Abstract：
:Osteocytes actively regulate bone modeling and remodeling, direct skeletal mineralization, and regulate calcium/phosphate homeostasis and extracellular matrix metabolism; yet the specific role of osteocytes in maintaining bone structural integrity and strength is unknown. Studies have shown that the density of osteocytes decreases with age and estrogen deficiency, as seen in postmenopausal women. Here, we examined the relationships between osteocyte density and the related variables, including biomechanics, bone mineral density, microcrack and microstructure of vertebral trabeculae, in ovariectomized rats. We found that osteocyte density correlated with some of the parameters that determine the biomechanical quality of bone. Our findings suggest that osteocytes could play a crucial role in maintaining the mechanical quality of bone, and osteocyte density could be considered as an alternative index in assessing bone quality.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Ma YL,Dai RC,Sheng ZF,Jin Y,Zhang YH,Fang LN,Fan HJ,Liao EYdoi
10.1016/j.jbiomech.2008.01.017subject
Has Abstractpub_date
2008-01-01 00:00:00pages
1324-32issue
6eissn
0021-9290issn
1873-2380pii
S0021-9290(08)00031-6journal_volume
41pub_type
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