Abstract:
:Unfunctionalized alkylbiphenyls were fabricated by a parallel and combinatorial synthesis using pentaerythritol as a tetrapodal soluble support for a sulfonate-based traceless multifunctional linker system. Nickel N-heterocyclic carbene-catalyzed reactions of pentaerythritol tetrakis(biphenylsulfonate)s with primary alkylmagnesium bromides generated the alkylbiphenyl derivatives by desulfitative cleavage/cross-coupling of the C-S bond without any "memory" of the attachment on the support. Though the reactions were completed with sufficient yields in 12 h at room temperature, even with only 1.5 equiv of nucleophiles, they still retained the benefits of facile isolation observed in polymer-supported reactions.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Kim WK,Jang JH,Jo H,Park Kdoi
10.1021/co400136ksubject
Has Abstractpub_date
2014-05-12 00:00:00pages
225-31issue
5eissn
2156-8952issn
2156-8944journal_volume
16pub_type
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