Abstract:
:The reactions of vinyl malononitriles with 3-phenacylideneoxindoles in ethanol in the presence of DBU as base resulted in the functionalized spirocyclic oxindoles through the domino Michael addition and intramolecular nucleophilic addition to cyano group. On the other hand, the similar reaction in the presence of piperidine as base afforded the simple Michael addition products in good yields. The stereochemistry of the spirooxindoles was established with (1)H NMR data and single crystal structures.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Xie YJ,Sun J,Yan CGdoi
10.1021/co500006csubject
Has Abstractpub_date
2014-06-09 00:00:00pages
271-80issue
6eissn
2156-8952issn
2156-8944journal_volume
16pub_type
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journal_title:ACS combinatorial science
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