Spironolactone blocks Epstein-Barr virus production by inhibiting EBV SM protein function.

abstract：:Herpes simplex virus type 1 (HSV-1) thymidine kinase is currently used as a suicide agent in the gene therapy of cancer. This therapy is based on the preferential phosphorylation of nucleoside analogs by tumor cells expressing HSV-1 thymidine kinase. However, the use of HSV-1 thymidine kinase is limited in part by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Black ME,Newcomb TG,Wilson HM,Loeb LA

更新日期：1996-04-16 00:00:00

abstract：:Selected aspects of the evolutionary process and more specifically of the genetic variation are considered, with an emphasis in studies performed by my group. One key aspect of evolution seems to be the concomitant occurrence of dichotomic, contradictory (dialect) processes. Genetic variation is structured, and the dy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salzano FM

更新日期：2000-05-09 00:00:00

abstract：:Cognitive flexibility depends on a fast neural learning mechanism for enhancing momentary relevant over irrelevant information. A possible neural mechanism realizing this enhancement uses fast spiking interneurons (FSIs) in the striatum to train striatal projection neurons to gate relevant and suppress distracting cor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banaie Boroujeni K,Oemisch M,Hassani SA,Womelsdorf T

更新日期：2020-07-28 00:00:00

abstract：:Human telomeres terminate with a single-stranded 3' G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray S,Bandaria JN,Qureshi MH,Yildiz A,Balci H

更新日期：2014-02-25 00:00:00

abstract：:We showed previously that rrn P1 promoters require unusually high concentrations of the initiating nucleoside triphosphates (ATP or GTP, depending on the promoter) for maximal transcription in vitro. We proposed that this requirement for high initiating NTP concentrations contributes to control of the rrn P1 promoters...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider DA,Gaal T,Gourse RL

更新日期：2002-06-25 00:00:00

abstract：:DNA vaccines, comprised of plasmid DNA encoding proteins from pathogens, allergens, and tumors, are being evaluated as prophylactic vaccines and therapeutic treatments for infectious diseases, allergies, and cancer; plasmids encoding normal human proteins are likewise being tested as vaccines and treatments for autoim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu M,Acres B,Balloul JM,Bizouarne N,Paul S,Slos P,Squiban P

更新日期：2004-10-05 00:00:00

abstract：:Repetitive brain stimulation protocols induce plasticity in the stimulated site in brain slice models. Recent evidence from network models has indicated that additional plasticity-related changes occur in nonstimulated remote regions. Despite increasing use of brain stimulation protocols in experimental and clinical s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abe M,Fukuyama H,Mima T

更新日期：2014-03-25 00:00:00

abstract：:The interaction of carboxylate ions (acetate, butyrate) with nucleic aicd bases and nucleosides has been investigated by proton magnetic resonance in dimethyl sulfoxide (d6)/H2O mixtures. Carboxylate ions interacted only with guanine derivatives and led to a large downfield shift of the NH2 resonance. A 1:1 stoichiome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lancelot G,Hélène C

更新日期：1977-11-01 00:00:00

abstract：:The amino-acid sequence of the gamma-carboxyglutamic acid-containing protein of bovine bone is presented. The sequence of 43 of the 49 residues was determined automatically on the intact protein and on a tryptic peptide. The remainder was determined by conventional procedures on tryptic and chymotrytic peptides. Resid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price PA,Poser JW,Raman N

更新日期：1976-10-01 00:00:00

abstract：:The molecular mechanism of desensitization of soluble guanylyl cyclase (sGC), the NO receptor, has long remained unresolved. Posttranslational modification and redox state have been postulated to affect sGC sensitivity to NO but evidence has been lacking. We now show that sGC can be S-nitrosylated in primary aortic sm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sayed N,Baskaran P,Ma X,van den Akker F,Beuve A

更新日期：2007-07-24 00:00:00

abstract：:The amyloid beta-protein precursor (AbetaPP) is best known as the parent molecule to the amyloid beta-peptide that accumulates in the brains of patients with Alzheimer's disease. Secreted isoforms of AbetaPP that contain the Kunitz proteinase inhibitor domain are analogous to the previously identified cell-secreted pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu F,Davis J,Miao J,Previti ML,Romanov G,Ziegler K,Van Nostrand WE

