Abstract：
:The optimal fluid administration protocol for critically ill perioperative patients is hard to estimate due to the lack of tools to directly measure the patient fluid status. This results in the suboptimal clinical outcome of interventions. Previously developed predictive mathematical models focus on describing the fluid exchange over time but they lack clinical applicability, since they do not allow prediction of clinically measurable indices. The aim of this study is to make a first step towards a model predictive clinical decision support system for fluid administration, by extending the current fluid exchange models with a regulated cardiovascular circulation, to allow prediction of these indices. The parameters of the model were tuned to correctly reproduce experimentally measured changes in arterial pressure and heart rate, observed during infusion of normal saline in healthy volunteers. With the resulting tuned model, a different experiment including blood loss and infusion could be reproduced as well. These results show the potential of using this model as a basis for a decision support tool in a clinical setting.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Rosalina TT,Bouwman RA,van Sambeek MRHM,van de Vosse FN,Bovendeerd PHMdoi
10.1016/j.jbiomech.2019.03.002subject
Has Abstractpub_date
2019-05-09 00:00:00pages
4-11eissn
0021-9290issn
1873-2380pii
S0021-9290(19)30161-7journal_volume
88pub_type
杂志文章abstract：:Arterial embolism is responsible for the death of lots of people who suffers from heart diseases. The major risk of embolism in upper limbs is that the ruptured particles are brought into the brain, thus stimulating neurological symptoms or causing the stroke. We presented a computational model using fluid-structure i...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.01.020
更新日期：2012-04-30 00:00:00
abstract：:Endothelial cells regulate vascular tone and mural remodelling in a shear-dependent manner that is commonly assumed to keep wall shear stress constant across arteries and species. Allometric arguments show that aortic flow velocity is constant across species, a deduction that is consistent with much experimental data,...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.07.020
更新日期：2007-01-01 00:00:00
abstract：:An experimental study was carried out on asymmetrical abdominal aortic aneurysm (AAA) to analyse the physiological flows involved. Velocity measurements were performed using particle image velocimetry. Resting and exercise flow rates were investigated in models with rigid and compliant walls to assess the parameters a...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.11.017
更新日期：2007-01-01 00:00:00
abstract：:Persons with lower limb amputation (LLA) perceive altered motions of the trunk/pelvis during activities of daily living as contributing factors for low back pain. When walking (at a singular speed), larger trunk motions among persons with vs. without LLA are associated with larger spinal loads; however, modulating wal...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.11.026
更新日期：2018-03-21 00:00:00
abstract：:To prevent spinal cord injury, optimize treatments for it, and better understand spinal cord pathologies such as spondylotic myelopathy, the interaction between the spinal column and the spinal cord during injury and pathology must be understood. The spinal cord is a complex and very soft tissue that changes propertie...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.01.036
更新日期：2009-05-11 00:00:00
abstract：:In this study the investigations made on about 50 trunk tissue densities are described. They were performed on ten cadavers of both sexes within 24 h of the moment of death. They were 20-40 yr old. The weight of each tissue was measured on a laboratory scale and the volume by placing the tissue in a pycnometer filled ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(90)90360-f
更新日期：1990-01-01 00:00:00
abstract：:Within the context of improving knowledge of the structure-function relations for trabecular bone for cyclic loading, we hypothesized that the S-N curve for cyclic compressive loading of trabecular bone, after accounting for differences in monotonic strength behavior, does not depend on either site or species. Thirty-...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(03)00245-8
更新日期：2004-02-01 00:00:00
abstract：:The forces and moments acting at the hip joint influence the long-term stability of the fixation of endoprostheses and the course of coxarthrosis. These loads may depend on the kind of footwear and the walking or running style. These factors were investigated in a patient with instrumented hip implants. He wore differ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)00129-r
更新日期：1995-07-01 00:00:00
abstract：:Rapid force generation across submaximal levels has been evaluated with the rate of force development scaling factor (RFD-SF) in different isometric tasks, while such measurement was still not verified in dynamic tasks. Our study was designed to evaluate the feasibility of the RFD-SF in dynamic drop jump (DJ) task (RF...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109980
更新日期：2020-09-18 00:00:00
abstract：:The multi-signal mechanical environment mammalian cells experience is often unaccounted for in current mechanical stimulation studies. To address this we developed a novel technique to induce dual integrated force inputs, uniaxial stretch and fluid shear stress and present here for the first time a vector logic-gate f...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.12.047
更新日期：2015-02-26 00:00:00
abstract：:The principal motivation for the present work was the study of the kinetics of anaerobic metabolism. A new mathematical model of the bioenergetics of sprinting, incorporating a three-equation representation of anaerobic metabolism, is developed. Results computed using the model are compared with measured data from the...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00035-x
更新日期：2000-08-01 00:00:00
abstract：:We investigated the microstructural basis of a reduced stress concentration around the primary nutrient foramen of the equine third metacarpus. We quantified the spatial variations of compositional parameters (mineral content, volume fraction, histological architecture, and osteonal trajectories) from microradiographs...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(03)00130-1
更新日期：2003-10-01 00:00:00
abstract：:The estimation of the skeletal motion obtained from marker-based motion capture systems is known to be affected by significant bias caused by skin movement artifacts, which affects joint center and rotation axis estimation. Among different techniques proposed in the literature, that based on rigid body model, still th...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2004.09.032
更新日期：2005-11-01 00:00:00
