Primary structure of the mouse sperm receptor polypeptide determined by genomic cloning.

Abstract:

:The mouse sperm receptor, a glycoprotein called ZP3, is synthesized and secreted by growing oocytes. It is present in more than a billion copies in the unfertilized egg's extracellular coat, or zona pellucida. We have cloned and characterized a region of the mouse (CD-1) genome that spans 10 kilobases of the ZP3 locus. The genomic clones described encompass the entire ZP3 coding region, which contains eight exons. The exons were identified, mapped, and sequenced, yielding the entire primary structure of the ZP3 polypeptide chain (424 amino acids; Mr, 46,300), which includes a 22-amino acid signal sequence. In addition, sequencing of genomic clones has revealed some unusual features of ZP3 mRNA and a region just downstream of the ZP3 gene.

authors

Kinloch RA,Roller RJ,Fimiani CM,Wassarman DA,Wassarman PM

doi

10.1073/pnas.85.17.6409

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

6409-13

issue

17

eissn

0027-8424

issn

1091-6490

journal_volume

85

pub_type

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