Abstract：
:Topically applied microbicide gels can provide a self-administered and effective strategy to prevent sexually transmitted infections (STIs). We have investigated the interplay between vaginal tissue elasticity and the yield-stress of non-Newtonian fluids during microbicide deployment. We have developed a mathematical model of tissue deformation driven spreading of microbicidal gels based on thin film lubrication approximation and demonstrated the effect of tissue elasticity and fluid yield-stress on the spreading dynamics. Our results show that both elasticity of tissue and yield-stress rheology of gel are strong determinants of the coating behavior. An optimization framework has been demonstrated which leverages the flow dynamics of yield-stress fluid during deployment to maximize retention while reaching target coating length for a given tissue elasticity.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Anwar MR,Camarda KV,Kieweg SLdoi
10.1016/j.jbiomech.2015.01.049subject
Has Abstractpub_date
2015-06-25 00:00:00pages
1625-30issue
9eissn
0021-9290issn
1873-2380pii
S0021-9290(15)00065-2journal_volume
48pub_type
杂志文章abstract：:Traumatic damage to the brainstem occurs frequently when the brain skull complex experiences injurious loading especially during those traumatic situations that produce diffuse axonal injury (DAI). DAI has been shown to be dependent on load direction and correlated with regional tissue deformation in response to rotat...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(98)00068-2
更新日期：1998-09-01 00:00:00
abstract：:The paper defines the term coordination interval (CI), suggesting that it should replace the term electromechanical delay (EMD), if this parameter is determined in vivo for a muscle functioning in a biomechanical system with considerable mobility, but not in a kinematic pair with one degree of rotational freedom (DOF)...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)90211-9
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abstract：:The ability to monitor the healing of bone fractures is crucially important in their treatment. The aim of the present study was to develop and validate an objective method for monitoring fracture healing based on bone vibrational response. An analytic model was formulated, with which the mechanical parameters at the ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(90)90060-g
更新日期：1990-01-01 00:00:00
abstract：:The purpose of this study was to employ subject-specific computer models to evaluate the interaction of glenohumeral range-of-motion and Hill-Sachs humeral head bone defect size on engagement and shoulder dislocation. We hypothesized that the rate of engagement would increase as defect size increased, and that greater...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.11.001
更新日期：2016-02-29 00:00:00
abstract：:As a hybrid between a hypodermic needle and transdermal patch, we have used microfabrication technology to make arrays of micron-scale needles that transport drugs and other compounds across the skin without causing pain. However, not all microneedle geometries are able to insert into skin at reasonable forces and wit...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2003.12.010
更新日期：2004-08-01 00:00:00
abstract：:Proper cup alignment is crucial in total hip arthroplasty for reducing impingement risks, dislocations and wear. The Lewinnek "safe zone" is often used in clinical routine. This safe zone does not consider functional aspects and dislocation can occur even when the cup is oriented within the safe zone. Functional safe ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.10.020
更新日期：2019-01-03 00:00:00
abstract：:The swimming process by which mammal spermatozoa progress towards an egg within the reproductive organs is important in achieving successful internal fertilization. The viscosity of oviductal mucus is more than two orders of magnitude greater than that of water, and oviductal mucus also has non-Newtonian properties. I...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.08.005
更新日期：2015-09-18 00:00:00
abstract：:Progress in medicine and higher expectation of quality of life has led to a higher demand for several dental and medical treatments. This increases the occurrence of situations in which orthodontic treatment is complicated by pathological conditions, medical therapies and drugs. Together with experiments, computer mod...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.10.037
更新日期：2013-02-01 00:00:00
abstract：:The forces and moments acting at the hip joint influence the long-term stability of the fixation of endoprostheses and the course of coxarthrosis. These loads may depend on the kind of footwear and the walking or running style. These factors were investigated in a patient with instrumented hip implants. He wore differ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)00129-r
更新日期：1995-07-01 00:00:00
abstract：:Long-term clinical follow-up studies have shown that radiolucent lines at the cement interfaces of total hip replacement femoral components develop gradually, ultimately leading to loosening. In this experimental study, 32 synthetic femurs implanted with cemented femoral components were cyclically loaded with a dynami...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.10.006
更新日期：2011-01-11 00:00:00
abstract：:To establish whether conducting polymer-coated fabric sensors could be used to monitor breast motion, vertical breast motion of two large breasted women (C+ bra cup) was simultaneously monitored using an OPTOTRAK 3020 motion analysis system (200 Hz) and polymer-coated fabric sensors linked to a custom-made Bluetooth t...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.01.020
更新日期：2007-01-01 00:00:00
abstract：:Time-domain-based one-dimensional wave propagation models of the arterial system are preferable over one-dimensional wave propagation models in the frequency domain since the latter neglect the non-linear convection forces present in the physiological situation, especially when the vessel is tapered. Moreover, one-dim...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.09.014
更新日期：2008-01-01 00:00:00
abstract：:Hamstring muscle strain injury is one of the most commonly seen injuries in sports such as track and field, soccer, football, and rugby. The purpose of this study was to advance our understanding of the mechanisms of hamstring muscle strain injuries during over ground sprinting by investigating hamstring muscle-tendon...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.09.005
