Abstract:
:A build/couple/pair (B/C/P) strategy was employed to generate a library of 7936 stereochemically diverse 12-membered macrolactams. All 8 stereoisomers of a common linear amine precursor were elaborated to form the corresponding 8 stereoisomers of two regioisomeric macrocyclic scaffolds via head-to-tail cyclization. Subsequently, these 16 scaffolds were further diversified via capping of two amine functionalities on SynPhase Lanterns. Reagents used for solid-phase diversification were selected using a sparse matrix design strategy with the aim of maximizing coverage of chemical space while adhering to a preset range of physicochemical properties.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Fitzgerald ME,Mulrooney CA,Duvall JR,Wei J,Suh BC,Akella LB,Vrcic A,Marcaurelle LAdoi
10.1021/co200161zsubject
Has Abstractpub_date
2012-02-13 00:00:00pages
89-96issue
2eissn
2156-8952issn
2156-8944journal_volume
14pub_type
杂志文章abstract::Metal-organic frameworks (MOFs) are nanoporous materials with exceptional host-guest properties poised for groundbreaking innovations in gas separation applications according to high-throughput (HT) screening data. However, MOF structural libraries are nearly infinite in practice and so statistical and information tec...
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abstract::The diversity oriented synthesis of substituted pyridines and dihydro-6H-quinolin-5-ones tethered with aryls and heteroaryls was achieved in very good yields through CeCl(3)·7H(2)O-NaI catalyst via variants of the Bohlmann-Rahtz reaction. β-Enaminones derived from various aryl and heteroaryl methyl ketones were regios...
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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journal_title:ACS combinatorial science
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更新日期:2020-12-14 00:00:00