Facile Synthesis of Azaarene-Substituted Hydroxycoumarins Possessing High Biological Activities via Three-Component C(sp(3))-H Functionalization.

Abstract:

:An unprecedented three-component C(sp(3))-H functionalization of 2-alkylazaarenes with aryl aldehydes and 4-hydroxycoumarins was realized, providing azaarene-substituted 3-benzyl-4-hydroxycoumarins in good to excellent yields. These new target compounds displayed broad-spectrum antibacterial activities, providing a new type of antibacterial skeleton.

journal_name

ACS Comb Sci

authors

Dong H,Xu L,Li SS,Wang L,Shao CL,Xiao J

doi

10.1021/acscombsci.6b00082

subject

Has Abstract

pub_date

2016-09-12 00:00:00

pages

604-10

issue

9

eissn

2156-8952

issn

2156-8944

journal_volume

18

pub_type

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