element modeling extended to study variable cell shapes and intracellular structures: the example of the adipocyte.

    abstract：:This communication extends the recently reported cell-specific finite element (FE) method in Slomka and Gefen (2010) in which geometrically realistic FE cell models are created from confocal microscopy scans for large deformation analyses. The cell-specific FE method is extended here in the following aspects: (i) we d...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2010.09.012

    authors： Or-Tzadikario S,Gefen A

    更新日期：2011-02-03 00:00:00

  • Computational modeling of neuromuscular response to swing-phase robotic knee extension assistance in cerebral palsy.

    abstract：:Predicting subject-specific responses to exoskeleton assistance may aid in maximizing functional gait outcomes, such as achieving full knee-extension at foot contact in individuals with crouch gait from cerebral palsy (CP). The purpose of this study was to investigate the role of volitional and non-volitional muscle a...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2019.02.025

    authors： Lerner ZF,Damiano DL,Bulea TC

    更新日期：2019-04-18 00:00:00

  • A mechanically decoupled two force component bicycle pedal dynamometer.

    abstract：:A design is presented for a bicycle pedal dynamometer that measures both normal and tangential forces (i.e. driving forces). Mechanical decoupling is used to reduce the cross-sensitivity of the dynamometer to loads doing no work to propel the bicycle. This obviates the need to measure all six loads for accurate data r...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(88)90144-3

    authors： Newmiller J,Hull ML,Zajac FE

    更新日期：1988-01-01 00:00:00

  • A physical model for simulating fusion of impaction-grafted morselized cancellous bone.

    abstract：:This article describes a method to simulate fusion of morselized cancellous bone. The morselized cancellous bone is mixed with an epoxy adhesive, in empirically determined proportions. The mixture is then impacted into a construct. When the epoxy cures, the morselized material fuses into a cohesive, contiguous structu...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(01)00032-x

    authors： Heiner AD,Brown TD

    更新日期：2001-06-01 00:00:00

  • High-acceleration whole body vibration stimulates cortical bone accrual and increases bone mineral content in growing mice.

    abstract：:Whole body vibration (WBV) is a promising tool for counteracting bone loss. Most WBV studies on animals have been performed at acceleration <1g and frequency between 30 and 90Hz. Such WBV conditions trigger bone growth in osteopenia models, but not in healthy animals. In order to test the ability of WBV to promote ost...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2016.04.031

    authors： Gnyubkin V,Guignandon A,Laroche N,Vanden-Bossche A,Malaval L,Vico L

    更新日期：2016-06-14 00:00:00

  • EMG and force production of some human shoulder muscles during isometric abduction.

    abstract：:Surface EMG was recorded in four subjects on three different occasions from the three parts of the deltoid, the clavicular part of the pectoralis major and from the infraspinatus muscles at different angles of abduction, in the frontal and scapular plane. The integrated EMG was related to the maximum values found for ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(85)90037-5

    authors： Ringelberg JA

    更新日期：1985-01-01 00:00:00

  • Effect of wedging on the flow characteristics past tilting disc aortic valve prosthesis.

    abstract：:To evaluate the efficacy of implanting a tilting disc aortic valve prosthesis in an angulated (wedged) supra-annular position, an in vitro experimental study was performed. The aortic valve prosthesis was mounted in an axi-symmetric valve chamber in a wedged position and incorporated in a mock circulatory system. Meas...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(86)90150-8

    authors： Chandran KB,Fatemi R,Hiratzka LF,Harris C

    更新日期：1986-01-01 00:00:00

  • Side-artifact errors in yield strength and elastic modulus for human trabecular bone and their dependence on bone volume fraction and anatomic site.

    abstract：:In the context of reconciling the mechanical properties of trabecular bone measured from in vitro mechanical testing with the true in situ behavior, recent attention has focused on the "side-artifact" which results from interruption of the trabecular network along the sides of machined specimens. The objective of this...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2007.05.008

    authors： Bevill G,Easley SK,Keaveny TM

    更新日期：2007-01-01 00:00:00

  • The Cybermouse: a simple method of describing the trajectory of the human mandible in three dimensions.