更新日期：2005-12-13 00:00:00

abstract：:Selective inhibition of the intrinsic coagulation pathway is a promising strategy for developing safer anticoagulants that do not cause serious bleeding. Intrinsic tenase, the final and rate-limiting enzyme complex in the intrinsic coagulation pathway, is an attractive but less explored target for anticoagulants due t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao L,Wu M,Xiao C,Yang L,Zhou L,Gao N,Li Z,Chen J,Chen J,Liu J,Qin H,Zhao J

更新日期：2015-07-07 00:00:00

abstract：:We have shown that a scanning transmission electron microscope with a high brightness field emission source is capable of obtaining better than 3 A resolution using 30 to 40 keV electrons. Elastic dark field images of single atoms of uranium and mercury are shown which demonstrate this fact as determined by a modified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall J,Langmore J,Isaacson M,Crewe AV

更新日期：1974-01-01 00:00:00

abstract：:A single, modified nucleoside in Escherichia coli tRNA, 6-(3-methyl-2-butenylamino)-2-methyl-thio-9-beta-D-ribofuranosylpurine, has been desulfurized with Raney nickel to afford its probable biosynthetic precursor. The limitations of the reaction at the nucleoside and tRNA levels and its lack of inhibition of the amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hecht SM,Kirkegaard LH,Bock RM

更新日期：1971-01-01 00:00:00

abstract：:The nit-2 major nitrogen regulatory gene of Neurospora crassa turns on the expression of various unlinked structural genes that specify nitrogen-catabolic enzymes under nitrogen-limitation conditions. The nit-2 gene encodes a protein of 1036 amino acid residues with a single zinc finger and a downstream basic region t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu YH,Marzluf GA

更新日期：1990-07-01 00:00:00

abstract：:Equity is of fundamental concern in the quest for international cooperation to stabilize greenhouse gas concentrations by the reduction of emissions. By modeling the carbon cycle, we estimate the global CO(2) emissions that would be required to stabilize the atmospheric concentration of CO(2) at levels ranging from 45...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolin B,Kheshgi HS

更新日期：2001-04-24 00:00:00

abstract：:A protein that specifically binds leukemia inhibitory factor (LIF) has been isolated from normal mouse serum by using four successive fractionation steps: chromatography on a LIF affinity matrix, anion-exchange chromatography, size-exclusion chromatography, and preparative native gel electrophoresis. The purified LIF-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Layton MJ,Cross BA,Metcalf D,Ward LD,Simpson RJ,Nicola NA

更新日期：1992-09-15 00:00:00

abstract：:The fifth exons of major histocompatibility complex (MHC) class I genes encode a transmembrane domain (TM) that is largely responsible for class I antigen cell-surface expression usually through conventional hydrophobic amino acid-membrane interactions or, less often, through phosphatidylinositol linkage. In this repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crew MD,Filipowsky ME,Neshat MS,Smith GS,Walford RL

更新日期：1991-06-01 00:00:00

abstract：:Nanoparticle-based experimental therapeutics are currently being investigated in numerous human clinical trials. CALAA-01 is a targeted, polymer-based nanoparticle containing small interfering RNA (siRNA) and, to our knowledge, was the first RNA interference (RNAi)-based, experimental therapeutic to be administered to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuckerman JE,Gritli I,Tolcher A,Heidel JD,Lim D,Morgan R,Chmielowski B,Ribas A,Davis ME,Yen Y

更新日期：2014-08-05 00:00:00

abstract：:The protease encoded by the human immunodeficiency virus (HIV) processes the viral gag and gag-pol protein precursor by posttranslational cleavage. In this study we have demonstrated by site-specific mutagenesis (Asp----Thr) and by pepstatin A inhibition that the recombinant HIV protease is an aspartic-type protease. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seelmeier S,Schmidt H,Turk V,von der Helm K

