Abstract:
:Endothelial cells regulate vascular tone and mural remodelling in a shear-dependent manner that is commonly assumed to keep wall shear stress constant across arteries and species. Allometric arguments show that aortic flow velocity is constant across species, a deduction that is consistent with much experimental data, but the same arguments also show that the shear stress experienced by aortic endothelium will depend inversely on body mass to the 3/8th power, and hence will be 20-fold higher in mice than in men. This conclusion is robust and has important implications for the study of shear-dependent vascular biology and pathology.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Weinberg PD,Ross Ethier Cdoi
10.1016/j.jbiomech.2006.07.020subject
Has Abstractpub_date
2007-01-01 00:00:00pages
1594-8issue
7eissn
0021-9290issn
1873-2380pii
S0021-9290(06)00280-6journal_volume
40pub_type
杂志文章abstract::Experimental evidence demonstrates that collagen cross-linking in bone tissue significantly influences its deformation and failure behavior yet difficulties exist in determining the independent biomechanical effects of collagen cross-linking using in vitro and in vivo experiments. The aim of this study is to use a nan...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.02.017
更新日期:2008-01-01 00:00:00
abstract::The movements of the human jaw are controlled by the forces produced by the masticatory muscles. As the jaw moves, these muscles change in length and their force producing units, the sarcomeres, change in length simultaneously. The lengths and length changes of the sarcomeres are determinants for the forces they are a...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(97)00047-x
更新日期:1997-09-01 00:00:00
abstract::The present study investigated the feasibility and reliability of continuous relative phase (CRP) and deviation phase (DP) to assess intersegmental hind limb coordination pattern and coordination variability in rats during walking. Twenty-six adult rats walked at 8 m/min, 12 m/min and 16 m/min while two-dimensional ki...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.03.045
更新日期:2018-05-17 00:00:00
abstract::Mechanical properties of abdominal and thoracic arteries of 2mm in diameter were determined from adults Wistar rats. A tensile testing instrument was used to obtain stress/strain curves with arteries immersed in physiological buffer at 37 degrees C. A displacement was applied on all arteries with various frequencies (...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.04.017
更新日期:2008-07-19 00:00:00
abstract::Accidentology data showed that liver is often injured in car crashes; three types of injuries occur: hematoma, laceration and vessel failure. This paper focuses on surface laceration, which involves liver capsule and hepatic parenchyma. Liver capsule behavior has been studied but its failure properties are still uncle...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.03.038
更新日期:2010-08-10 00:00:00
abstract::Previous research on slip and fall accidents has suggested that pressurized fluid between the shoe and floor is responsible for initiating slips yet this effect has not been verified experimentally. This study aimed to (1) measure hydrodynamic pressures during slipping for treaded and untreaded conditions; (2) determi...
journal_title:Journal of biomechanics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jbiomech.2013.10.046
更新日期:2014-01-22 00:00:00
abstract::Despite numerous reports on isometric force depression, few reports have quantified force depression during active muscle shortening (dynamic force depression). The purpose of this investigation was to determine the influence of shortening history on isometric force following active shortening, force during isokinetic...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.10.041
更新日期:2010-03-03 00:00:00
abstract::A computational model of adaptive bone remodelling is formulated as an optimization problem of instantaneous changes in microstructure that minimize a functional describing the structure quality rate. Microstructure is locally described by a set of scalar geometric parameters. Macroscopic (continuum) elastic propertie...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.09.045
更新日期:2010-02-10 00:00:00
abstract::To study the effect of pressure changes on the opening angle of arteries in organ culture, tubular segments of porcine common carotid arteries were cultured with pulsatile flow perfusion under hypertensive (150+/-20 mmHg), normotensive (100+/-20 mmHg), or hypotensive (30+/-10 mmHg) pressure while maintaining the arter...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2005.08.003
更新日期:2006-01-01 00:00:00
abstract::The effect of non-habitual physical activity on bone architecture in the rat humeral shaft was examined. Two groups of rats were trained to swim for 1 h a day, for 20 weeks, at two training levels. The control group consisted of sedentary rats. Parameters of cross-sectional bone morphology (cross-section areas, princi...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(89)90068-7
更新日期:1989-01-01 00:00:00
abstract::The understanding of impact mechanics during locomotion is important for research within the fields of injury prevention and footwear design. Instrumented missiles offer a worthy solution to the lack of control inherent in in vivo activities and to the isolated nature of tissue studies. However, missiles cannot mimic ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(95)00002-y
更新日期:1995-09-01 00:00:00
abstract::Locomotion involves complex neural networks responsible for automatic and volitional actions. During locomotion, motor strategies can rapidly compensate for any obstruction or perturbation that could interfere with forward progression. In this pilot study, we examined the contribution of interlimb pathways for evoking...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.04.042
更新日期:2015-08-20 00:00:00
abstract::Knowledge of ligament fibre recruitment at the human ankle joint complex is a fundamental prerequisite for analysing mobility and stability. Previous experimental and modelling studies have shown that ankle motion must be guided by fibres within the calcaneofibular and tibiocalcaneal ligaments, which remain approximat...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2004.02.043
更新日期:2004-12-01 00:00:00
abstract::Despite substantial evidence for the central role of hemodynamic shear stress in the functional integrity of vascular endothelial cells, hemodynamic and molecular regulation of the endocardial endothelium lining the heart chambers remains understudied. We propose that regional differences in intracardiac hemodynamics ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.11.018
