Abstract:
:An efficient method is described for the solid-supported synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines from 2,4-dichloro-3-nitropyridine. The key pyridine building block was reacted with polymer-supported amines, followed by replacement of the second chlorine with amines, nitro group reduction, and imidazole ring closure with aldehydes. Depending on the combination of polymer-supported and solution-phase reagents, the strategy allowed for the simple preparation of the target trisubstituted derivatives with variable positioning of the pyridine nitrogen atom. Additionally, after a slight modification of the method, the preparation of strictly isomeric imidazopyridines was possible.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Lemrová B,Smyslová P,Popa I,Oždian T,Zajdel P,Soural Mdoi
10.1021/co500090tsubject
Has Abstractpub_date
2014-10-13 00:00:00pages
558-65issue
10eissn
2156-8952issn
2156-8944journal_volume
16pub_type
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