更新日期：1988-09-01 00:00:00

abstract：:IDIOTYPY HAS BEEN STUDIED IN ANTIBODIES AGAINST A PROTEIN ANTIGEN: hen ovalbumin. Various fractions of antisera to hen ovalbumin have been compared from the standpoint of the idiotypic specificities found on the immunoglobulins that they contain. Idiotypic specificities were found to be common to (a) antibodies that w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oudin J,Cazenave PA

更新日期：1971-10-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) have a unique capacity to undergo self-renewal and multi-lineage differentiation to provide a lifetime supply of mature blood cells. By using conditional knockout technology, we disrupted the c-myb proto-oncogene specifically in adult bone marrow (BM) to demonstrate that this transcript...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lieu YK,Reddy EP

更新日期：2009-12-22 00:00:00

abstract：:We and other groups have recently reported the potentiation by ribonucleotide reductase inhibitors such as hydroxyurea of the anti-human immunodeficiency virus type 1 (HIV-1) activity of purine and pyrimidine 2',3'-dideoxynucleosides in both resting and phytohemagglutinin-stimulated peripheral blood mononuclear cells....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao WY,Johns DG,Chokekuchai S,Mitsuya H

更新日期：1995-08-29 00:00:00

abstract：:The extensive Early Jurassic continental strata of southern Africa have yielded an exceptional record of dinosaurs that includes scores of partial to complete skeletons of the sauropodomorph Massospondylus, ranging from embryos to large adults. In 1976 an incomplete egg clutch including in ovo embryos of this dinosaur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reisz RR,Evans DC,Roberts EM,Sues HD,Yates AM

更新日期：2012-02-14 00:00:00

abstract：:The extinction of a species is inevitably preceded by the extirpation of a series of local populations. Ecological theory predicts that vulnerability to extirpation varies between populations and is ultimately linked to environmental heterogeneity. If populations of a species are present in multiple regions separated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yackulic CB,Sanderson EW,Uriarte M

更新日期：2011-03-08 00:00:00

abstract：:Oligosaccharide moieties of cell-surface glycoconjugates are thought to be involved in recognition events associated with tumor metastasis and invasion. Using swainsonine (SW), an inhibitor of Golgi alpha-mannosidase II that results in the formation of hybrid-type oligosaccharides on N-linked glycoproteins, we have te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Humphries MJ,Matsumoto K,White SL,Olden K

更新日期：1986-03-01 00:00:00

abstract：:YC-1 [3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole] is an allosteric activator of soluble guanylyl cyclase (sGC). YC-1 increases the catalytic rate of the enzyme and sensitizes the enzyme toward its gaseous activators nitric oxide or carbon monoxide. In other studies the administration of YC-1 to experimental animal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin E,Lee YC,Murad F

更新日期：2001-11-06 00:00:00

abstract：:Efficient expression of human T-cell leukemia virus type I (HTLV-I) genes requires both host and viral proteins and is dependent on DNA sequences in the proviral long terminal repeats (LTRs). We have used DNase I-protection assays (footprinting) to construct a map of protein-DNA interactions over a 250-nucleotide regi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nyborg JK,Dynan WS,Chen IS,Wachsman W

更新日期：1988-03-01 00:00:00

abstract：:The mouse sperm receptor, a glycoprotein called ZP3, is synthesized and secreted by growing oocytes. It is present in more than a billion copies in the unfertilized egg's extracellular coat, or zona pellucida. We have cloned and characterized a region of the mouse (CD-1) genome that spans 10 kilobases of the ZP3 locus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinloch RA,Roller RJ,Fimiani CM,Wassarman DA,Wassarman PM

更新日期：1988-09-01 00:00:00

abstract：:Replication of complementary-strand DNA in filamentous phages is initiated by a primer RNA that is synthesized at the minus-strand origin on the viral single-stranded DNA by Escherichia coli RNA polymerase holoenzyme containing the sigma70 subunit. We have demonstrated that the affinity of RNA polymerase in vitro to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higashitani A,Higashitani N,Horiuchi K

更新日期：1997-04-01 00:00:00