abstract：:The physical environment surrounding an animal has a significant impact on its behavior. The nematode Caenorhabditis elegans (C. elegans) has proved to be an excellent choice for understanding the adaptability of organisms crawling on soft surfaces. In this work, we investigate the modulation of C. elegans' behavioral...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.02.015
更新日期：2017-04-11 00:00:00
abstract：:A new strain energy function for the hyperelastic modelling of ligaments and tendons based on the geometrical arrangement of their fibrils is derived. The distribution of the crimp angles of the fibrils is used to determine the stress-strain response of a single fascicle, and this stress-strain response is used to det...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.11.031
更新日期：2015-01-21 00:00:00
abstract：:Understanding proximal femur fracture may yield new targets for fracture prevention screening and treatment. The goal of this study was to characterize force-displacement and failure behaviours in the proximal femur between displacement control and impact loading fall simulations. Twenty-one human proximal femurs were...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.06.040
更新日期：2014-11-28 00:00:00
abstract：:This paperwork deals with the obtaining and characterisation of new acrylic cements for bone surgery. The final mixture of cement contains derivatives of methacryloyloxyethyl phosphate, methacrylic acid or 2-acrylamido-2-methyl-1-propane sulphonic acid. The idea of using these monomers is sustained by their ability to...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.05.002
更新日期：2007-01-01 00:00:00
abstract：:The majority of fall-related accidents are during stair ambulation-occurring commonly at the top and bottom stairs of each flight, locations in which individuals are transitioning to stairs. Little is known about how individuals adjust their biomechanics in anticipation of walking-stair transitions. We identified the ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.12.041
更新日期：2016-02-29 00:00:00
abstract：:Dynamic balance in the frontal plane requires active control, which is accomplished largely through control of mediolateral foot placement. Individuals without mobility impairments have the ability to compensate for variability in foot-placement to maintain their balance; however, it is unknown how individuals respond...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.110213
更新日期：2020-12-28 00:00:00
abstract：:This study proposed a revision to the Rosenstein's method of numerical calculation of the largest Lyapunov exponent (LyE) to make it more robust to noise. To this aim, the effect of increasing number of initial neighboring points on the LyE value was investigated and compared to values obtained by filtering the time s...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.01.013
更新日期：2019-03-06 00:00:00
abstract：:We present a comparison of the flow characteristics in an idealized smooth trachea model and a second model which has a roughness simulating cartilaginous rings. We use refractive index-matched particle image velocimetry (PIV) to measure the velocity field in a two-generation model of the trachea and main bronchi. The...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.03.043
更新日期：2016-06-14 00:00:00
abstract：:Computational models have recently been developed to replicate experimental conditions present in the Stanmore knee wear simulator. These finite element (FE) models, which provide a virtual platform to evaluate total knee replacement (TKR) mechanics, were validated through comparisons with experimental data for a spec...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.07.029
更新日期：2006-01-01 00:00:00
abstract：:This study investigates the nature of deformation and differences in the mechanisms of fracture and properties of dentine where there has been a loss of moisture, as may occur with removal of the pulp in the endodontic treatment of teeth. Controlled fracture toughness testing was conducted on bovine teeth to determine...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(02)00327-5
更新日期：2003-02-01 00:00:00
abstract：:A novel technique to measure in vitro disc pressures in human cervical spine specimens was developed. A miniature pressure transducer was used and an insertion technique was designed to minimise artefacts due to insertion. The technique was used to measure the intradiscal pressure in cervical spines loaded in pure axi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00205-0
更新日期：2001-04-01 00:00:00
abstract：:Body segment parameters (BSP) are essential input for the computations in kinetics of motion applied in the field of biomechanics. These data are usually obtained from population-specific predictive equations which present limitations in being representative of the population under study. More recently, medical imagin...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.10.036
更新日期：2009-02-09 00:00:00
abstract：:Understanding the mechanical response of the brain to external loadings is of critical importance in investigating the pathological conditions of this tissue during injurious conditions. Such injurious loadings may occur at high rates, for example among others, during road traffic or sport accidents, falls, or due to ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.01.007
更新日期：2019-02-14 00:00:00
abstract：:Knee joint sounds contain information on joint health, morphology and loading. These acoustic signals may be elicited by further, as yet unknown factors. By assessing potential elicitors and their relative contributions to the acoustic signal, we investigated the validity of vibroarthrographic assessments during diffe...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109939
更新日期：2020-08-26 00:00:00
abstract：:Cross-linked polyethylene foam (Plastazote) has been used in the management of painful foot disorders occurring in a number of disease processes. A series of mechanical tests have been performed under varying clinically encountered conditions to show a relationship between the deformation of the material and the load ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(84)90101-5
更新日期：1984-01-01 00:00:00
abstract：:The purpose of this study was to investigate the effects of temperature, velocity and load on the gliding resistance (GR) of flexor digitorum profundus (FDP) tendons in a human cadaver model. A total of 40 FDP tendons from the index through small digits of ten human cadavers were tested to assess the effect of tempera...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.01.011
更新日期：2011-04-29 00:00:00
abstract：:This paper addresses the question of whether maximal vertical jump height depends on initial jumping posture. A direct dynamics computer simulation approach was used to avoid subject preference and practice effects. The human body was modeled as four rigid segments connected by ideal hinge joints, with movement constr...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(96)00030-9
更新日期：1996-09-01 00:00:00
