Abstract:
:Continuum finite element (FE) models of bones have become a standard pre-clinical tool to estimate bone strength. These models are usually based on clinical CT scans and material properties assigned are chosen as isotropic based only on the density distribution. It has been shown, however, that trabecular bone elastic behavior is best described as orthotropic. Unfortunately, the use of orthotropic models in FE analysis derived from CT scans is hampered by the fact that the measurement of a trabecular orientation (fabric) is not possible from clinical CT images due to the low resolution of such images. In this study, we explore the concept of using a database (DB) of high-resolution bone models to derive the fabric information that is missing in clinical images. The goal of this study was to investigate if models with fabric derived from a relatively small database can already produce more accurate results than isotropic models. A DB of 33 human proximal femurs was generated from micro-CT scans with a nominal isotropic resolution of 82 µm. Continuum FE models were generated from the images using a pre-defined mesh template in combination with an iso-anatomic mesh morphing tool. Each element within the mesh template is at a specific anatomical location. For each element within the cancellous bone, a spherical region around the element centroid with a radius of 2mm was defined. Bone volume fraction and the mean-intercept-length fabric tensor were analyzed for that region. Ten femurs were used as test cases. For each test femur, four different models were generated: (1) an orthotropic model based on micro-CT fabric measurements (gold standard), (2) an orthotropic model based on the fabric derived from the best-matched database model, (3) an isotropic-I model in which the fabric tensor was set to the identity tensor, and (4) a second isotropic-II model with its total bone stiffness fitted to the gold standard. An elastic-plastic damage model was used to simulate failure and post failure behavior during a fall to the side. The results show that all models produce a similar stress distribution. However, compared to the gold standard, both isotropic-I and II models underestimated the stress/damage distributions significantly. We found no significant difference between DB-derived and gold standard models. Compared to the gold standard, the isotropic-I models further underestimated whole bone stiffness by 26.3% and ultimate load by 14.5%, while these differences for the DB-derived orthotropic models were only 4.9% and 3.1% respectively. The results indicate that the concept of using a DB to estimate patient-specific anisotropic material properties can considerably improve the results. We expect that this approach can lead to more accurate results in particular for cases where bone anisotropy plays an important role, such as in osteoporotic patients and around implants.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Hazrati Marangalou J,Ito K,Cataldi M,Taddei F,van Rietbergen Bdoi
10.1016/j.jbiomech.2013.07.042subject
Has Abstractpub_date
2013-09-27 00:00:00pages
2356-62issue
14eissn
0021-9290issn
1873-2380pii
S0021-9290(13)00375-8journal_volume
46pub_type
杂志文章abstract::An apparatus was designed for mechanical compression of cultured articular cartilage explants with acylindrical plain-ended loading head (diameter 2-5 mm) driven by a stepping motor. A load cell under the culture dish was applied for feedback regulation utilizing a microprocessor-based control unit. The operating prog...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(89)90232-7
更新日期:1989-01-01 00:00:00
abstract::A more fundamental understanding about the act of manual lifting can be provided by the assessment of the total production of power and the power generated in joints. The present study is concerned with the validity of the estimations of these parameters. Four subjects lifted an 18.8 kg load while they were filmed and...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(92)90045-3
更新日期:1992-09-01 00:00:00
abstract::Little information is available on the direction-dependency of shear behavior in mandibular condylar cartilage. Therefore, we tested the hypothesis that such a dependency of the dynamic shear properties is present in mandibular condylar cartilage. From each of 17 condyles, two cartilage-bone plugs were dissected and t...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2007.12.012
更新日期:2008-01-01 00:00:00
abstract::Quantification of baseball hitting mechanics under game conditions help players to become successful batters and prevent injuries. Inertial measurement units (IMUs) can measure motion without any spatial restriction and are thus becoming a popular tool to investigate sports biomechanics. Biomechanical analysis of hitt...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.02.001
更新日期:2019-04-18 00:00:00
abstract::Wave speed (also called pulse wave velocity) is the speed by which disturbance travels along the medium and it depends on the mechanical and geometrical properties of the vessel and on the density of the blood. Wave speed is a parameter of clinical relevance because it is an indicator of arterial stiffness and cardiov...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.10.007
更新日期:2014-01-03 00:00:00
abstract::The purpose of this study was to investigate the effect of thickness, cross-sectional area and stiffness of intrinsic foot muscles on performance in single-leg stance balance tasks in healthy sedentary young females. This study included a total of 40 healthy sedentary young females between the ages of 19 and 35 years....