    abstract：:A simple method of recording the three-dimensional movements of the mandible together with up to 10 channels of other physiological data is described. The system is based on a commercially available device, the Cybermouse (IPC, Freemont, CA, U.S.A.), consisting of a lightweight ultrasonic emitter which can be attached...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(97)00012-2

    authors： Prinz JF

    更新日期：1997-06-01 00:00:00

  • Compact bone: numerical simulation of mechanical characteristics.

    abstract：:One of the main difficulties encountered in the numerical simulation of the anisotropic elastic characteristics of compact bone is to account for the Haversian microstructure when determining the overall macroscopic behavior. Engineering analyses of such problems are usually based on 'homogenized approximations'. Comp...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(93)90031-9

    authors： Crolet JM,Aoubiza B,Meunier A

    更新日期：1993-06-01 00:00:00

  • In-situ characterization of the uncrimping process of arterial collagen fibers using two-photon confocal microscopy and digital image correlation.

    abstract：:Uncrimping of collagen fibers in the arterial wall is an integral process in regulating the macro-level mechanical response of arteries. Uncrimping of collagen fibers leads to a gradual, but significant strain-stiffening response of the artery at physiological pressures and prevents overdistention at elevated pressure...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2013.08.001

    authors： Wang R,Brewster LP,Gleason RL Jr

    更新日期：2013-10-18 00:00:00

  • In vivo determination of normal and anterior cruciate ligament-deficient knee kinematics.

    abstract：:The objective of the current study was to use fluoroscopy to accurately determine the three-dimensional (3D), in vivo, weight-bearing kinematics of 10 normal and five anterior cruciate ligament deficient (ACLD) knees. Patient-specific bone models were derived from computed tomography (CT) data. 3D computer bone models...

    journal_title：Journal of biomechanics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jbiomech.2004.02.042

    authors： Dennis DA,Mahfouz MR,Komistek RD,Hoff W

    更新日期：2005-02-01 00:00:00

  • Improved walking function in laboratory does not guarantee increased community walking in stroke survivors: Potential role of gait biomechanics.

    abstract：:Reduced daily stepping in stroke survivors may contribute to decreased functional capacity and increased mortality. We investigated the relationships between clinical and biomechanical walking measures that may contribute to changes in daily stepping activity following physical interventions provided to participants w...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2019.05.011

    authors： Ardestani MM,Henderson CE,Hornby TG

    更新日期：2019-06-25 00:00:00

  • A mechanical approach to the longitudinal dispersion of gas flowing in human airways.

    abstract：:The aim of this work is to contribute to elucidating the mechanism underlying gas mixing in the human pulmonary airways. For this purpose, a particular attempt is made to analyse the fluid mechanical aspects of gaseous dispersion using bolus response methods. The experiments were performed on five normal subjects by i...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(85)90295-7

    authors： Ben Jebria A

    更新日期：1985-01-01 00:00:00

  • The three-dimensional determination of internal loads in the lower extremity.

    abstract：:A three-dimensional model of the lower limb containing 47 muscles was developed to study the differences between a two- and three-dimensional approach for determining internal loads, the role of the dynamic joint representation, and the behavior of different load-bearing criteria in walking and running. The problem of...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(97)00089-4

    authors： Glitsch U,Baumann W

    更新日期：1997-11-01 00:00:00

  • An approach to the simulation of fluid-structure interaction in the aortic valve.

    abstract：:A pair of finite element models has been employed to study the interaction of blood flow with the operation of the aortic valve. A three-dimensional model of the left ventricle with applied wall displacements has been used to generate data for the spatially and time-varying blood velocity profile across the aortic ape...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2004.10.038

    authors： Carmody CJ,Burriesci G,Howard IC,Patterson EA

    更新日期：2006-01-01 00:00:00

  • The consistency of maximum running speed measurements in humans using a feedback-controlled treadmill, and a comparison with maximum attainable speed during overground locomotion.

    abstract：:Consistent measurement of maximum running speed overground is problematic due to the difficulty in precise, continual measurement of speed, and the substantial workload in accelerating the body promoting the onset of fatigue. Treadmills remove the requirement for acceleration which enables more repeats. They also allo...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2009.07.024

    authors： Bowtell MV,Tan H,Wilson AM

    更新日期：2009-11-13 00:00:00

  • A comparison of Coulomb and pseudo-Coulomb friction implementations: Application to the table contact phase of gymnastics vaulting.

