Abstract:
:This communication extends the recently reported cell-specific finite element (FE) method in Slomka and Gefen (2010) in which geometrically realistic FE cell models are created from confocal microscopy scans for large deformation analyses. The cell-specific FE method is extended here in the following aspects: (i) we demonstrate that cell-specific FE is versatile enough to deal with cells of substantially different geometrical shapes. The examples of an "elongated" pre-adipocyte and a "round" mature adipocyte are used to demonstrate this feature. (ii) We demonstrate that cell-specific FE can be used to analyze the mechanical behavior of cells that incorporate complex intracellular structures and are subjected to large deformations--again through the example of an adipocyte which contains a multitude of lipid droplets, each having a different size and shape. By demonstrating feasibility of inclusion of such inhomogeneities in the cytoplasm, the present work paves the way for modeling cellular organelles such as Golgi bodies, lysosomes and mitochondria in mechanically loaded cells using cell-specific FE.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Or-Tzadikario S,Gefen Adoi
10.1016/j.jbiomech.2010.09.012subject
Has Abstractpub_date
2011-02-03 00:00:00pages
567-73issue
3eissn
0021-9290issn
1873-2380pii
S0021-9290(10)00498-7journal_volume
44pub_type
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journal_title:Journal of biomechanics
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journal_title:Journal of biomechanics
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pub_type: 临床试验,杂志文章
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