Abstract：
:A one-pot, three-component synthesis of benzimidazole-linked thiazolidines from 2-cyanomethyl benzimidazole, iso-, isothio-, or isoselenocyanates and 1,2-dichloroethane is reported. Isolation of the key intermediate formed during the course of the reaction validates its mechanistic pathway. Under the same reaction conditions, benzimidazole-linked/fused thiazinanes were obtained when 1,3-dichloropropane or diiodomethane was used.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Lu HY,Barve IJ,Selvaraju M,Sun CMdoi
10.1021/acscombsci.9b00161subject
Has Abstractpub_date
2020-01-13 00:00:00pages
42-48issue
1eissn
2156-8952issn
2156-8944journal_volume
22pub_type
杂志文章abstract：:In this article, an original one-pot method is utilized to synthesize a variety of derivatives of naphtho[2,1-b]furan-2(1H)-one via a pseudo-four-component domino reaction of aryl aldehydes, acetic anhydride, hippuric acids, and 2-naphthols catalyzed by HSW@SPIONs. This reaction illustrates an array of attractive feat...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.5b00018
更新日期：2015-08-10 00:00:00
abstract：:The extracellular-related kinase 5 (ERK5) is a promising target for cancer therapy. A high-throughput screen was developed for ERK5, based on the IMAP FP progressive binding system, and used to identify hits from a library of 57 617 compounds. Four distinct chemical series were evident within the screening hits. Resyn...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.5b00155
更新日期：2016-08-08 00:00:00
abstract：:Parallel solution-phase synthesis of combinatorial libraries of dihydroindenoisoquinolines employing a sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol was realized. The scope and limitations of the protocol with respect to the substitution pattern in the aryl ring of the indene core, a...
journal_title：ACS combinatorial science
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abstract：:An unprecedented three-component C(sp(3))-H functionalization of 2-alkylazaarenes with aryl aldehydes and 4-hydroxycoumarins was realized, providing azaarene-substituted 3-benzyl-4-hydroxycoumarins in good to excellent yields. These new target compounds displayed broad-spectrum antibacterial activities, providing a ne...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.6b00082
更新日期：2016-09-12 00:00:00
abstract：:An expedient and metal-free synthetic protocol for construction of substituted quinolines has been developed from anilines and phenylacetaldehydes using imidazolium cation-based ionic liquids as the reaction medium. Mechanistic analysis indicated that the reaction occurs through C-C and C-N bond formation to produce i...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/co500047w
更新日期：2014-11-10 00:00:00
abstract：:Fourteen (hetero-)(arylidene)arylhydrazide derivatives (ABH1-ABH14) were synthesized, and their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE) were evaluated. Compound ABH5 most potently inhibited MAO-B with an IC50 value of 0.025 ± 0.0019 μM; ABH2 and ABH3 exhibited high IC50 ...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.0c00136
更新日期：2020-11-09 00:00:00
abstract：:For a future structure-activity relationship (SAR) study, a library of desketoraloxifene analogues has been prepared by parallel synthesis using iodocyclization and subsequent palladium-catalyzed coupling reactions. Points of desketoraloxifene diversification involve the two phenolic hydroxyl groups and the aliphatic ...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/co200090p
更新日期：2011-09-12 00:00:00
abstract：:Acetylenic tertiary alcohols are well-known to be compounds that are biologically more stable than their corresponding secondary alcohols. The linkage of an acetylenic compound to a polymer support and further introduction of molecular diversity was found to be an interesting way to generate libraries of hydroxy acety...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/co300034y
更新日期：2012-06-11 00:00:00
abstract：:A condition-based skeletal divergent synthesis was explored to achieve skeletal diversity in two component condensation reaction. Cyanomethyl benzimidazole was reacted with α-bromoketone under thermal conditions to furnish 2-aminofuranyl-benzimidazoles, while the same reaction afforded 3-cyano-benzopyrrolo-imidazoles ...
journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.7b00052
更新日期：2017-07-10 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.7b00184
更新日期：2018-03-12 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2011-07-11 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/co3000488
更新日期：2012-10-08 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.0c00159
更新日期：2020-12-14 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.6b00162
更新日期：2017-02-13 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.6b00040
更新日期：2016-10-10 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/acscombsci.6b00010
更新日期：2016-05-09 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/co3001154
更新日期：2013-01-14 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/co1000103
更新日期：2011-01-10 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2011-01-10 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
pub_type： 信件
doi：10.1021/co200165j
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2015-09-14 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/co500085t
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abstract：:DNA-encoded synthesis is rekindling interest in combinatorial compound libraries for drug discovery and in technology for automated and quantitative library screening. Here, we disclose a microfluidic circuit that enables functional screens of DNA-encoded compound beads. The device carries out library bead distributio...
journal_title：ACS combinatorial science
pub_type： 杂志文章
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2020-03-09 00:00:00
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/co2000357
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journal_title：ACS combinatorial science
pub_type： 杂志文章
doi：10.1021/co300123y
更新日期：2012-12-10 00:00:00