更新日期：2008-11-14 00:00:00
abstract：:The patchy distribution of atherosclerosis within arteries is widely attributed to local variation in haemodynamic wall shear stress (WSS). A recently-introduced metric, the transverse wall shear stress (transWSS), which is the average over the cardiac cycle of WSS components perpendicular to the temporal mean WSS vec...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.11.035
更新日期：2017-01-04 00:00:00
abstract：:A finite element model of a bioprosthetic heart valve was developed to determine the influence of the stent height on leaflet stresses under various pressure loading conditions after valve closure. A nonlinear solution was used to obtain the stresses in the leaflets for stent heights of 14.6 mm, 19.0 mm and 22.0 mm re...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(86)90199-5
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abstract：:Strength, or maximum joint torque, is a fundamental factor governing human movement, and is regularly assessed for clinical and rehabilitative purposes as well as for research into human performance. This study aimed to identify the most appropriate protocol for fitting a maximum voluntary torque function to experimen...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.11.024
更新日期：2011-03-15 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.11.041
更新日期：2016-04-11 00:00:00
abstract：:The goal of the present study was to assess the effects of age and sex on trunk motor control. Fifty healthy adults (aged between 19 and 67 years, 28 males) participated in this study. Trunk motor control was assessed using force-controlled perturbations directly applied to the trunk. Admittance (inverse of lumped int...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109607
更新日期：2020-03-26 00:00:00
abstract：:Mechanical strength along with high biocompatibility and water absorbing are among main characteristics of a desirable scaffold for cartilage tissue engineering. Having these properties, polyvinyl alcohol (PVA) can be a good option for constructing cartilage tissue engineering scaffolds. In this study, PVA hydrogel wa...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.109525
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abstract：:Although micromechanical finite-element models are being increasingly used to help interpret the results of bio-mechanical tests, there has not yet been a systematic study of the numerical errors and uncertainties that occur with these methods. In this work, finite-element models of human L1 vertebra have been used to...
journal_title：Journal of biomechanics
pub_type： 杂志文章
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abstract：:As humans walk or run, external (environmental) and internal (physiological) disturbances induce variability. How humans regulate this variability from stride-to-stride can be critical to maintaining balance. One cannot infer what is "controlled" based on analyses of variability alone. Assessing control requires quant...
journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(89)90019-5
更新日期：1989-01-01 00:00:00
abstract：:Although arterio-venous grafts (AVGs) represent the second choice as permanent vascular access for hemodialysis, this solution is still affected by a relevant failure rate due to graft thrombosis, and development of neointimal hyperplasia (IH) at the distal vein. As a key role in these processes has been attributed to...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.109591
更新日期：2020-02-13 00:00:00
abstract：:Mechnotransduction, the phenomenon by which cells respond to applied force, is necessary for normal cell processes and is implicated in the pathology of several diseases including atherosclerosis. The exact mechanisms which govern how forces can affect gene expression have not been determined, but putative direct forc...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.08.024
更新日期：2008-11-14 00:00:00
abstract：:A new software tool to assign the material properties of bone to an ABAQUS finite element mesh was created and compared with Bonemat, a similar tool originally designed to work with Ansys finite element models. Our software tool (py_bonemat_abaqus) was written in Python, which is the chosen scripting language for ABAQ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.07.037
更新日期：2016-09-06 00:00:00
abstract：:The aim of cryosurgery is to kill cells within a closely defined region maintained at a predetermined low temperature. To effectively kill cells, it is important to be able to predict and control the cooling rate over some critical range of temperatures and freezing states in order to regulate the spatial extent of in...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.11.005
更新日期：2007-01-01 00:00:00
abstract：:The hypothesis that control of lumbar spinal muscle synergies is biomechanically optimized was studied by comparing EMG data with an analytical model with a multi-component cost function that could include (1) trunk displacements, (2) intervertebral displacements, (3) intervertebral forces; (4) sum of cubed muscle str...
journal_title：Journal of biomechanics
pub_type： 杂志文章
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abstract：:Current motion capture techniques all have shortcomings when applied to the 3D quantitative evaluation of thumb base motion. Dynamic CT might overcome these shortcomings but, so far, robustness of this technique in more than one specimen has not yet been demonstrated. The aim of the current study is to further evaluat...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.05.008
更新日期：2016-06-14 00:00:00
abstract：:Lower propulsive joint powers, particularly at the ankle, are often observed in older compared to young adults. Interventions to increase joint powers often require labs with motion capture and force treadmill technology. Translating these interventions out of the lab requires identifying portable measures that track ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109821
更新日期：2020-06-09 00:00:00
abstract：:Parallel to the massive use of image-based computational hemodynamics to study the complex flow establishing in the human aorta, the need for suitable experimental techniques and ad hoc cases for the validation and benchmarking of numerical codes has grown more and more. Here we present a study where the 3D pulsatile ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.06.017
更新日期：2014-09-22 00:00:00
