Parallel and combinatorial liquid-phase synthesis of alkylbiphenyls using pentaerythritol support.

Abstract:

:Unfunctionalized alkylbiphenyls were fabricated by a parallel and combinatorial synthesis using pentaerythritol as a tetrapodal soluble support for a sulfonate-based traceless multifunctional linker system. Nickel N-heterocyclic carbene-catalyzed reactions of pentaerythritol tetrakis(biphenylsulfonate)s with primary alkylmagnesium bromides generated the alkylbiphenyl derivatives by desulfitative cleavage/cross-coupling of the C-S bond without any "memory" of the attachment on the support. Though the reactions were completed with sufficient yields in 12 h at room temperature, even with only 1.5 equiv of nucleophiles, they still retained the benefits of facile isolation observed in polymer-supported reactions.

journal_name

ACS Comb Sci

authors

Kim WK,Jang JH,Jo H,Park K

doi

10.1021/co400136k

subject

Has Abstract

pub_date

2014-05-12 00:00:00

pages

225-31

issue

5

eissn

2156-8952

issn

2156-8944

journal_volume

16

pub_type

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