Abstract：
:Progress in medicine and higher expectation of quality of life has led to a higher demand for several dental and medical treatments. This increases the occurrence of situations in which orthodontic treatment is complicated by pathological conditions, medical therapies and drugs. Together with experiments, computer models might lead to a better understanding of the effect of pathologies and medical treatment on tooth movement. This study uses a previously presented mechanobiological model of orthodontic tooth displacement to investigate the effect of pathologies and (medical) therapies on the result of orthodontic treatment by means of three clinically relevant case studies looking at the effect of estrogen deficiency, the effect of OPG injections and the influence of fluoride intake. When less estrogen was available, the model predicted bone loss and a rise in the number of osteoclasts present at the compression side, and a faster bone resorption. These effects were also observed experimentally. Experiments disagreed on the effect of estrogen deficiency on bone formation, while the mechanobiological model predicted very little difference between the pathological and the non-pathological case at formation sites. The model predicted a decrease in tooth movement after OPG injections or fluoride intake, which was also observed in experiments. Although more experiments and model analysis is needed to quantitatively validate the mechanobiological model used in this study, its ability to conceptually describe several pathological conditions is an important measure for its validity.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Van Schepdael A,Vander Sloten J,Geris Ldoi
10.1016/j.jbiomech.2012.10.037subject
Has Abstractpub_date
2013-02-01 00:00:00pages
470-7issue
3eissn
0021-9290issn
1873-2380pii
S0021-9290(12)00644-6journal_volume
46pub_type
杂志文章abstract：:This study examined the influence of a mechanical perturbation of the ankle joint on obstacle avoidance pattern. A decoupled control between the distal joint and the combined (hip-knee) proximal joints was observed according to the task requirement. In this context, a greater mechanical friction at the ankle should be...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2004.07.019
更新日期：2005-07-01 00:00:00
abstract：:Medical professionals, physical therapists, product designers, and computational models all use cervical spine range of motion reference values. To support these functions, researchers have collected a plethora of data to determine the normal range of motion of the cervical spine of adult subjects. However, little to ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.06.021
更新日期：2008-08-28 00:00:00
abstract：:Hamstring muscle strain injury is one of the most common injuries in sports involving sprinting and kicking. Studies examining hamstring kinematics and activations are rich for sprinting but lacking for kicking. The purpose of this study was to examine kinematics and activations of hamstring muscles in instep and cut-...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.109482
更新日期：2020-01-23 00:00:00
abstract：:We have developed a laser-aligned measuring device to facilitate the measurement of linear hand dimensions. Our objective has been to make a simple, clinically applicable device for anthropometry of the hands in patients with arthritis in order to gauge the progression of hand deformities. The system provides an alter...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(03)00121-0
更新日期：2003-09-01 00:00:00
abstract：:Whole body vibration (WBV) is a promising tool for counteracting bone loss. Most WBV studies on animals have been performed at acceleration <1g and frequency between 30 and 90Hz. Such WBV conditions trigger bone growth in osteopenia models, but not in healthy animals. In order to test the ability of WBV to promote ost...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.04.031
更新日期：2016-06-14 00:00:00
abstract：:The present article investigates the influence of center-of-mass movements on the variation of the structure in human postural sway. Twelve healthy younger persons performed 60s quiet standing, 60s relaxed standing, and 10 min relaxed standing on two force plates. Center-of-pressure (CoP) and gravitational line (GL) p...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2012.10.016
更新日期：2013-02-01 00:00:00
abstract：:Cellular mechanics is known to play an important role in many cellular functions including adhesion, migration, proliferation, and differentiation. Human mesenchymal stem cells (hMSCs) demonstrate unique mechanical properties distinct from fully differentiated cells. This observation suggests that the stem cell mechan...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.07.024
更新日期：2011-10-13 00:00:00
abstract：:The successful development of early-stage cartilage and meniscus repair interventions in the knee requires biomechanical and biotribological understanding of the design of the therapeutic interventions and their tribological function in the natural joint. The aim of this study was to develop and validate a porcine kne...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.07.043
更新日期：2015-09-18 00:00:00
abstract：:Stair negotiation is among the most challenging and hazardous types of locomotion for older people. However, the effect of aging on balance control during stair negotiation has not been investigated. Instantaneous inclination angles between the center of mass (CoM) and center of pressure (CoP) have been reported to de...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.11.001
更新日期：2007-01-01 00:00:00
abstract：:Progression and rupture of atherosclerotic plaques in coronary and carotid arteries are the key processes underlying myocardial infarctions and strokes. Biomechanical stress analyses to compute mechanical stresses in a plaque can potentially be used to assess plaque vulnerability. The stress analyses strongly rely on ...
journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
doi：10.1016/j.jbiomech.2014.01.019
更新日期：2014-03-03 00:00:00
abstract：:Age-related changes in bone quality are mainly manifested in the reduced toughness. Since the post-yield deformation of bone is realized through microdamage formation (e.g., microcracking and diffuse damage), it is necessary to understand the mechanism of microdamage formation in bone in order to elucidate underlying ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.01.009
更新日期：2006-01-01 00:00:00
abstract：:A reflection ultrasonic technique, which offers several advantages over transmission ultrasonic techniques, has been described for elastic property measurement of bone. Ultrasonic velocities from specimens of cancellous bone were compared using a reflection ultrasound technique and the more traditional transmission ul...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)90061-2
更新日期：1994-09-01 00:00:00
abstract：:Experimental evidence demonstrates that collagen cross-linking in bone tissue significantly influences its deformation and failure behavior yet difficulties exist in determining the independent biomechanical effects of collagen cross-linking using in vitro and in vivo experiments. The aim of this study is to use a nan...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.02.017
更新日期：2008-01-01 00:00:00
abstract：:Shorter generation time and the power of genetic manipulation make mice an ideal model system to study bone biology as well as bone diseases. However their small size presents a challenge to perform strength measurements, particularly of the weight-bearing cancellous bone in the murine long bones. We recently develope...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.02.040
更新日期：2016-05-03 00:00:00
abstract：:Propulsive forces generated by swimmers hand/forearm, have been studied through experimental tests. However, there are serious doubts as to whether forces quantified in this way are accurate enough to be meaningful. In order to solve some experimental problems, some numerical techniques have been proposed using Comput...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.03.012
更新日期：2006-01-01 00:00:00
abstract：:This study investigated the center of rotation (COR) of the intervertebral segments of the lower lumbar spine (L4-L5 and L5-S1 segments) in sagittal plane during a weight-lifting (3.6 kg in each hand) extension activity performed with the pelvis constrained. Seven healthy subjects were studied using a dual fluoroscopi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.12.029
更新日期：2016-02-08 00:00:00
abstract：:Knee kinetic asymmetries are present during jump-landings in athletes returning to sport following anterior cruciate ligament (ACL) reconstruction, and are associated with an increased risk for sustaining a second ACL injury. The loadsol® is a wireless load sensing insole that can be used in non-laboratory settings. T...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.07.037
更新日期：2019-10-11 00:00:00
abstract：:Exercise is one of the few effective treatments for LBP. Although exercise is often based on the premise of reduced spinal stiffness, trunk muscle adaptation may increase stiffness. This study developed and validated a method to assess trunk stiffness and damping, and tested these parameters in 14 people with recurrin...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.10.001
更新日期：2009-01-05 00:00:00
abstract：:In posturographic recordings, the center of pressure (COP) displacement does not accurately reflect migration of the gravity line (GL), the vertical line passing through the body's center of gravity, COG. Since the horizontal ground reaction force, Fx, is proportional to the horizontal acceleration of the COG its seco...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(97)00116-4
更新日期：1998-02-01 00:00:00
abstract：:The effects and interaction of the anatomical displacements in the human knee are a prerequisite to an accurate assessment and communication of the kinematic data. For the kinematic information to be used to improve diagnosis and treatment, and for better prosthetic design and installation, there must be clear, concis...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(90)90378-g
更新日期：1990-01-01 00:00:00
abstract：:Humans maintain upright bipedal posture by producing appropriate force against the environment through the interaction of neural controlled muscle force with the mechanics of the skeletal system. Characterizing these mechanics facilitates understanding of the neural control. We used a mechanical model of an upright hu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.03.018
更新日期：2012-06-01 00:00:00
abstract：:Histological investigation along with finite element analysis of arterial wall/atherosclerotic plaque geometries indicates the paradoxical result that ruptures often occur at sites with predicted stresses of half the plaque cap strength. Recent experiments have revealed calcified cells within the cap suggesting that t...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.06.012
更新日期：2010-10-19 00:00:00
abstract：:Here we present a study on the impact of assumptions on image-based hemodynamic simulations of healthy carotid bifurcations. In particular, we evaluate to which extent assumptions on blood rheology influence bulk flow features, driven by the fact that few studies have provided adequate insights into the influence of a...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.06.028
更新日期：2011-09-02 00:00:00
abstract：:Among the most common causes of upper extremity fracture is a fall on the outstretched hand. Yet few data exist on the biomechanical factors which affect injury risk during this event. In this study, we measured impact forces during low-height (0-5 cm), forward falls onto the outstretched hand, and found that these ar...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(98)00137-7
更新日期：1998-12-01 00:00:00
abstract：:This paper addresses the question of whether maximal vertical jump height depends on initial jumping posture. A direct dynamics computer simulation approach was used to avoid subject preference and practice effects. The human body was modeled as four rigid segments connected by ideal hinge joints, with movement constr...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(96)00030-9
更新日期：1996-09-01 00:00:00
abstract：:Accurate knowledge of extraocular muscle (EOM) tension is important for the diagnosis of and surgical planning for strabismus, such as choosing which eye to operate or determining the amount of muscle displacement. Previous evaluations of passive EOM tension have relied extensively on the experience and skill of ophth...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109955
更新日期：2020-08-26 00:00:00
abstract：:The performance criterion in maximum vertical jumping has typically been assumed to simply raise the center of mass as high as possible. In many sporting activities minimizing movement time during the jump is likely also critical to successful performance. The purpose of this study was to examine maximum height jumps ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.04.021
更新日期：2015-08-20 00:00:00
abstract：:This study examined the effect of friction between the hand and grip surface on a person's grip strategy and force generation capacity. Twelve young healthy adults performed power grip exertions on an instrumented vertical cylinder with the maximum and 50% of maximum efforts (far above the grip force required to hold ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.03.020
更新日期：2011-05-17 00:00:00
abstract：:Chemically defined serum-free medium has been shown to better maintain the mechanical integrity of articular cartilage explants than serum-supplemented medium during long-term in vitro culture, but little is known about its effect on cellular mechanisms. We hypothesized that the chemically defined culture medium could...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.02.005
更新日期：2015-04-13 00:00:00
abstract：:A technique is introduced for simultaneous measurements of the heel pad tissue deformation and the heel-ground contact stresses developing during the stance phase of gait. Subjects walked upon a gait platform integrating the contact pressure display optical method for plantar pressure measurements and a digital radiog...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(01)00143-9
更新日期：2001-12-01 00:00:00