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2019.109530
更新日期:2020-01-23 00:00:00
abstract::The aim of this work is to specify which model of turbulence is the most adapted in order to predict the drag forces that a swimmer encounters during his movement in the fluid environment. For this, a Computational Fluid Dynamics (CFD) analysis has been undertaken with a commercial CFD code (Fluent). The problem was m...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.10.010
更新日期:2010-02-10 00:00:00
abstract::The purpose of the study was to compare the effects of a feedback-controlled treadmill (FeedbackTM) to a traditional fixed-speed treadmill (FixedTM) on spatiotemporal gait means, variability, and dynamics. The study also examined inter-session reliability when using the FeedbackTM. Ten young adults walked on the Feedb...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.11.051
更新日期:2019-01-23 00:00:00
abstract::Tripping is responsible for a large percentage of falls. Minimum toe clearance (MTC) during the swing phase of gait is commonly used to infer the probability of tripping (POT). However, there is limited empirical evidence to support the relationship between these two variables, and other measures of toe trajectory may...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.10.045
更新日期:2016-12-08 00:00:00
abstract::This study report documents the development of a finite element (FE) model for analyzing trauma in pregnant women involved in road accidents and help the design of a specific safety device. The model is representative of a 50th percentile pregnant woman at 26 weeks of pregnancy in sitting position. To achieve this, th...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.09.013
更新日期:2014-01-03 00:00:00
abstract::The multi-signal mechanical environment mammalian cells experience is often unaccounted for in current mechanical stimulation studies. To address this we developed a novel technique to induce dual integrated force inputs, uniaxial stretch and fluid shear stress and present here for the first time a vector logic-gate f...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.12.047
更新日期:2015-02-26 00:00:00
abstract::The objective of this work is to gain more insight into the processes of oral perception of food texture. Particularly, the limits for detectable thickness differences of objects, which are evaluated in the human mouth, are investigated. In a sensory study small, flexible circular disks (diameter in mm range) of varyi...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2007.04.012
更新日期:2007-01-01 00:00:00
abstract::Previous studies investigating the effects of shoe midsole hardness on running kinematics have often used male subjects from within a narrow age range. It is unknown whether shoe midsole hardness has the same kinematic effect on male and female runners as well as runners from different age categories. As sex and age h...
journal_title:Journal of biomechanics
pub_type: 临床试验,杂志文章
doi:10.1016/j.jbiomech.2012.03.027
更新日期:2012-06-01 00:00:00
abstract::The role of microcracking in cortical bone as a toughening mechanism has been investigated in conjunction with the variation in fracture toughness with crack length. Fracture toughness tests were conducted on miniaturised compact tension specimens made from human and bovine cortical bone and the resultant microstructu...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(97)00029-8
更新日期:1997-08-01 00:00:00
abstract::Healthy humans display a preference for walking at a stride frequency dependent on the inertial properties of their legs. Walking at preferred stride frequency (PSF) is predicted to maximize local dynamic stability, whereby sensitivity to intrinsic perturbations arising from natural variability inherent in biological ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.10.012
更新日期:2014-01-03 00:00:00
abstract::Individuals with spinal cord injury experience a rapid loss of bone mineral below the neurological lesion. The clinical consequence of this bone loss is a high rate of fracture around regions of the knee. The ability to predict the mechanical competence of bones at this location may serve as an important clinical tool...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.04.016
更新日期:2013-06-21 00:00:00
abstract::Bone strains resulting from physical activity are thought to be a primary driver of bone adaptation, but cannot be directly noninvasively measured. Because bone adapts nonuniformly, physical activity may make an important independent structural contribution to bone strength that is independent of bone mass and density...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.04.050
更新日期:2014-08-22 00:00:00
abstract::In vivo loads acting at the hip joint have so far only been measured in few patients and without detailed documentation of gait data. Such information is required to test and improve wear, strength and fixation stability of hip implants. Measurements of hip contact forces with instrumented implants and synchronous ana...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(01)00040-9
