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Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods.

Abstract：

:A combination of flow and batch chemistries has been successfully applied to the assembly of a series of trisubstituted drug-like pyrrolidines. This study demonstrates the efficient preparation of a focused library of these pharmaceutically important structures using microreactor technologies, as well as classical parallel synthesis techniques, and thus exemplifies the impact of integrating innovative enabling tools within the drug discovery process.

journal_name

ACS Comb Sci

journal_title

ACS combinatorial science

authors

Baumann M,Baxendale IR,Kuratli C,Ley SV,Martin RE,Schneider J

doi

10.1021/co2000357

subject

Has Abstract

pub_date

2011-07-11 00:00:00

pages

405-13

issue

4

eissn

2156-8952

issn

2156-8944

journal_volume

13

pub_type

杂志文章

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