Abstract:
:Dispiro-pyrrolidino/pyrrolizidino fused oxindoles/acenaphthoquinones have been derived from andrographolide via azomethine ylide cycloaddition to the conjugated double-bond under microwave (MW) irradiation. The reactions are chemo-, stereo-, and regioselective in nature. Change in amino acid from sarcosine/N-benzyl glycine to l-proline changes the regiochemistry. A representative library of 40 compounds along with in vitro anticancer evaluation is reported.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Hazra A,Bharitkar YP,Chakraborty D,Mondal SK,Singal N,Mondal S,Maity A,Paira R,Banerjee S,Mondal NBdoi
10.1021/co3001154subject
Has Abstractpub_date
2013-01-14 00:00:00pages
41-8issue
1eissn
2156-8952issn
2156-8944journal_volume
15pub_type
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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abstract::DNA-encoded synthesis is rekindling interest in combinatorial compound libraries for drug discovery and in technology for automated and quantitative library screening. Here, we disclose a microfluidic circuit that enables functional screens of DNA-encoded compound beads. The device carries out library bead distributio...
journal_title:ACS combinatorial science
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abstract::Solid-phase synthetic strategies toward the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a one-pot, microwave-assisted, ruthenium-catalyzed cross-metathesis and reduction to obtain Csp3-Csp3...
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journal_title:ACS combinatorial science
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