    abstract：:In the table contact phase of gymnastics vaulting both dynamic and static friction act. The purpose of this study was to develop a method of simulating Coulomb friction that incorporated both dynamic and static phases and to compare the results with those obtained using a pseudo-Coulomb implementation of friction when...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2011.07.022

    authors： Jackson MI,Hiley MJ,Yeadon MR

    更新日期：2011-10-13 00:00:00

  • Identification of a hemodynamic parameter for assessing treatment outcome of EDAS in Moyamoya disease.

    abstract：:This work is a novel attempt to incorporate computational fluid dynamics (CFD) techniques in the analysis of hemodynamic parameters of Moyamoya disease (MMD). Highly prevalent in Asian countries, MMD is characterised by progressive occlusion of the intracranial Internal Carotid Arteries (ICA). We intend to identify a ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2014.11.029

    authors： Karunanithi K,Han C,Lee CJ,Shi W,Duan L,Qian Y

    更新日期：2015-01-21 00:00:00

  • A method for automated control of belt velocity changes with an instrumented treadmill.

    abstract：:Increased practice difficulty during asymmetrical split-belt treadmill rehabilitation has been shown to improve gait outcomes during retention and transfer tests. However, research in this area has been limited by manual treadmill operation. In the case of variable practice, which requires stride-by-stride changes to ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2015.11.017

    authors： Hinkel-Lipsker JW,Hahn ME

    更新日期：2016-01-04 00:00:00

  • The vesico-urethral pressuregram analysis of urethral function under stress.

    abstract：:About one-third of older multiparous women are prone to stress urinary incontinence (SUI): unwanted urine loss during activities which suddenly raise intra-abdominal pressure. In this paper we describe and test a method for visualizing and analyzing the function of the urinary continence control system (CCS) under str...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(97)81291-2

    authors： Kim KJ,Ashton-Miller JA,Strohbehn K,DeLancey JO,Schultz AB

    更新日期：1997-01-01 00:00:00

  • In vitro electro-mechanical characterization of human knee articular cartilage of different degeneration levels: a comparison with ICRS and Mankin scores.

    abstract：:In the present study, the electro-mechanical properties of human knee articular cartilage were measured in vitro. An arthroscopic measurement tool was used to measure streaming potential integral (SPI), after which creep indentation tests were performed. Additionally, degradation level of the tissue was determined in ...

    journal_title：Journal of biomechanics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jbiomech.2013.02.004

    authors： Abedian R,Willbold E,Becher C,Hurschler C

    更新日期：2013-04-26 00:00:00

  • Characterisation of vortex shedding in vascular anastomosis models using pulsed Doppler ultrasound.

    abstract：:Vortex shedding at vascular anastomoses were investigated in vitro using a 20 MHz pulsed-wave Doppler velocimeter. Centreline velocity measurements were made at various axial distances in simplified polyurethane models of proximal and distal end-to-side anastomoses of angles 15, 30, 45, 60 and 80 degrees using pulsati...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(99)00056-1

    authors： Gaupp S,Wang Y,How TV,Fish PJ

    更新日期：1999-07-01 00:00:00

  • Challenges in relating experimental hip implant fixation predictions to clinical observations.

    abstract：:Long-term clinical follow-up studies have shown that radiolucent lines at the cement interfaces of total hip replacement femoral components develop gradually, ultimately leading to loosening. In this experimental study, 32 synthetic femurs implanted with cemented femoral components were cyclically loaded with a dynami...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2010.10.006

    authors： Sangiorgio SN,Longjohn DB,Dorr LD,Ebramzadeh E

    更新日期：2011-01-11 00:00:00

  • Generating dynamic simulations of movement using computed muscle control.

    abstract：:Computation of muscle excitation patterns that produce coordinated movements of muscle-actuated dynamic models is an important and challenging problem. Using dynamic optimization to compute excitation patterns comes at a large computational cost, which has limited the use of muscle-actuated simulations. This paper int...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(02)00432-3

    authors： Thelen DG,Anderson FC,Delp SL

    更新日期：2003-03-01 00:00:00