Abstract：
:Ultrasound-assisted synthesis of benzimidazo[2,1-b]quinazolin-1(1H)-ones was achieved via piperidine-catalyzed three-component reaction of 2-aminobenzimidazoles, an aromatic aldehyde, and 1,3-dione in aqueous isopropanol. This mechanism was first suspected following our identification of unusual reaction intermediates in a one-pot reaction. An unprecedented coupling reaction, it involved a nucleophilic attack by 2-aminobenzimidazole on in situ generated Michael adduct, followed by electrocyclic ring formation reaction. In contrast to the commonly accepted mechanism, that the direct reaction of 2-amino benzimidazole with a Knoevenagel adduct cannot deliver target compounds.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Chen LH,Chung TW,Narhe BD,Sun CMdoi
10.1021/acscombsci.5b00186subject
Has Abstractpub_date
2016-03-14 00:00:00pages
162-9issue
3eissn
2156-8952issn
2156-8944journal_volume
18pub_type
杂志文章abstract：:An efficient discovery strategy by combining diversity-oriented synthesis and converging cellular screening is described. By a three-round screening process, we identified novel tricyclic pyrido[2,3-b][1,4]benzothiazepines showing potent inhibitory activity against paclitaxel-resistant cell line H460TaxR (EC50 < 1.0 μ...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.6b00010
更新日期：2016-05-09 00:00:00
abstract：:The thin film system Ti-Ni-Si was investigated using methods of combinatorial materials science. A thin film composition spread library of the system was fabricated using combinatorial magnetron sputtering. The functional properties Seebeck coefficient, electrical resistivity, and luminance were determined using high-...
journal_title：ACS combinatorial science
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abstract：:Retinoic acid (RA) is a key metabolite necessary for embryonic development and differentiation in vertebrates. We demonstrate the utility of genetically encoded, ligand-activatable single-chain bioluminescence probes for detecting RAs from different biological sources. We examined 13 different molecular designs to ide...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.9b00035
更新日期：2019-06-10 00:00:00
abstract：:Competition-enhanced ligand screening (CompELS) was employed to rapidly screen through large DNA libraries to identify single-stranded, oligonucleotide-based ligands called aptamers that bind to a nonbiological target. This previously unreported aptamer screening approach involves the repeated introduction of unenrich...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.8b00048
更新日期：2018-10-08 00:00:00
abstract：:In this article, an original one-pot method is utilized to synthesize a variety of derivatives of naphtho[2,1-b]furan-2(1H)-one via a pseudo-four-component domino reaction of aryl aldehydes, acetic anhydride, hippuric acids, and 2-naphthols catalyzed by HSW@SPIONs. This reaction illustrates an array of attractive feat...
journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2015-08-10 00:00:00
abstract：:The exploration of new alloys with desirable properties has been a long-standing challenge in materials science because of the complex relationship between composition and microstructure. In this Research Article, we demonstrate a combinatorial strategy for the exploration of composition dependence of microstructure. ...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.6b00040
更新日期：2016-10-10 00:00:00
abstract：:Solid-phase synthetic strategies toward the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a one-pot, microwave-assisted, ruthenium-catalyzed cross-metathesis and reduction to obtain Csp3-Csp3...
journal_title：ACS combinatorial science
pub_type： 杂志文章
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.6b00041
更新日期：2016-07-11 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2014-10-13 00:00:00
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journal_title：ACS combinatorial science
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更新日期：2014-12-08 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2012-08-13 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2018-03-12 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2017-02-13 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2017-07-10 00:00:00
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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更新日期：2014-11-10 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2013-01-14 00:00:00
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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doi：10.1021/co200070m
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journal_title：ACS combinatorial science
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更新日期：2020-12-14 00:00:00
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.0c00174
更新日期：2020-12-14 00:00:00