更新日期:2001-07-01 00:00:00
abstract::In this study, an experimental framework is described that allows pressurization of intact, human atherosclerotic carotid samples (inflation testing), in combination with ultrasound imaging. Eight fresh human carotid endarterectomy samples were successfully pressurized and tested. About 36 2-D (+t) ultrasound datasets...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.01.016
更新日期:2014-03-03 00:00:00
abstract::Hip joint dislocations related to total hip arthroplasty (THA) are a common complication especially in the early postoperative course. The surgical approach, the alignment of the prosthetic components, the range of motion and the muscle tone are known factors influencing the risk of dislocation. A further factor that ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.05.013
更新日期:2014-08-22 00:00:00
abstract::Computational models have recently been developed to replicate experimental conditions present in the Stanmore knee wear simulator. These finite element (FE) models, which provide a virtual platform to evaluate total knee replacement (TKR) mechanics, were validated through comparisons with experimental data for a spec...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2005.07.029
更新日期:2006-01-01 00:00:00
abstract::Muscle stiffness increases faster than muscle force during the rising phase of a tetanic contraction, and decreases more slowly during the falling phase. Different models of the stiffness arising from series, parallels, and crossbridge elasticity were compared to determine whether they could account quantitatively for...
journal_title:Journal of biomechanics
pub_type: 杂志文章,评审
doi:10.1016/0021-9290(90)90037-4
更新日期:1990-01-01 00:00:00
abstract::Split-belt treadmills (SBTM) contain force plates under each belt that measure ground reaction force (GRF). Initial contact (IC) detection for each gait cycle obtained from the GRF is used for calculating temporal gait parameters (e.g., gait variability, step time, stride time). Occasionally, the participant steps wit...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109963
更新日期:2020-09-18 00:00:00
abstract::The elastic modulus of bioengineered materials has a strong influence on the phenotype of many cells including cardiomyocytes. On polyacrylamide (PAA) gels that are laminated with ligands for integrins, cardiac myocytes develop well organized sarcomeres only when cultured on substrates with elastic moduli in the range...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.11.023
更新日期:2012-03-15 00:00:00
abstract::The paper analyzes the connection between microstructure of the osteonal cortical bone and its overall elastic properties. The existing models either neglect anisotropy of the dense tissue or simplify cortical bone microstructure (accounting for Haversian canals only). These simplifications (related mostly to insuffic...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.08.019
更新日期:2014-10-17 00:00:00
abstract::Nerve compression due to intervertebral disc (IVD) bulging is a known mechanism for low back pain and typically occurs in the posterior region of the disc. Most in vitro studies are limited in the ability to quantify the magnitude of bulging on the posterior aspect of the disc due to the boney structures that occlude ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109713
更新日期:2020-05-07 00:00:00
abstract::Patient selection for lateral retinacular release (LRR) and its efficacy are controversial. Iatrogenic medial subluxation can occur with inappropriate LRR. The aim of this study was to determine the reduction in patellofemoral stability with progressively more extensive LRR. The force required to displace the patella ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.11.003
更新日期:2009-02-09 00:00:00
abstract::Computational models have the potential to provide precise estimates of stresses and strains associated with sites of coronary plaque rupture. However, lack of adequate mathematical description of diseased human vessel wall mechanical properties is hindering computational accuracy. The goal of this study is to charact...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.11.019
更新日期:2012-03-15 00:00:00
abstract::Increased knee flexion during stance is a common gait deviation in the child with cerebral palsy (CP), with distal hamstring lengthening surgeries being an accepted course of treatment. Post-operatively, improvements in gait kinematics have been reported, however little change is noted in the patterns of muscle activi...
journal_title:Journal of biomechanics
pub_type: 临床试验,杂志文章
doi:10.1016/j.jbiomech.2007.01.001
更新日期:2007-01-01 00:00:00
abstract::The influence of the ductility of bone tissue on whole-bone strength represents a fundamental issue of multi-scale biomechanics. To gain insight, we performed a computational study of 16 human proximal femurs and 12 T9 vertebral bodies, comparing the whole-bone strength for the two hypothetical bounding cases of fully...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.02.066
更新日期:2015-05-01 00:00:00