更新日期:2017-01-04 00:00:00
abstract::Tendons are elastic structures that connect muscle to the skeletal system and transmit force relative to the amount of stretch they experience. The mechanical properties of human tendons are difficult to measure non-invasively, so generic values are often assumed in musculoskeletal models to represent all subjects. We...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.06.009
更新日期:2015-09-18 00:00:00
abstract::There appears a linear relationship between small increases in running speed and cardiovascular health benefits. Encouraging or coaching recreational runners to increase their running speed to derive these health benefits might be more effective if their joint level kinematic and kinetic strategy was understood. The a...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.02.010
更新日期:2018-04-11 00:00:00
abstract::Topically applied microbicide gels can provide a self-administered and effective strategy to prevent sexually transmitted infections (STIs). We have investigated the interplay between vaginal tissue elasticity and the yield-stress of non-Newtonian fluids during microbicide deployment. We have developed a mathematical ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.01.049
更新日期:2015-06-25 00:00:00
abstract::The objective of this work is to gain more insight into the processes of oral perception of food texture. Particularly, the limits for detectable thickness differences of objects, which are evaluated in the human mouth, are investigated. In a sensory study small, flexible circular disks (diameter in mm range) of varyi...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2007.04.012
更新日期:2007-01-01 00:00:00
abstract::Despite significant evidence regarding the increased risk of cartilage degeneration due to traumatic injuries to joints, there is still a lack of understanding of the mechanisms underlying osteoarthritis development following a joint injury. Injuries in knee cartilage are often characterized by lesions or tears. In ad...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109970
更新日期:2020-09-18 00:00:00
abstract::In order to move the finger the tendon force must overcome the gliding resistance of the tendon as well as the forces to move the joints, finger inertias, and external load. These sources, combined, make up the work of flexion (WOF) which has been experimentally used to evaluate the finger function. In this study, we ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(02)00300-7
更新日期:2003-02-01 00:00:00
abstract::Progression and rupture of atherosclerotic plaques in coronary and carotid arteries are the key processes underlying myocardial infarctions and strokes. Biomechanical stress analyses to compute mechanical stresses in a plaque can potentially be used to assess plaque vulnerability. The stress analyses strongly rely on ...
journal_title:Journal of biomechanics
pub_type: 杂志文章,评审
doi:10.1016/j.jbiomech.2014.01.019
更新日期:2014-03-03 00:00:00
abstract::Adverse wall shear stress (WSS) patterns are known to play a key role in the localisation, formation, and progression of intracranial aneurysms (IAs). Complex region-specific and time-varying aneurysmal WSS patterns depend both on vascular morphology as well as on variable systemic flow conditions. Computational fluid...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.10.005
更新日期:2016-12-08 00:00:00
abstract::Throughout life, bone is continuously turning over by the well-regulated processes of bone formation and resorption. Everyday activities damage bone, and this damage is normally repaired in a continuous remodelling process. When an imbalance in this remodelling process occurs, bones may become more susceptible to frac...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(00)00215-3
更新日期:2001-04-01 00:00:00
abstract::The physical environment surrounding an animal has a significant impact on its behavior. The nematode Caenorhabditis elegans (C. elegans) has proved to be an excellent choice for understanding the adaptability of organisms crawling on soft surfaces. In this work, we investigate the modulation of C. elegans' behavioral...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.02.015
更新日期:2017-04-11 00:00:00
abstract::Lumbar interbody fusion is currently the gold standard in treating patients with disc degeneration or segmental instability. Despite it having been used for several decades, the non-union rate remains high. A failed fusion is frequently attributed to an inadequate mechanical environment after instrumentation. Finite e...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.03.009
更新日期:2018-04-27 00:00:00
abstract::The purpose of this study was to apply the Floating Axis analysis technique to the elbow joint, and to verify its ability to quantify clinically relevant radiohumeral translation in vitro using an electromagnetic tracking device. Of particular interest was the ability to quantify changes in anterior-posterior radial h...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(03)00103-9
更新日期:2003-08-01 00:00:00
abstract::Chondrocytes in articular cartilage are regularly subjected to compression and recovery due to dynamic loading of the joint. Previous studies have investigated the elastic and viscoelastic properties of chondrocytes using micropipette aspiration techniques, but in order to calculate cell properties, these studies have...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2004.11.006
更新日期:2006-01-01 00:00:00
abstract::Anterior cruciate ligament (ACL) volume and T2∗ relaxation times from magnetic resonance (MR) images have been previously shown to predict the structural properties of healing ligaments. We investigated whether MR imaging scan resolution and condition (in vivo, in situ, or ex vivo) affected ACL volume and T2∗ relaxati...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.03.010
更新日期:2017-05-03 00:00:00
abstract::In this study, the effect of dehydration-hydration based sublamellar dimensional change on bone anisotropy was used as a tool to understand sublamellar organization of mineralized collagen fibrils. Bone consists of hydroxyapatite, Type I Collagen, mucopolysaccharides and bone fluid, which associates with bone constitu...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109737
更新日期:2020-05-07 00:00:00
abstract::A new six-degree-of-freedom force transducer has been manufactured, with the sensitivity to measure forces in the range +/-100 N and moments of up to +/-5 Nm. The transducer incorporates two mechanical components: shear forces and bending moments are measured via a strain-gauged tubular section whilst axial forces are...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(99)00054-8
更新日期:1999-07-01 00:00:00