Abstract：
:The multi-signal mechanical environment mammalian cells experience is often unaccounted for in current mechanical stimulation studies. To address this we developed a novel technique to induce dual integrated force inputs, uniaxial stretch and fluid shear stress and present here for the first time a vector logic-gate framework to characterize cellular response as a function of cytoskeletal reorganization. Using this framework we found that under fluid shear stress and uniaxial stretch NIH 3T3 fibroblasts responded by the Stretch OR Shear vector logic-gate and HUVECs responded by the NOT Stretch OR Shear vector logic-gate. We further developed a parsimonious model of cellular response to multiple mechanical stimuli, which provides a unifying model that captured the experimental response of both cell types.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Steward RL Jr,Tan C,Cheng CM,LeDuc PRdoi
10.1016/j.jbiomech.2014.12.047subject
Has Abstractpub_date
2015-02-26 00:00:00pages
613-20issue
4eissn
0021-9290issn
1873-2380pii
S0021-9290(14)00715-5journal_volume
48pub_type
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