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High throughput synthesis of extended pyrazolo[3,4-d]dihydropyrimidines.

Abstract：

:Thirteen 5-hetarylaminopyrazoles were synthesized in 62-93% yield through the arylation of 1-isopropyl- and 1-phenyl-5-aminopyrazoles with electrophilic hetarylhalides under optimized conditions. Condensation of 5-hetarylaminopyrazoles with carbonyl compounds facilitated by AcOH or Me(3)SiCl furnished 23 pyrazolo[3,4-d]dihydropyrimidines in 69-86% yield. The target compounds were isolated through simple crystallization. The scope and limitation of the method are discussed.

journal_name

ACS Comb Sci

journal_title

ACS combinatorial science

authors

Ryabukhin SV,Granat DS,Plaskon AS,Shivanyuk AN,Tolmachev AA,Volovenko YM

doi

10.1021/co300063x

subject

Has Abstract

pub_date

2012-08-13 00:00:00

pages

465-70

issue

8

eissn

2156-8952

issn

2156-8944

journal_volume

14

pub_type

杂志文章

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